E74-liki faktor 1 (transkripcijski faktor ETS-domena) je protein koji je kod ljudi kodiran genom ELF1.[5]

ELF1
Identifikatori
AliasiELF1
Vanjski ID-jeviOMIM: 189973 MGI: 107180 HomoloGene: 7303 GeneCards: ELF1
Lokacija gena (čovjek)
Hromosom 13 (čovjek)
Hrom.Hromosom 13 (čovjek)[1]
Hromosom 13 (čovjek)
Genomska lokacija za ELF1
Genomska lokacija za ELF1
Bend13q14.11Početak40,931,924 bp[1]
Kraj41,061,440 bp[1]
Lokacija gena (miš)
Hromosom 14 (miš)
Hrom.Hromosom 14 (miš)[2]
Hromosom 14 (miš)
Genomska lokacija za ELF1
Genomska lokacija za ELF1
Bend14|14 D3Početak79,718,634 bp[2]
Kraj79,819,934 bp[2]
Ontologija gena
Molekularna funkcija GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA binding
sequence-specific DNA binding
GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001948, GO:0016582 protein binding
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta Jedro
Nukleoplazma
Biološki proces GO:0032657 regulation of cytokine production
GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
Ćelijska diferencijacija
GO:0009373 regulation of transcription, DNA-templated
transcription, DNA-templated
GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
negative regulation of T cell receptor signaling pathway
transcription by RNA polymerase II
regulation of cytokine-mediated signaling pathway
regulation of B cell receptor signaling pathway
GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001145353
NM_172373
NM_001370329
NM_001370330
NM_001370331

NM_001370332

NM_001286411
NM_001286412
NM_007920

RefSeq (bjelančevina)
NP_001138825
NP_758961
NP_001357258
NP_001357259
NP_001357260

NP_001357261

NP_001273340
NP_001273341
NP_031946

Lokacija (UCSC)Chr 13: 40.93 – 41.06 MbChr 14: 79.72 – 79.82 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 619 aminokiselina, a molekulska težina 67.498 Da.[6]

1020304050
MAAVVQQNDLVFEFASNVMEDERQLGDPAIFPAVIVEHVPGADILNSYAG
LACVEEPNDMITESSLDVAEEEIIDDDDDDITLTVEASCHDGDETIETIE
AAEALLNMDSPGPMLDEKRINNNIFSSPEDDMVVAPVTHVSVTLDGIPEV
METQQVQEKYADSPGASSPEQPKRKKGRKTKPPRPDSPATTPNISVKKKN
KDGKGNTIYLWEFLLALLQDKATCPKYIKWTQREKGIFKLVDSKAVSRLW
GKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLIYIN
DEDPSSSIESSDPSLSSSATSNRNQTSRSRVSSSPGVKGGATTVLKPGNS
KAAKPKDPVEVAQPSEVLRTVQPTQSPYPTQLFRTVHVVQPVQAVPEGEA
ARTSTMQDETLNSSVQSIRTIQAPTQVPVVVSPRNQQLHTVTLQTVPLTT
VIASTDPSAGTGSQKFILQAIPSSQPMTVLKENVMLQSQKAGSPPSIVLG
PAQVQQVLTSNVQTICNGTVSVASSPSFSATAPVVTFSPRSSQLVAHPPG
TVITSVIKTQETKTLTQEVEKKESEDHLKENTEKTEQQPQPYVMVVSSSN
GFTSQVAMKQNELLEPNSF
Simboli

Funkcija uredi

Ovaj gen kodira faktor transkripcije specifičan za transformaciju E26. Kodirani protein primarno se eksprimira u limfoidnim ćelijamama i može djelovati i kao pojačivač i kao potiskivač za regulaciju transkripcije različitih gena. Alternativno prerađivanje rezultira u više varijanti transkripta.[5]

Reference uredi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120690 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036461 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: E74-like factor 1 (ets domain transcription factor)".
  6. ^ "UniProt, P32519". Pristupljeno 11. 9. 2017.

Dopunaka literatura uredi