DENND1A

Protein 1A sa DENN-domenom jest protein koji je kod ljudi kodiran genom DENND1A.

DENND1A
Identifikatori
Aliasi	DENND1A
Vanjski ID-jevi	OMIM: 613633 MGI: 2442794 HomoloGene: 17141 GeneCards: DENND1A
Lokacija gena (čovjek) Hrom. Hromosom 9 (čovjek) Bend 9q33.3 Početak 123,379,654 bp Kraj 123,930,152 bp
Lokacija gena (miš) Hrom. Hromosom 2 (miš) Bend 2|2 B Početak 37,689,003 bp Kraj 38,177,402 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • guanyl-nucleotide exchange factor activity • SH3 domain binding • lipid binding • phosphatidylinositol phosphate binding • phosphatidylinositol-3-phosphate binding Ćelijska komponenta • membrana • ćelijska membrana • sinapsa • međućelijske veze • neuronal cell body • dendrit • clathrin-coated vesicle membrane • presynaptic membrane • GO:0016023 citoplazmatska vezikula • clathrin-coated vesicle • nukleoplazma • citosol • intracellular membrane-bounded organelle Biološki proces • Endocitoza • regulation of Rab protein signal transduction • synaptic vesicle endocytosis • protein transport • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • endocytic recycling Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	57706	227801
Ensembl	ENSG00000119522	ENSMUSG00000035392
UniProt	Q8TEH3	Q8K382
RefSeq (mRNK)	NM_020946 NM_024820 NM_001352964 NM_001352965 NM_001352966 NM_001352967 NM_001352968 NM_001393654 NM_001400446 NM_001400449	NM_146122 NM_001362973 NM_001362977 NM_001362978
RefSeq (bjelančevina)	NP_065997 NP_079096 NP_001339893 NP_001339894 NP_001339895 NP_001339896 NP_001339897	NP_666234 NP_001349902 NP_001349906 NP_001349907
Lokacija (UCSC)	Chr 9: 123.38 – 123.93 Mb	Chr 2: 37.69 – 38.18 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.109 aminokiselina, а molekulska težina 110.577 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MGSRIKQNPE		TTFEVYVEVA		YPRTGGTLSD		PEVQRQFPED		YSDQEVLQTL
TKFCFPFYVD		SLTVSQVGQN		FTFVLTDIDS		KQRFGFCRLS		SGAKSCFCIL
SYLPWFEVFY		KLLNILADYT		TKRQENQWNE		LLETLHKLPI		PDPGVSVHLS
VHSYFTVPDT		RELPSIPENR		NLTEYFVAVD		VNNMLHLYAS		MLYERRILII
CSKLSTLTAC		IHGSAAMLYP		MYWQHVYIPV		LPPHLLDYCC		APMPYLIGIH
LSLMEKVRNM		ALDDVVILNV		DTNTLETPFD		DLQSLPNDVI		SSLKNRLKKV
STTTGDGVAR		AFLKAQAAFF		GSYRNALKIE		PEEPITFCEE		AFVSHYRSGA
MRQFLQNATQ		LQLFKQFIDG		RLDLLNSGEG		FSDVFEEEIN		MGEYAGSDKL
YHQWLSTVRK		GSGAILNTVK		TKANPAMKTV		YKFAKDHAKM		GIKEVKNRLK
QKDIAENGCA		PTPEEQLPKT		APSPLVEAKD		PKLREDRRPI		TVHFGQVRPP
RPHVVKRPKS		NIAVEGRRTS		VPSPEQPQPY		RTLRESDSAE		GDEAESPEQQ
VRKSTGPVPA		PPDRAASIDL		LEDVFSNLDM		EAALQPLGQA		KSLEDLRAPK
DLREQPGTFD		YQRLDLGGSE		RSRGVTVALK		LTHPYNKLWS		LGQDDMAIPS
KPPAASPEKP		SALLGNSLAL		PRRPQNRDSI		LNPSDKEEVP		TPTLGSITIP
RPQGRKTPEL		GIVPPPPIPR		PAKLQAAGAA		LGDVSERLQT		DRDRRAALSP
GLLPGVVPQG		PTELLQPLSP		GPGAAGTSSD		ALLALLDPLS		TAWSGSTLPS
RPATPNVATP		FTPQFSFPPA		GTPTPFPQPP		LNPFVPSMPA		APPTLPLVST
PAGPFGAPPA		SLGPAFASGL		LLSSAGFCAP		HRSQPNLSAL		SMPNLFGQMP
MGTHTSPLQP		LGPPAVAPSR		IRTLPLARSS		ARAAETKQGL		ALRPGDPPLL
PPRPPQGLEP		TLQPSAPQQA		RDPFEDLLQK		TKQDVSPSPA		LAPAPDSVEQ
LRKQWETFE

Dopunska literatura

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.