Aminokiselinska sekvenca
uredi
Dužina polipeptidnog lanca je 580 aminokiselina , а molekulska težina 64.889 Da .[ 8]
10 20 30 40 50 MGEKAVPLLR RRRVKRSCPS CGSELGVEEK RGKGNPISIQ LFPPELVEHI ISFLPVRDLV ALGQTCRYFH EVCDGEGVWR RICRRLSPRL QDQGSGVRPW KRAAILNYTK GLYFQAFGGR RRCLSKSVAP LLAHGYRRFL PTKDHVFILD YVGTLFFLKN ALVSTLGQMQ WKRACRYVVL CRGAKDFASD PRCDTVYRKY LYVLATREPQ EVVGTTSSRA CDCVEVYLQS SGQRVFKMTF HHSMTFKQIV LVGQETQRAL LLLTEEGKIY SLVVNETQLD QPRSYTVQLA LRKVSHYLPH LRVACMTSNQ SSTLYVTDQG GVYFEVHTPG VYRDLFGTLQ AFDPLDQQMP LALSLPAKIL FCALGYNHLG LVDEFGRIFM QGNNRYGQLG TGDKMDRGEP TQVCYLQRPI TLWCGLNHSL VLSQSSEFSK ELLGCGCGAG GRLPGWPKGS ASFVKLQVKV PLCACALCAT RECLYILSSH DIEQHAPYRH LPASRVVGTP EPSLGARAPQ DPGGMAQACE EYLSQIHSCQ TLQDRTEKMK EIVGWMPLMA AQKDFFWEAL DMLQRAEGGG GGVGPPAPET
Ovaj gen kodira člana porodice proteina F-kutije koju karakterizira približno 40-aminokiselinski motiv, F-kutija. Proteini F-kutije čine jednu od četiri podjedinice kompleksa proteinskih ubikvitin -ligaza zvanih SCF (SKP1-culin-F-kutija), koji funkcioniraju u ubikvitinaciji ovisnoj o fosforilaciji . Proteini F-kutije podijeljeni su u tri klase: Fbws koji sadrže domene WD-40, Fbls koji sadrže leucin -bogate ponavljanja i Fbxs koji sadrže ili različite module interakcija protein-protein ili bez prepoznatljivih motiva. Protein kodiran ovim genom pripada klasi Fbx. Alternativna prerada ovog gena generira dvije varijante transkripta .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000106336 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000089984 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins" . Curr Biol . 9 (20): 1177–9. doi :10.1016/S0960-9822(00)80020-2 PMID 10531035 . S2CID 7467493 . ^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins" . Curr Biol . 9 (20): 1180–2. doi :10.1016/S0960-9822(00)80021-4 PMID 10531037 . S2CID 14341845 . ^ a b "Entrez Gene: FBXO24 F-box protein 24" .^ "UniProt, O75426" (jezik: англ.). Pristupljeno 25. 9. 2021 .CS1 održavanje: nepoznati jezik (link )
Dopunska literatura
uredi
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7" . Nature . 424 (6945): 157–64. Bibcode :2003Natur.424..157H . doi :10.1038/nature01782 PMID 12853948 . Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology" . Science . 300 (5620): 767–72. Bibcode :2003Sci...300..767S . doi :10.1126/science.1083423 . PMC 2882961 PMID 12690205 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence" . Genome Res . 8 (11): 1097–108. doi :10.1101/gr.8.11.1097 PMID 9847074 . 
