EPC1

Pojačivač polikombnog homologa 1 je protein koji je kod ljudig kodoran genom EPC1.

EPC1
Identifikatori
Aliasi	EPC1
Vanjski ID-jevi	OMIM: 610999 MGI: 1278322 HomoloGene: 32627 GeneCards: EPC1
Lokacija gena (čovjek) Hrom. Hromosom 10 (čovjek) Bend 10p11.22 Početak 32,267,751 bp Kraj 32,378,798 bp
Lokacija gena (miš) Hrom. Hromosom 18 (miš) Bend 18|18 A1 Početak 6,435,951 bp Kraj 6,516,108 bp
Ontologija gena Molekularna funkcija • histone acetyltransferase activity • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • Piccolo NuA4 histone acetyltransferase complex • Jedarna membrana • jedro • NuA4 histone acetyltransferase complex • nukleoplazma Biološki proces • vascular associated smooth muscle cell differentiation • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • histone H4 acetylation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • histone H2A acetylation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of growth • negative regulation of gene expression, epigenetic • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of G0 to G1 transition • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	80314	13831
Ensembl	ENSG00000120616	ENSMUSG00000024240
UniProt	Q9H2F5	Q8C9X6
RefSeq (mRNK)	NM_001272004 NM_001272019 NM_001282391 NM_025209	NM_001276350 NM_007935 NM_027497
RefSeq (bjelančevina)	NP_001258933 NP_001258948 NP_001269320 NP_079485	NP_001263279 NP_031961 NP_081773
Lokacija (UCSC)	Chr 10: 32.27 – 32.38 Mb	Chr 18: 6.44 – 6.52 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 836 aminokiselina, а molekulska težina 93.463.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSKLSFRARA		LDASKPLPVF		RCEDLPDLHE		YASINRAVPQ		MPTGMEKEEE
SEHHLQRAIS		AQQVYGEKRD		NMVIPVPEAE		SNIAYYESIY		PGEFKMPKQL
IHIQPFSLDA		EQPDYDLDSE		DEVFVNKLKK		KMDICPLQFE		EMIDRLEKGS
GQQPVSLQEA		KLLLKEDDEL		IREVYEYWIK		KRKNCRGPSL		IPSVKQEKRD
GSSTNDPYVA		FRRRTEKMQT		RKNRKNDEAS		YEKMLKLRRD		LSRAVTILEM
IKRREKSKRE		LLHLTLEIME		KRYNLGDYNG		EIMSEVMAQR		QPMKPTYAIP
IIPITNSSQF		KHQEAMDVKE		FKVNKQDKAD		LIRPKRKYEK		KPKVLPSSAA
ATPQQTSPAA		LPVFNAKDLN		QYDFPSSDEE		PLSQVLSGSS		EAEEDNDPDG
PFAFRRKAGC		QYYAPHLDQT		GNWPWTSPKD		GGLGDVRYRY		CLTTLTVPQR
CIGFARRRVG		RGGRVLLDRA		HSDYDSVFHH		LDLEMLSSPQ		HSPVNQFANT
SETNTSDKSF		SKDLSQILVN		IKSCRWRHFR		PRTPSLHDSD		NDELSCRKLY
RSINRTGTAQ		PGTQTCSTST		QSKSSSGSAH		FAFTAEQYQQ		HQQQLALMQK
QQLAQIQQQQ		ANSNSSTNTS		QNLASNQQKS		GFRLNIQGLE		RTLQGFVSKT
LDSASAQFAA		SALVTSEQLM		GFKMKDDVVL		GIGVNGVLPA		SGVYKGLHLS
STTPTALVHT		SPSTAGSALL		QPSNITQTSS		SHSALSHQVT		AANSATTQVL
IGNNIRLTVP		SSVATVNSIA		PINARHIPRT		LSAVPSSALK		LAAAANCQVS
KVPSSSSVDS		VPRENHESEK		PALNNIADNT		VAMEVT

Dopunska literatura

• Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
• Liedtke W, Meyer G, Faustmann PM, et al. (1997). "Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of the V delta 2J delta 3 lineage in multiple sclerosis patients". Int. Immunol. 9 (7): 1031–41. doi:10.1093/intimm/9.7.1031. PMID 9237112.
• Wang X, Stollar BD (1999). "Immunoglobulin VH gene expression in human aging". Clin. Immunol. 93 (2): 132–42. doi:10.1006/clim.1999.4781. PMID 10527689.
• Kenny TP, Semrad TJ, Malyj W, Robbins DL (2001). "Mutational analysis of immunoglobulin germline derived Vlambda4B light chains in rheumatoid arthritis". Clin. Immunol. 99 (2): 283–90. doi:10.1006/clim.2001.5020. PMID 11318600.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans". Mol. Cell. Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Attwooll C, Oddi S, Cartwright P, et al. (2005). "A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner". J. Biol. Chem. 280 (2): 1199–208. doi:10.1074/jbc.M412509200. PMID 15536069.
• Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Kee HJ, Kim JR, Nam KI, et al. (2007). "Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation". J. Biol. Chem. 282 (10): 7700–9. doi:10.1074/jbc.M611198200. PMID 17192267.