EXTL3

EXTL3
Identifikatori
Aliasi	EXTL3
Vanjski ID-jevi	OMIM: 605744 MGI: 1860765 HomoloGene: 1103 GeneCards: EXTL3
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	28,756,561 bp
Lokacija gena (miš)
Hrom.	Hromosom 14 (miš)
Kraj	65,387,304 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; • vezivanje iona metala; • glycosyltransferase activity;
Ćelijska komponenta	• integral component of membrane; • membrana; • Endoplazmatski retikulum; • endoplasmic reticulum membrane; • Golđijev aparat;
Biološki proces	• positive regulation of cell growth; • IRE1-mediated unfolded protein response; • heparan sulfate proteoglycan biosynthetic process; • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation;
	Izvori:Amigo / QuickGO
Ortolozi
	2137
	54616
	ENSG00000012232
	ENSMUSG00000021978
	O43909
	Q9WVL6; Q6P1H4
	NM_001440
	NM_018788; NM_001360385
	NP_001431
NP_061258; NP_001347314; NP_001391867; NP_001391868; NP_001391869;
	NP_001391870; NP_001391871; NP_001391872; NP_001391873; NP_001391874; NP_001391875
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Egzostozinoliki protein 3 je protein koji je kod ljudi kodiran genom EXTL3.^[5]^[6]^[7]^[8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 919 aminokiselina, а molekulska težina 104.749 Da.^[9]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MTGYTMLRNG	GAGNGGQTCM	LRWSNRIRLT	WLSFTLFVIL	VFFPLIAHYY
LTTLDEADEA	GKRIFGPRVG	NELCEVKHVL	DLCRIRESVS	EELLQLEAKR
QELNSEIAKL	NLKIEACKKS	IENAKQDLLQ	LKNVISQTEH	SYKELMAQNQ
PKLSLPIRLL	PEKDDAGLPP	PKATRGCRLH	NCFDYSRCPL	TSGFPVYVYD
SDQFVFGSYL	DPLVKQAFQA	TARANVYVTE	NADIACLYVI	LVGEMQEPVV
LRPAELEKQL	YSLPHWRTDG	HNHVIINLSR	KSDTQNLLYN	VSTGRAMVAQ
STFYTVQYRP	GFDLVVSPLV	HAMSEPNFME	IPPQVPVKRK	YLFTFQGEKI
ESLRSSLQEA	RSFEEEMEGD	PPADYDDRII	ATLKAVQDSK	LDQVLVEFTC
KNQPKPSLPT	EWALCGERED	RLELLKLSTF	ALIITPGDPR	LVISSGCATR
LFEALEVGAV	PVVLGEQVQL	PYQDMLQWNE	AALVVPKPRV	TEVHFLLRSL
SDSDLLAMRR	QGRFLWETYF	STADSIFNTV	LAMIRTRIQI	PAAPIREEAA
AEIPHRSGKA	AGTDPNMADN	GDLDLGPVET	EPPYASPRYL	RNFTLTVTDF
YRSWNCAPGP	FHLFPHTPFD	PVLPSEAKFL	GSGTGFRPIG	GGAGGSGKEF
QAALGGNVPR	EQFTVVMLTY	EREEVLMNSL	ERLNGLPYLN	KVVVVWNSPK
LPSEDLLWPD	IGVPIMVVRT	EKNSLNNRFL	PWNEIETEAI	LSIDDDAHLR
HDEIMFGFRV	WREARDRIVG	FPGRYHAWDI	PHQSWLYNSN	YSCELSMVLT
GAAFFHKYYA	YLYSYVMPQA	IRDMVDEYIN	CEDIAMNFLV	SHITRKPPIK
VTSRWTFRCP	GCPQALSHDD	SHFHERHKCI	NFFVKVYGYM	PLLYTQFRVD
SVLFKTRLPH	DKTKCFKFI

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000012232 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021978 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Van Hul W, Wuyts W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Bossuyt P, Willems PJ (Apr 1998). "Identification of a third EXT-like gene (EXTL3) belonging to the EXT gene family". Genomics. 47 (2): 230–7. doi:10.1006/geno.1997.5101. PMID 9479495.
^ Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ (Mar 1998). "Identification and characterization of a novel member of the EXT gene family, EXTL2". Eur J Hum Genet. 5 (6): 382–9. doi:10.1159/000484796. PMID 9450183.
^ Mizuno K, Irie S, Sato TA (Mar 2001). "Overexpression of EXTL3/EXTR1 enhances NF-kappaB activity induced by TNF-alpha". Cell Signal. 13 (2): 125–30. doi:10.1016/S0898-6568(00)00144-3. PMID 11257457.
^ "Entrez Gene: EXTL3 exostoses (multiple)-like 3".
^ "UniProt, O43909" (jezik: engleski). Pristupljeno 17. 9. 2021.

Dopunska literatura

Saito T, Seki N, Yamauchi M, et al. (1998). "Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family". Biochem. Biophys. Res. Commun. 243 (1): 61–6. doi:10.1006/bbrc.1997.8062. PMID 9473480.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
McCormick C, Duncan G, Goutsos KT, Tufaro F (2000). "The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 668–73. doi:10.1073/pnas.97.2.668. PMC 15388. PMID 10639137.
Kobayashi S, Akiyama T, Nata K, et al. (2000). "Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor". J. Biol. Chem. 275 (15): 10723–6. doi:10.1074/jbc.275.15.10723. PMID 10753861.
Kim BT, Kitagawa H, Tamura Ji J, et al. (2002). "Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation". J. Biol. Chem. 277 (16): 13659–65. doi:10.1074/jbc.M111630200. PMID 11832488.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bishnupuri KS, Luo Q, Korzenik JR, et al. (2007). "Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes". Cancer Biol. Ther. 5 (12): 1714–20. doi:10.4161/cbt.5.12.3469. PMID 17106246.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000012232 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021978 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9479495-5] Van Hul W, Wuyts W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Bossuyt P, Willems PJ (Apr 1998). "Identification of a third EXT-like gene (EXTL3) belonging to the EXT gene family". Genomics. 47 (2): 230–7. doi:10.1006/geno.1997.5101. PMID 9479495.

[pmid9450183-6] Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ (Mar 1998). "Identification and characterization of a novel member of the EXT gene family, EXTL2". Eur J Hum Genet. 5 (6): 382–9. doi:10.1159/000484796. PMID 9450183.

[pmid11257457-7] Mizuno K, Irie S, Sato TA (Mar 2001). "Overexpression of EXTL3/EXTR1 enhances NF-kappaB activity induced by TNF-alpha". Cell Signal. 13 (2): 125–30. doi:10.1016/S0898-6568(00)00144-3. PMID 11257457.

[entrez-8] "Entrez Gene: EXTL3 exostoses (multiple)-like 3".

[UniProt-9] "UniProt, O43909" (jezik: engleski). Pristupljeno 17. 9. 2021.

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