ECOP

ECOP
Identifikatori
Aliasi	VOPP1
Vanjski ID-jevi	OMIM: 611915 MGI: 2141658 HomoloGene: 12772 GeneCards: VOPP1
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	55,572,988 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	57,802,144 bp
Ontologija gena
Molekularna funkcija	• signal transducer activity;
Ćelijska komponenta	• integral component of membrane; • integral component of organelle membrane; • endozom; • cytoplasmic vesicle membrane; • membrana; • GO:0016023 citoplazmatska vezikula;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated;
	Izvori:Amigo / QuickGO
Ortolozi
	81552
	232023
	ENSG00000154978
	ENSMUSG00000037788
	Q96AW1
	Q8R1C3
NM_001284282; NM_001284283; NM_001284284; NM_030796; NM_001321242;
	NM_001321243; NM_001321244; NM_001321246; NM_001321247; NM_001321248; NM_001321249; NM_001321250; NM_001321251
	NM_146168
NP_001271211; NP_001271212; NP_001271213; NP_001308171; NP_001308172;
	NP_001308173; NP_001308175; NP_001308176; NP_001308177; NP_001308178; NP_001308179; NP_001308180; NP_110423
	NP_666280
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

EGFR- koamplificirani i preeksprimirani protein, takođe poznat i kao COP, jest ljudski gen.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 172 aminokiseline, а molekulska težina 19.224 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRRQPAKVAA	LLLGLLLECT	EAKKHCWYFE	GLYPTYYICR	SYEDCCGSRC
CVRALSIQRL	WYFWFLLMMG	VLFCCGAGFF	IRRRMYPPPL	IEEPAFNVSY
TRQPPNPGPG	AQQPGPPYYT	DPGGPGMNPV	GNSMAMAFQV	PPNSPQGSVA
CPPPPAYCNT	PPPPYEQVVK	AK

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154978 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037788 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ECOP EGFR-coamplified and overexpressed protein".
^ "UniProt, Q96AW1" (jezik: engleski). Pristupljeno 24. 9. 2021.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Park S, James CD (2005). "ECop (EGFR-coamplified and overexpressed protein), a novel protein, regulates NF-kappaB transcriptional activity and associated apoptotic response in an IkappaBalpha-dependent manner". Oncogene. 24 (15): 2495–502. doi:10.1038/sj.onc.1208496. PMID 15735698.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Brem H, Stojadinovic O, Diegelmann RF, et al. (2007). "Molecular Markers in Patients with Chronic Wounds to Guide Surgical Debridement". Mol. Med. 13 (1–2): 30–9. doi:10.2119/2006-00054.Brem. PMC 1869625. PMID 17515955.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154978 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037788 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ECOP EGFR-coamplified and overexpressed protein".

[UniProt-6] "UniProt, Q96AW1" (jezik: engleski). Pristupljeno 24. 9. 2021.

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