ELAC1

ELAC1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3ZWF
Identifikatori
Aliasi	ELAC1
Vanjski ID-jevi	OMIM: 608079 MGI: 1890495 HomoloGene: 10272 GeneCards: ELAC1
Lokacija gena (čovjek)
Hrom.	Hromosom 18 (čovjek)
Kraj	50,988,121 bp
Lokacija gena (miš)
Hrom.	Hromosom 18 (miš)
Kraj	73,887,550 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nuclease activity; • endonuclease activity; • 3'-tRNA processing endoribonuclease activity; • hydrolase activity; • vezivanje iona metala; • endoribonuclease activity, producing 5'-phosphomonoesters;
Ćelijska komponenta	• citoplazma; • citosol; • jedro;
Biološki proces	• tRNA 3'-trailer cleavage; • RNA phosphodiester bond hydrolysis, endonucleolytic; • tRNA processing; • tRNA 3'-trailer cleavage, endonucleolytic;
	Izvori:Amigo / QuickGO
Ortolozi
	55520
	114615
	ENSG00000141642
	ENSMUSG00000036941
	Q9H777
	Q8VEB6
	NM_018696
	NM_053255
	NP_061166
	NP_444485
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

ELAC protein 1 cink-fosfodiesteraze je enzim koji je kod ljudi kodiran genom ELAC1.^[5]^[6]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MSMDVTFLGT	GAAYPSPTRG	ASAVVLRCEG	ECWLFDCGEG	TQTQLMKSQL
KAGRITKIFI	THLHGDHFFG	LPGLLCTISL	QSGSMVSKQP	IEIYGPVGLR
DFIWRTMELS	HTELVFHYVV	HELVPTADQC	PAEELKEFAH	VNRADSPPKE
EQGRTILLDS	EENSYLLFDD	EQFVVKAFRL	FHRIPSFGFS	VVEKKRPGKL
NAQKLKDLGV	PPGPAYGKLK	NGISVVLENG	VTISPQDVLK	KPIVGRKICI
LGDCSGVVGD	GGVKLCFEAD	LLIHEATLDD	AQMDKAKEHG	HSTPQMAATF
AKLCRAKRLV	LTHFSQRYKP	VALAREGETD	GIAELKKQAE	SVLDLQEVTL
AEDFMVISIP	IKK

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141642 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036941 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takaku H, Minagawa A, Takagi M, Nashimoto M (Apr 2003). "A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease". Nucleic Acids Res. 31 (9): 2272–8. doi:10.1093/nar/gkg337. PMC 154223. PMID 12711671.
^ "Entrez Gene: ELAC1 elaC homolog 1 (E. coli)".

Dopunska literatura

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yanaihara N, Kohno T, Takakura S, et al. (2001). "Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus". Genomics. 72 (2): 169–79. doi:10.1006/geno.2000.6454. PMID 11401430.
Tavtigian SV, Simard J, Teng DH, et al. (2001). "A candidate prostate cancer susceptibility gene at chromosome 17p". Nat. Genet. 27 (2): 172–80. doi:10.1038/84808. PMID 11175785. S2CID 7889550.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141642 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036941 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12711671-5] Takaku H, Minagawa A, Takagi M, Nashimoto M (Apr 2003). "A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease". Nucleic Acids Res. 31 (9): 2272–8. doi:10.1093/nar/gkg337. PMC 154223. PMID 12711671.

[entrez-6] "Entrez Gene: ELAC1 elaC homolog 1 (E. coli)".

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