DDX52

DDX52
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3DKP
Identifikatori
Aliasi	DDX52
Vanjski ID-jevi	OMIM: 612500 MGI: 1925644 HomoloGene: 5093 GeneCards: DDX52
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	37,643,446 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	83,853,914 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • hydrolase activity; • ATP binding; • GO:0008026 helicase activity; • nucleic acid binding; • vezivanje sa RNK;
Ćelijska komponenta	• membrana; • nukleoplazma; • jedro; • Jedarce; • citoplazma;
Biološki proces	• RNA secondary structure unwinding; • rRNA processing;
	Izvori:Amigo / QuickGO
Ortolozi
	11056
	78394
	ENSG00000277594; ENSG00000278053
	ENSMUSG00000020677
	Q9Y2R4
	Q8K301
	NM_001291476; NM_007010; NM_152300
	NM_030096
	NP_001278405; NP_008941
	NP_084372
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Vjerovatna ATP-ovisna RNK-helikaza DDX52 je enzim koji je kod ljudi kodiran genom DDX52.^[5]^[6]

Pretragom EST baza podataka koristeći otvoreni okvir čitanja (ORF) S. cerevisiae, Stanchi et al. (2001) identificirali su DDX52, kojeg su nazvali HUSSY19. Izvedeni protein sa 420 aminokiselina dijeli 45% identiteta s kvaščevim Rok1, navodnom ATP-ovisnom RNK-helikazom iz boksne porodice DEAD. Radijacijskom hibridnom analizom, mapirali su gen DDX52 u hromosomskoj regijiom 17q21.1.^[7]

Dužina polipeptidnog lanca je 599 aminokiselina, a molekulska težina 67.498 Da.^[8]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MDVHDLFRRL	GAGAKFDTRR	FSADAARFQI	GKRKYDFDSS	EVLQGLDFFG
NKKSVPGVCG	ASQTHQKPQN	GEKKEESLTE	RKREQSKKKR	KTMTSEIASQ
EEGATIQWMS	SVEAKIEDKK	VQRESKLTSG	KLENLRKEKI	NFLRNKHKIH
VQGTDLPDPI	ATFQQLDQEY	KINSRLLQNI	LDAGFQMPTP	IQMQAIPVML
HGRELLASAP	TGSGKTLAFS	IPILMQLKQP	ANKGFRALII	SPTRELASQI
HRELIKISEG	TGFRIHMIHK	AAVAAKKFGP	KSSKKFDILV	TTPNRLIYLL
KQDPPGIDLA	SVEWLVVDES	DKLFEDGKTG	FRDQLASIFL	ACTSHKVRRA
MFSATFAYDV	EQWCKLNLDN	VISVSIGARN	SAVETVEQEL	LFVGSETGKL
LAMRELVKKG	FNPPVLVFVQ	SIERAKELFH	ELIYEGINVD	VIHAERTQQQ
RDNTVHSFRA	GKIWVLICTA	LLARGIDFKG	VNLVINYDFP	TSSVEYIHRI
GRTGRAGNKG	KAITFFTEDD	KPLLRSVANV	IQQAGCPVPE	YIKGFQKLLS
KQKKKMIKKP	LERESISTTP	KCFLEKAKDK	QKKVTGQNSK	KKVALEDKS

Reference

^ ^a ^b ^c ENSG00000278053 GRCh38: Ensembl release 89: ENSG00000277594, ENSG00000278053 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020677 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (Jan 2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703.
^ "Entrez Gene: DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52".
^ Stanchi, F., Bertocco, E., Toppo, S., Dioguardi, R., Simionati, B., Cannata, N., Zimbello, R., Lanfranchi, G., Valle, G. Characterization of 16 novel human genes showing high similarity to yeast sequences. Yeast 18: 69-80, 2001. PubMed: 11124703
^ "UniProt, Q9Y2R4". Pristupljeno 22. 6. 2021.

Dopunska literatura

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.

[refGRCh38Ensembl-1] ENSG00000278053 GRCh38: Ensembl release 89: ENSG00000277594, ENSG00000278053 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020677 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11124703-5] Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (Jan 2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703.

[entrez-6] "Entrez Gene: DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52".

[7] Stanchi, F., Bertocco, E., Toppo, S., Dioguardi, R., Simionati, B., Cannata, N., Zimbello, R., Lanfranchi, G., Valle, G. Characterization of 16 novel human genes showing high similarity to yeast sequences. Yeast 18: 69-80, 2001. PubMed: 11124703

[UniProt-8] "UniProt, Q9Y2R4". Pristupljeno 22. 6. 2021.

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