Dickkopfu-srodni protein 3 je protein porodice Dickkopf koji je kod ljudi kodiran genom DKK3.[5][6]

DKK3
Identifikatori
AliasiDKK3
Vanjski ID-jeviOMIM: 605416 MGI: 1354952 HomoloGene: 8303 GeneCards: DKK3
Lokacija gena (čovjek)
Hromosom 11 (čovjek)
Hrom.Hromosom 11 (čovjek)[1]
Hromosom 11 (čovjek)
Genomska lokacija za DKK3
Genomska lokacija za DKK3
Bend11p15.3Početak11,956,207 bp[1]
Kraj12,009,769 bp[1]
Lokacija gena (miš)
Hromosom 7 (miš)
Hrom.Hromosom 7 (miš)[2]
Hromosom 7 (miš)
Genomska lokacija za DKK3
Genomska lokacija za DKK3
Bend7|7 F1Početak111,715,224 bp[2]
Kraj111,758,264 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija co-receptor binding
receptor antagonist activity
Ćelijska komponenta extracellular region
Vanćelijsko
Biološki proces negative regulation of anti-Mullerian hormone signaling pathway
multicellular organism development
negative regulation of cortisol biosynthetic process
negative regulation of Wnt signaling pathway
anatomical structure morphogenesis
GO:0045996 negative regulation of transcription, DNA-templated
Wnt-signalni put
adrenal gland development
negative regulation of canonical Wnt signaling pathway
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of aldosterone biosynthetic process
extracellular negative regulation of signal transduction
negative regulation of signaling receptor activity
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001018057
NM_013253
NM_015881
NM_001330220

NM_015814
NM_001360257
NM_001360260
NM_001360261

RefSeq (bjelančevina)

NP_001018067
NP_001317149
NP_037385
NP_056965

NP_056629
NP_001347186
NP_001347189
NP_001347190

Lokacija (UCSC)Chr 11: 11.96 – 12.01 MbChr 7: 111.72 – 111.76 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 350 aminokiselina, a molekulska težina 38.390 Da.[7]

1020304050
MQRLGATLLCLLLAAAVPTAPAPAPTATSAPVKPGPALSYPQEEATLNEM
FREVEELMEDTQHKLRSAVEEMEAEEAAAKASSEVNLANLPPSYHNETNT
DTKVGNNTIHVHREIHKITNNQTGQMVFSETVITSVGDEEGRRSHECIID
EDCGPSMYCQFASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMAT
RGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLD
LITWELEPDGALDRCPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILL
PREVPDEYEVGSFMEEVRQELEDLERSLTEEMALREPAAAAAALLGGEEI

[6]

Funkcija uredi

Ovaj gen kodira protein koji je član porodice dickkopf. Izlučeni protein sadrži dvije regije bogate cisteinom i uključen je u razvoj embriona kroz interakcije sa signalnim putem Wnt. Ekspresija ovog gena je smanjena u različitim linijama ćelija raka i može funkcionirati kao genski supresor tumora. alternativna prerada rezultira u više varijanti transkripta koje kodiraju isti protein.[6]

Reference uredi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000050165 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030772 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, et al. (oktobar 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958.
  6. ^ a b c "Entrez Gene: DKK3 dickkopf homolog 3 (Xenopus laevis)".
  7. ^ "UniProt, Q9UBP4". Pristupljeno 20. 8. 2021.

Dopunska literatuera uredi