EPC2

Pojačavač polikomb homologa 2 (Drosophila) jest protein koji je kod ljudi kodiran genom EPC2 sa hromosoma 2.

EPC2
Identifikatori
Aliasi	EPC2
Vanjski ID-jevi	OMIM: 611000 MGI: 1278321 HomoloGene: 32274 GeneCards: EPC2
Lokacija gena (čovjek) Hrom. Hromosom 2 (čovjek) Bend 2q23.1 Početak 148,644,440 bp Kraj 148,787,569 bp
Lokacija gena (miš) Hrom. Hromosom 2 (miš) Bend 2 C1.1|2 28.62 cM Početak 49,341,498 bp Kraj 49,441,960 bp
Ontologija gena Molekularna funkcija • histone acetyltransferase activity Ćelijska komponenta • jedro • NuA4 histone acetyltransferase complex • Piccolo NuA4 histone acetyltransferase complex Biološki proces • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • cellular response to DNA damage stimulus • GO:0100026 Popravka DNK • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • histone acetylation • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	26122	227867
Ensembl	ENSG00000135999	ENSMUSG00000069495
UniProt	Q52LR7	Q8C0I4
RefSeq (mRNK)	NM_015630	NM_172663
RefSeq (bjelančevina)	NP_056445	NP_766251
Lokacija (UCSC)	Chr 2: 148.64 – 148.79 Mb	Chr 2: 49.34 – 49.44 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 807 aminokiselina, a molekulska težina 91.095 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSKLSFRARA		LDAAKPLPIY		RGKDMPDLND		CVSINRAVPQ		MPTGMEKEEE
SEHHLQRAIS		AQQVFREKKE		SMVIPVPEAE		SNVNYYNRLY		KGEFKQPKQF
IHIQPFNLDN		EQPDYDMDSE		DETLLNRLNR		KMEIKPLQFE		IMIDRLEKAS
SNQLVTLQEA		KLLLNEDDYL		IKAVYDYWVR		KRKNCRGPSL		IPQIKQEKRD
GSTNNDPYVA		FRRRTEKMQT		RKNRKNDEAS		YEKMLKLRRE		FSRAITILEM
IKRREKTKRE		LLHLTLEVVE		KRYHLGDYGG		EILNEVKISR		SEKELYATPA
TLHNGNHHKV		QECKTKHPHH		LSLKEEASDV		VRQKKKYPKK		PKAEALITSQ
QPTPETLPVI		NKSDIKQYDF		HSSDEDEFPQ		VLSPVSEPEE		ENDPDGPCAF
RRRAGCQYYA		PRLDQANHSC		ENSELADLDK		LRYRHCLTTL		TVPRRCIGFA
RRRIGRGGRV		IMDRISTEHD		PVLKQIDPEM		LNSFSSSSQT		IDFSSNFSRT
NASSKHCENR		LSLSEILSNI		RSCRLQCFQP		RLLNLQDSDS		EECTSRKPGQ
TVNNKRVSAA		SVALLNTSKN		GISVTGGITE		EQFQTHQQQL		VQMQRQQLAQ
LQQKQQSQHS		SQQTHPKAQG		SSTSDCMSKT		LDSASAHFAA		SAVVSAPVPS
RSEVAKEQNT		GHNNINGVVQ		PSGTSKTLYS		TNMALSSSPG		ISAVQLVRTV
GHTTTNHLIP		ALCTSSPQTL		PMNNSCLTNA		VHLNNVSVVS		PVNVHINTRT
SAPSPTALKL		ATVAASMDRV		PKVTPSSAIS		SIARENHEPE		RLGLNGIAET
TVAMEVT

Dopunska literatura

• Doyon Y, Cayrou C, Ullah M, Landry AJ, Côté V, Selleck W, Lane WS, Tan S, Yang XJ, Côté J (januar 2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Molecular Cell. 21 (1): 51–64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.
• Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, Cantor AB, Orkin SH (oktobar 2010). "A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs". Cell. 143 (2): 313–24. doi:10.1016/j.cell.2010.09.010. PMC 3018841. PMID 20946988.
• Kim S, Swaminathan S, Shen L, Risacher SL, Nho K, Foroud T, Shaw LM, Trojanowski JQ, Potkin SG, Huentelman MJ, Craig DW, DeChairo BM, Aisen PS, Petersen RC, Weiner MW, Saykin AJ (januar 2011). "Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort". Neurology. 76 (1): 69–79. doi:10.1212/WNL.0b013e318204a397. PMC 3030225. PMID 21123754.
• Doyon Y, Selleck W, Lane WS, Tan S, Côté J (mart 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Molecular and Cellular Biology. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
• Hayakawa T, Zhang F, Hayakawa N, Ohtani Y, Shinmyozu K, Nakayama J, Andreassen PR (april 2010). "MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks". Journal of Cell Science. 123 (Pt 7): 1124–30. doi:10.1242/jcs.060178. PMC 2844321. PMID 20332121.
• Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, Rafferty I, et al. (maj 2008). "A genome-wide association study identifies protein quantitative trait loci (pQTLs)". PLOS Genetics. 4 (5): e1000072. doi:10.1371/journal.pgen.1000072. PMC 2362067. PMID 18464913.
• Hayakawa T, Ohtani Y, Hayakawa N, Shinmyozu K, Saito M, Ishikawa F, Nakayama J (juni 2007). "RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation". Genes to Cells. 12 (6): 811–26. doi:10.1111/j.1365-2443.2007.01089.x. PMID 17573780. S2CID 10003129.
• Guil S, Soler M, Portela A, Carrère J, Fonalleras E, Gómez A, Villanueva A, Esteller M (juni 2012). "Intronic RNAs mediate EZH2 regulation of epigenetic targets". Nature Structural & Molecular Biology. 19 (7): 664–70. doi:10.1038/nsmb.2315. PMID 22659877. S2CID 14906359.
• Huang X, Spencer GJ, Lynch JT, Ciceri F, Somerville TD, Somervaille TC (maj 2014). "Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells". Leukemia. 28 (5): 1081–91. doi:10.1038/leu.2013.316. PMC 3998875. PMID 24166297.