EPB41L5

EPB41L5
Identifikatori
Aliasi	EPB41L5
Vanjski ID-jevi	OMIM: 611730 MGI: 103006 HomoloGene: 32492 GeneCards: EPB41L5
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	120,179,119 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	119,576,730 bp
Ontologija gena
Molekularna funkcija	• protein domain specific binding; • cytoskeletal protein binding; • structural constituent of cytoskeleton;
Ćelijska komponenta	• focal adhesion; • adherens junction; • ćelijska membrana; • ruffle membrane; • međućelijske veze; • cell leading edge; • citoplazma; • citoskelet; • jedro; • citosol;
Biološki proces	• cellular response to transforming growth factor beta stimulus; • somitogenesis; • axial mesoderm development; • endoderm development; • negative regulation of cell-cell adhesion; • embryonic foregut morphogenesis; • epithelial cell morphogenesis; • positive regulation of cell-matrix adhesion; • substrate-dependent cell migration, cell attachment to substrate; • neural plate morphogenesis; • somite rostral/caudal axis specification; • ectoderm development; • positive regulation of epithelial cell migration; • in utero embryonic development; • negative regulation of protein binding; • positive regulation of epithelial to mesenchymal transition; • regulation of establishment of protein localization; • axial mesoderm morphogenesis; • epithelial to mesenchymal transition; • posttranscriptional regulation of gene expression; • unidimensional cell growth; • positive regulation of focal adhesion assembly; • mesoderm migration involved in gastrulation; • positive regulation of protein binding; • cell morphogenesis involved in differentiation; • mesoderm development; • apical constriction; • left/right axis specification; • actin cytoskeleton organization; • paraxial mesoderm development; • actomyosin structure organization;
	Izvori:Amigo / QuickGO
Ortolozi
	57669
	226352
	ENSG00000115109
	ENSMUSG00000026383
	Q9HCM4
	Q8BGS1
NM_001184937; NM_001184938; NM_001184939; NM_020909; NM_001330307;
	NM_001330310
	NM_001113416; NM_145506
NP_001171866; NP_001171867; NP_001171868; NP_001317236; NP_001317239;
	NP_065960
	NP_001106887; NP_663481
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Bend 4-liki protein 5 eritrocitne membrane jest protein koji je kod ljudi kodiran genom EPB41L5 sa hromosoma 2.^[5]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 733 aminokiseline, a molekulska težina 81.856 Da.^[6].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MLSFFRRTLG	RRSMRKHAEK	ERLREAQRAA	THIPAAGDSK	SIITCRVSLL
DGTDVSVDLP	KKAKGQELFD	QIMYHLDLIE	SDYFGLRFMD	SAQVAHWLDG
TKSIKKQVKI	GSPYCLHLRV	KFYSSEPNNL	REELTRYLFV	LQLKQDILSG
KLDCPFDTAV	QLAAYNLQAE	LGDYDLAEHS	PELVSEFRFV	PIQTEEMELA
IFEKWKEYRG	QTPAQAETNY	LNKAKWLEMY	GVDMHVVKAR	DGNDYSLGLT
PTGVLVFEGD	TKIGLFFWPK	ITRLDFKKNK	LTLVVVEDDD	QGKEQEHTFV
FRLDHPKACK	HLWKCAVEHH	AFFRLRGPVQ	KSSHRSGFIR	LGSRFRYSGK
TEYQTTKTNK	ARRSTSFERR	PSKRYSRRTL	QMKACATKPE	ELSVHNNVST
QSNGSQQAWG	MRSALPVSPS	ISSAPVPVEI	ENLPQSPGTD	QHDRKCIPLN
IDLLNSPDLL	EATIGDVIGA	SDTMETSQAL	NDVNVATRLP	GLGEPEVEYE
TLKDTSEKLK	QLEMENSPLL	SPRSNIDVNI	NSQEEVVKLT	EKCLNNVIES
PGLNVMRVPP	DFKSNILKAQ	VEAVHKVTKE	DSLLSHKNAN	VQDAATNSAV
LNENNVPLPK	ESLETLMLIT	PADSGSVLKE	ATDELDALLA	SLTENLIDHT
VAPQVSSTSM	ITPRWIVPQS	GAMSNGLAGC	EMLLTGKEGH	GNKDGISLIS
PPAPFLVDAV	TSSGPILAEE	AVLKQKCLLT	TEL

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115109 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026383 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Erythrocyte membrane protein band 4.1 like 5". Pristupljeno 26. 4. 2012.
^ "UniProt, Q9HCM4" (jezik: engleski). Pristupljeno 17. 11. 2021.

Dopunska literatura

Gosens I, Sessa A, den Hollander AI, Letteboer SJ, Belloni V, Arends ML, Le Bivic A, Cremers FP, Broccoli V, Roepman R (Nov 2007). "FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5 polarity complex". Experimental Cell Research. 313 (19): 3959–70. doi:10.1016/j.yexcr.2007.08.025. PMID 17920587.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115109 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026383 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Erythrocyte membrane protein band 4.1 like 5". Pristupljeno 26. 4. 2012.

[UniProt-6] "UniProt, Q9HCM4" (jezik: engleski). Pristupljeno 17. 11. 2021.

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