Dendrocitno eksprimirani sedmotransmembranski protein je protein koji je kod ljudi kodiran genom DCSTAMP.[5]

DCSTAMP
Identifikatori
AliasiDCSTAMP
Vanjski ID-jeviOMIM: 605933 MGI: 1923016 HomoloGene: 12769 GeneCards: DCSTAMP
Lokacija gena (čovjek)
Hromosom 8 (čovjek)
Hrom.Hromosom 8 (čovjek)[1]
Hromosom 8 (čovjek)
Genomska lokacija za DCSTAMP
Genomska lokacija za DCSTAMP
Bend8q22.3Početak104,339,087 bp[1]
Kraj104,356,689 bp[1]
Lokacija gena (miš)
Hromosom 15 (miš)
Hrom.Hromosom 15 (miš)[2]
Hromosom 15 (miš)
Genomska lokacija za DCSTAMP
Genomska lokacija za DCSTAMP
Bend15|15 B3.1Početak39,609,326 bp[2]
Kraj39,624,334 bp[2]
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 protein binding
Ćelijska komponenta integral component of membrane
endozom
endoplasmic reticulum membrane
membrana
Ćelijska membrana
cell surface
integral component of endoplasmic reticulum membrane
Endoplazmatski retikulum
endosome membrane
endoplasmic reticulum-Golgi intermediate compartment membrane
Biološki proces cellular response to interleukin-4
Ćelijska diferencijacija
immune system process
osteoclast differentiation
cellular response to tumor necrosis factor
membrane fusion
myeloid dendritic cell differentiation
positive regulation of bone resorption
positive regulation of macrophage fusion
cellular response to macrophage colony-stimulating factor stimulus
osteoclast fusion
negative regulation of cell growth
positive regulation of monocyte differentiation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001257317
NM_030788

NM_001289506
NM_001289508
NM_001289512
NM_001289513
NM_029422

RefSeq (bjelančevina)

NP_001244246
NP_110415

NP_001276435
NP_001276437
NP_001276441
NP_001276442
NP_083698

Lokacija (UCSC)Chr 8: 104.34 – 104.36 MbChr 15: 39.61 – 39.62 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 470 aminokiselina, а molekulska težina 53.393 Da.[6]

1020304050
MGIWTSGTDIFLSLWEIYVSPRSPGWMDFIQHLGVCCLVALISVGLLSVA
ACWFLPSIIAAAASWIITCVLLCCSKHARCFILLVFLSCGLREGRNALIA
AGTGIVILGHVENIFHNFKGLLDGMTCNLRAKSFSIHFPLLKKYIEAIQW
IYGLATPLSVFDDLVSWNQTLAVSLFSPSHVLEAQLNDSKGEVLSVLYQM
ATTTEVLSSLGQKLLAFAGLSLVLLGTGLFMKRFLGPCGWKYENIYITRQ
FVQFDERERHQQRPCVLPLNKEERRKYVIIPTFWPTPKERKNLGLFFLPI
LIHLCIWVLFAAVDYLLYRLIFSVSKQFQSLPGFEVHLKLHGEKQGTQDI
IHDSSFNISVFEPNCIPKPKFLLSETWVPLSVILLILVMLGLLSSILMQL
KILVSASFYPSVERKRIQYLHAKLLKKRSKQPLGEVKRRLSLYLTKIHFW
LPVLKMIRKKQMDMASADKS

Funkcija uredi

Ovaj gen kodira sa sedmoprolazni transmembranski protein koji se primarno eksprimira u dendritskim ćelijama. Kodirani protein uključen je u niz imunskih funkcija dendritskih ćelija. Ovaj protein ima ulogu u osteoklastogenezi i mijeloidnoj diferencijaciji. Alternativna prerada rezultira u više varijanti transkripta (prema RefSeq, mart 2012).

Reference uredi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164935 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022303 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Dendrocyte expressed seven transmembrane protein".
  6. ^ "UniProt, Q9H295" (jezik: engleski). Pristupljeno 16. 9. 2021.

Dopunska literatura uredi