ECOP

EGFR- koamplificirani i preeksprimirani protein, takođe poznat i kao COP, jest ljudski gen.

ECOP
Identifikatori
Aliasi	VOPP1
Vanjski ID-jevi	OMIM: 611915 MGI: 2141658 HomoloGene: 12772 GeneCards: VOPP1
Lokacija gena (čovjek) Hrom. Hromosom 7 (čovjek) Bend 7p11.2 Početak 55,436,056 bp Kraj 55,572,988 bp
Lokacija gena (miš) Hrom. Hromosom 6 (miš) Bend 6|6 B3 Početak 57,704,792 bp Kraj 57,802,144 bp
Ontologija gena Molekularna funkcija • signal transducer activity Ćelijska komponenta • integral component of membrane • integral component of organelle membrane • endozom • cytoplasmic vesicle membrane • membrana • GO:0016023 citoplazmatska vezikula Biološki proces • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	81552	232023
Ensembl	ENSG00000154978	ENSMUSG00000037788
UniProt	Q96AW1	Q8R1C3
RefSeq (mRNK)	NM_001284282 NM_001284283 NM_001284284 NM_030796 NM_001321242 NM_001321243 NM_001321244 NM_001321246 NM_001321247 NM_001321248 NM_001321249 NM_001321250 NM_001321251	NM_146168
RefSeq (bjelančevina)	NP_001271211 NP_001271212 NP_001271213 NP_001308171 NP_001308172 NP_001308173 NP_001308175 NP_001308176 NP_001308177 NP_001308178 NP_001308179 NP_001308180 NP_110423	NP_666280
Lokacija (UCSC)	Chr 7: 55.44 – 55.57 Mb	Chr 6: 57.7 – 57.8 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 172 aminokiseline, а molekulska težina 19.224 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MRRQPAKVAA		LLLGLLLECT		EAKKHCWYFE		GLYPTYYICR		SYEDCCGSRC
CVRALSIQRL		WYFWFLLMMG		VLFCCGAGFF		IRRRMYPPPL		IEEPAFNVSY
TRQPPNPGPG		AQQPGPPYYT		DPGGPGMNPV		GNSMAMAFQV		PPNSPQGSVA
CPPPPAYCNT		PPPPYEQVVK		AK

Dopunska literatura

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• Park S, James CD (2005). "ECop (EGFR-coamplified and overexpressed protein), a novel protein, regulates NF-kappaB transcriptional activity and associated apoptotic response in an IkappaBalpha-dependent manner". Oncogene. 24 (15): 2495–502. doi:10.1038/sj.onc.1208496. PMID 15735698.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
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