DMTF1

DMTF1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2LLK
Identifikatori
Aliasi	DMTF1
Vanjski ID-jevi	OMIM: 608491 MGI: 1344415 HomoloGene: 8017 GeneCards: DMTF1
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	87,196,337 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	9,211,776 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • vezivanje sa DNK; • sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific;
Ćelijska komponenta	• nukleoplazma; • citosol; • jedro;
Biološki proces	• ćelijski ciklus; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • Ćelijska diferencijacija; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	9988
	23857
	ENSG00000135164
	ENSMUSG00000042508
	Q9Y222
	Q8CE22
	NM_001142326; NM_001142327; NM_021145
	NM_001110327; NM_011806
	NP_001135798; NP_001135799; NP_066968
	NP_001103797; NP_035936
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Ciklin-D-vezujući myboliki transkripcijski faktor 1 je protein koji je kod ljudi kodiran genom DMTF1.^[5]^[6]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 760 aminokiselina, а molekulska težina 84.471 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSTVEEDSDT	VTVETVNSVT	LTQDTEGNLI	LHCPQNEADE	IDSEDSIEPP
HKRLCLSSED	DQSIDDSTPC	ISVVALPLSE	NDQSFEVTMT	ATTEVADDEV
TEGTVTQIQI	LQNEQLDEIS	PLGNEEVSAV	SQAWFTTKED	KDSLTNKGHK
WKQGMWSKEE	IDILMNNIER	YLKARGIKDA	TEIIFEMSKD	ERKDFYRTIA
WGLNRPLFAV	YRRVLRMYDD	RNHVGKYTPE	EIEKLKELRI	KHGNDWATIG
AALGRSASSV	KDRCRLMKDT	CNTGKWTEEE	EKRLAEVVHE	LTSTEPGDIV
TQGVSWAAVA	ERVGTRSEKQ	CRSKWLNYLN	WKQSGGTEWT	KEDEINLILR
IAELDVADEN	DINWDLLAEG	WSSVRSPQWL	RSKWWTIKRQ	IANHKDVSFP
VLIKGLKQLH	ENQKNNPTLL	ENKSGSGVPN	SNTNSSVQHV	QIRVARLEDN
TAISSSPMAA	LQIPVQITHV	SSADSPATVD	SETITLNSGT	LQTFEILPSF
HLQPTGTPGT	YLLQTSSSQG	LPLTLTASPT	VTLTAAAPAS	PEQIIVHALS
PEHLLNTSDN	VTVQCHTPRV	IIQTVATEDI	TSSISQAELT	VDSDIQSSDF
PEPPDALEAD	TFPDEIHHPK	MTVEPSFNDA	HVSKFSDQNS	TELMNSVMVR
TEEEISDTDL	KQEESPSDLA	SAYVTEGLES	PTIEEQVDQT	IDDETILIVP
SPHGFIQASD	VIDTESVLPL	TTLTDPILQH	HQEESNIIGS	SLGSPVSEDS
KDVEDLVNCH

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135164 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042508 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bodner SM, Naeve CW, Rakestraw KM, Jones BG, Valentine VA, Valentine MB, Luthardt FW, Willman CL, Raimondi SC, Downing JR, Roussel MF, Sherr CJ, Look AT (maj 1999). "Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1)". Gene. 229 (1–2): 223–8. doi:10.1016/S0378-1119(98)00591-5. PMID 10095122.
^ "Entrez Gene: DMTF1 cyclin D binding myb-like transcription factor 1".
^ "UniProt, Q9Y222" (jezik: engleski). Pristupljeno 24. 9. 2021.

Dopunska literatura uredi

Försti A, Angelini S, Festa F, et al. (2004). "Single nucleotide polymorphisms in breast cancer". Oncol. Rep. 11 (4): 917–22. doi:10.3892/or.11.4.917. PMID 15010895.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Tschan MP, Fischer KM, Fung VS, et al. (2003). "Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns". J. Biol. Chem. 278 (44): 42750–60. doi:10.1074/jbc.M307067200. PMID 12917399.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
<Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Inoue K, Sherr CJ, Shapiro LH (1998). "Regulation of the CD13/aminopeptidase N gene by DMP1, a transcription factor antagonized by D-type cyclins". J. Biol. Chem. 273 (44): 29188–94. doi:10.1074/jbc.273.44.29188. PMID 9786929.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Hirai H, Sherr CJ (1996). "Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1". Mol. Cell. Biol. 16 (11): 6457–67. doi:10.1128/MCB.16.11.6457. PMC 231647. PMID 8887674.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135164 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042508 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10095122-5] Bodner SM, Naeve CW, Rakestraw KM, Jones BG, Valentine VA, Valentine MB, Luthardt FW, Willman CL, Raimondi SC, Downing JR, Roussel MF, Sherr CJ, Look AT (maj 1999). "Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1)". Gene. 229 (1–2): 223–8. doi:10.1016/S0378-1119(98)00591-5. PMID 10095122.

[entrez-6] "Entrez Gene: DMTF1 cyclin D binding myb-like transcription factor 1".

[UniProt-7] "UniProt, Q9Y222" (jezik: engleski). Pristupljeno 24. 9. 2021.

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