DOM3Z
Protein Dom3Z jest protein koji je kod ljudi kodiran genom DOM3Z.[5][6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 396 aminokiselina, а molekulska težina 44.929 Da.[7]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MDPRGTKRGA | EKTEVAEPRN | KLPRPAPSLP | TDPALYSGPF | PFYRRPSELG | ||||
CFSLDAQRQY | HGDARALRYY | SPPPTNGPGP | NFDLRDGYPD | RYQPRDEEVQ | ||||
ERLDHLLCWL | LEHRGRLEGG | PGWLAEAIVT | WRGHLTKLLT | TPYERQEGWQ | ||||
LAASRFQGTL | YLSEVETPNA | RAQRLARPPL | LRELMYMGYK | FEQYMCADKP | ||||
GSSPDPSGEV | NTNVAFCSVL | RSRLGSHPLL | FSGEVDCTDP | QAPSTQPPTC | ||||
YVELKTSKEM | HSPGQWRSFY | RHKLLKWWAQ | SFLPGVPNVV | AGFRNPDGFV | ||||
SSLKTFPTMK | MFEYVRNDRD | GWNPSVCMNF | CAAFLSFAQS | TVVQDDPRLV | ||||
HLFSWEPGGP | VTVSVHQDAP | YAFLPIWYVE | AMTQDLPSPP | KTPSPK |
Funkcija
urediOvaj gen se lokalizira u glavnom kompleksu histokompatibilnosti (MHC) klase III na hromosomu 6. Funkcija njegovog proteinskog proizvoda je nepoznata, ali njegova sveprisutna ekspresija i konzeviranost i kod jednostavnih i kod složenih eukariota sugerira da bi to moglo biti domaćinski gen.[6]
Reference
uredi- ^ a b c ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 GRCh38: Ensembl release 89: ENSG00000204348, ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040482 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Yang Z, Shen L, Dangel AW, Wu LC, Yu CY (Dec 1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID 9799600.
- ^ a b "Entrez Gene: DOM3Z dom-3 homolog Z (C. elegans)".
- ^ "UniProt, O77932" (jezik: engleski). Pristupljeno 1. 10. 2021.
Dopunska literatura
uredi- Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster". Exp. Clin. Immunogenet. 15 (4): 213–30. doi:10.1159/000019075. PMID 10072631. S2CID 25061446.
- Yang Z, Yu CY (2000). "Organizations and gene duplications of the human and mouse MHC complement gene clusters". Exp. Clin. Immunogenet. 17 (1): 1–17. doi:10.1159/000019119. PMID 10686478. S2CID 45164668.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
- Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.