EPC2
Pojačavač polikomb homologa 2 (Drosophila) jest protein koji je kod ljudi kodiran genom EPC2 sa hromosoma 2.[5]
Amiokiselininska sekvenca uredi
Dužina polipeptidnog lanca je 807 aminokiselina, a molekulska težina 91.095 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSKLSFRARA | LDAAKPLPIY | RGKDMPDLND | CVSINRAVPQ | MPTGMEKEEE | ||||
| SEHHLQRAIS | AQQVFREKKE | SMVIPVPEAE | SNVNYYNRLY | KGEFKQPKQF | ||||
| IHIQPFNLDN | EQPDYDMDSE | DETLLNRLNR | KMEIKPLQFE | IMIDRLEKAS | ||||
| SNQLVTLQEA | KLLLNEDDYL | IKAVYDYWVR | KRKNCRGPSL | IPQIKQEKRD | ||||
| GSTNNDPYVA | FRRRTEKMQT | RKNRKNDEAS | YEKMLKLRRE | FSRAITILEM | ||||
| IKRREKTKRE | LLHLTLEVVE | KRYHLGDYGG | EILNEVKISR | SEKELYATPA | ||||
| TLHNGNHHKV | QECKTKHPHH | LSLKEEASDV | VRQKKKYPKK | PKAEALITSQ | ||||
| QPTPETLPVI | NKSDIKQYDF | HSSDEDEFPQ | VLSPVSEPEE | ENDPDGPCAF | ||||
| RRRAGCQYYA | PRLDQANHSC | ENSELADLDK | LRYRHCLTTL | TVPRRCIGFA | ||||
| RRRIGRGGRV | IMDRISTEHD | PVLKQIDPEM | LNSFSSSSQT | IDFSSNFSRT | ||||
| NASSKHCENR | LSLSEILSNI | RSCRLQCFQP | RLLNLQDSDS | EECTSRKPGQ | ||||
| TVNNKRVSAA | SVALLNTSKN | GISVTGGITE | EQFQTHQQQL | VQMQRQQLAQ | ||||
| LQQKQQSQHS | SQQTHPKAQG | SSTSDCMSKT | LDSASAHFAA | SAVVSAPVPS | ||||
| RSEVAKEQNT | GHNNINGVVQ | PSGTSKTLYS | TNMALSSSPG | ISAVQLVRTV | ||||
| GHTTTNHLIP | ALCTSSPQTL | PMNNSCLTNA | VHLNNVSVVS | PVNVHINTRT | ||||
| SAPSPTALKL | ATVAASMDRV | PKVTPSSAIS | SIARENHEPE | RLGLNGIAET | ||||
| TVAMEVT |
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000135999 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069495 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Enhancer of polycomb homolog 2 (Drosophila)".
- ^ "UniProt, Q52LR7" (jezik: engleski). Pristupljeno 17. 11. 2021.
Dopunska literatura uredi
- Doyon Y, Cayrou C, Ullah M, Landry AJ, Côté V, Selleck W, Lane WS, Tan S, Yang XJ, Côté J (januar 2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Molecular Cell. 21 (1): 51–64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.
- Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, Cantor AB, Orkin SH (oktobar 2010). "A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs". Cell. 143 (2): 313–24. doi:10.1016/j.cell.2010.09.010. PMC 3018841. PMID 20946988.
- Kim S, Swaminathan S, Shen L, Risacher SL, Nho K, Foroud T, Shaw LM, Trojanowski JQ, Potkin SG, Huentelman MJ, Craig DW, DeChairo BM, Aisen PS, Petersen RC, Weiner MW, Saykin AJ (januar 2011). "Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort". Neurology. 76 (1): 69–79. doi:10.1212/WNL.0b013e318204a397. PMC 3030225. PMID 21123754.
- Doyon Y, Selleck W, Lane WS, Tan S, Côté J (mart 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Molecular and Cellular Biology. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
- Hayakawa T, Zhang F, Hayakawa N, Ohtani Y, Shinmyozu K, Nakayama J, Andreassen PR (april 2010). "MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks". Journal of Cell Science. 123 (Pt 7): 1124–30. doi:10.1242/jcs.060178. PMC 2844321. PMID 20332121.
- Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, Rafferty I, et al. (maj 2008). "A genome-wide association study identifies protein quantitative trait loci (pQTLs)". PLOS Genetics. 4 (5): e1000072. doi:10.1371/journal.pgen.1000072. PMC 2362067. PMID 18464913.
- Hayakawa T, Ohtani Y, Hayakawa N, Shinmyozu K, Saito M, Ishikawa F, Nakayama J (juni 2007). "RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation". Genes to Cells. 12 (6): 811–26. doi:10.1111/j.1365-2443.2007.01089.x. PMID 17573780. S2CID 10003129.
- Guil S, Soler M, Portela A, Carrère J, Fonalleras E, Gómez A, Villanueva A, Esteller M (juni 2012). "Intronic RNAs mediate EZH2 regulation of epigenetic targets". Nature Structural & Molecular Biology. 19 (7): 664–70. doi:10.1038/nsmb.2315. PMID 22659877. S2CID 14906359.
- Huang X, Spencer GJ, Lynch JT, Ciceri F, Somerville TD, Somervaille TC (maj 2014). "Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells". Leukemia. 28 (5): 1081–91. doi:10.1038/leu.2013.316. PMC 3998875. PMID 24166297.
