DKK3

Dickkopfu-srodni protein 3 je protein porodice Dickkopf koji je kod ljudi kodiran genom DKK3.

DKK3
Identifikatori
Aliasi	DKK3
Vanjski ID-jevi	OMIM: 605416 MGI: 1354952 HomoloGene: 8303 GeneCards: DKK3
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek) Bend 11p15.3 Početak 11,956,207 bp Kraj 12,009,769 bp
Lokacija gena (miš) Hrom. Hromosom 7 (miš) Bend 7|7 F1 Početak 111,715,224 bp Kraj 111,758,264 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • co-receptor binding • receptor antagonist activity Ćelijska komponenta • extracellular region • Vanćelijsko Biološki proces • negative regulation of anti-Mullerian hormone signaling pathway • multicellular organism development • negative regulation of cortisol biosynthetic process • negative regulation of Wnt signaling pathway • anatomical structure morphogenesis • GO:0045996 negative regulation of transcription, DNA-templated • Wnt-signalni put • adrenal gland development • negative regulation of canonical Wnt signaling pathway • regulation of transforming growth factor beta receptor signaling pathway • negative regulation of aldosterone biosynthetic process • extracellular negative regulation of signal transduction • negative regulation of signaling receptor activity Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	27122	50781
Ensembl	ENSG00000050165	ENSMUSG00000030772
UniProt	Q9UBP4	Q9QUN9
RefSeq (mRNK)	NM_001018057 NM_013253 NM_015881 NM_001330220	NM_015814 NM_001360257 NM_001360260 NM_001360261
RefSeq (bjelančevina)	NP_001018067 NP_001317149 NP_037385 NP_056965	NP_056629 NP_001347186 NP_001347189 NP_001347190
Lokacija (UCSC)	Chr 11: 11.96 – 12.01 Mb	Chr 7: 111.72 – 111.76 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 350 aminokiselina, a molekulska težina 38.390 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MQRLGATLLC		LLLAAAVPTA		PAPAPTATSA		PVKPGPALSY		PQEEATLNEM
FREVEELMED		TQHKLRSAVE		EMEAEEAAAK		ASSEVNLANL		PPSYHNETNT
DTKVGNNTIH		VHREIHKITN		NQTGQMVFSE		TVITSVGDEE		GRRSHECIID
EDCGPSMYCQ		FASFQYTCQP		CRGQRMLCTR		DSECCGDQLC		VWGHCTKMAT
RGSNGTICDN		QRDCQPGLCC		AFQRGLLFPV		CTPLPVEGEL		CHDPASRLLD
LITWELEPDG		ALDRCPCASG		LLCQPHSHSL		VYVCKPTFVG		SRDQDGEILL
PREVPDEYEV		GSFMEEVRQE		LEDLERSLTE		EMALREPAAA		AAALLGGEEI

Funkcija

Ovaj gen kodira protein koji je član porodice dickkopf. Izlučeni protein sadrži dvije regije bogate cisteinom i uključen je u razvoj embriona kroz interakcije sa signalnim putem Wnt. Ekspresija ovog gena je smanjena u različitim linijama ćelija raka i može funkcionirati kao genski supresor tumora. alternativna prerada rezultira u više varijanti transkripta koje kodiraju isti protein.

Dopunska literatuera

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