DCSTAMP

Dendrocitno eksprimirani sedmotransmembranski protein je protein koji je kod ljudi kodiran genom DCSTAMP.

DCSTAMP
Identifikatori
Aliasi	DCSTAMP
Vanjski ID-jevi	OMIM: 605933 MGI: 1923016 HomoloGene: 12769 GeneCards: DCSTAMP
Lokacija gena (čovjek) Hrom. Hromosom 8 (čovjek) Bend 8q22.3 Početak 104,339,087 bp Kraj 104,356,689 bp
Lokacija gena (miš) Hrom. Hromosom 15 (miš) Bend 15|15 B3.1 Početak 39,609,326 bp Kraj 39,624,334 bp
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • integral component of membrane • endozom • endoplasmic reticulum membrane • membrana • ćelijska membrana • cell surface • integral component of endoplasmic reticulum membrane • Endoplazmatski retikulum • endosome membrane • endoplasmic reticulum-Golgi intermediate compartment membrane Biološki proces • cellular response to interleukin-4 • Ćelijska diferencijacija • immune system process • osteoclast differentiation • cellular response to tumor necrosis factor • membrane fusion • myeloid dendritic cell differentiation • positive regulation of bone resorption • positive regulation of macrophage fusion • cellular response to macrophage colony-stimulating factor stimulus • osteoclast fusion • negative regulation of cell growth • positive regulation of monocyte differentiation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	81501	75766
Ensembl	ENSG00000164935	ENSMUSG00000022303
UniProt	Q9H295	Q7TNJ0
RefSeq (mRNK)	NM_001257317 NM_030788	NM_001289506 NM_001289508 NM_001289512 NM_001289513 NM_029422
RefSeq (bjelančevina)	NP_001244246 NP_110415	NP_001276435 NP_001276437 NP_001276441 NP_001276442 NP_083698
Lokacija (UCSC)	Chr 8: 104.34 – 104.36 Mb	Chr 15: 39.61 – 39.62 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 470 aminokiselina, а molekulska težina 53.393 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MGIWTSGTDI		FLSLWEIYVS		PRSPGWMDFI		QHLGVCCLVA		LISVGLLSVA
ACWFLPSIIA		AAASWIITCV		LLCCSKHARC		FILLVFLSCG		LREGRNALIA
AGTGIVILGH		VENIFHNFKG		LLDGMTCNLR		AKSFSIHFPL		LKKYIEAIQW
IYGLATPLSV		FDDLVSWNQT		LAVSLFSPSH		VLEAQLNDSK		GEVLSVLYQM
ATTTEVLSSL		GQKLLAFAGL		SLVLLGTGLF		MKRFLGPCGW		KYENIYITRQ
FVQFDERERH		QQRPCVLPLN		KEERRKYVII		PTFWPTPKER		KNLGLFFLPI
LIHLCIWVLF		AAVDYLLYRL		IFSVSKQFQS		LPGFEVHLKL		HGEKQGTQDI
IHDSSFNISV		FEPNCIPKPK		FLLSETWVPL		SVILLILVML		GLLSSILMQL
KILVSASFYP		SVERKRIQYL		HAKLLKKRSK		QPLGEVKRRL		SLYLTKIHFW
LPVLKMIRKK		QMDMASADKS

Funkcija

Ovaj gen kodira sa sedmoprolazni transmembranski protein koji se primarno eksprimira u dendritskim ćelijama. Kodirani protein uključen je u niz imunskih funkcija dendritskih ćelija. Ovaj protein ima ulogu u osteoklastogenezi i mijeloidnoj diferencijaciji. Alternativna prerada rezultira u više varijanti transkripta (prema RefSeq, mart 2012).

Dopunska literatura

• Lee KY, Huang SM, Li S, Kim JM (februar 2009). "Identification of differentially expressed genes in papillary thyroid cancers". Yonsei Medical Journal. 50 (1): 60–7. doi:10.3349/ymj.2009.50.1.60. PMC 2649849. PMID 19259350.
• Sakai H, Okafuji I, Nishikomori R, Abe J, Izawa K, Kambe N, Yasumi T, Nakahata T, Heike T (januar 2012). "The CD40-CD40L axis and IFN-γ play critical roles in Langhans giant cell formation". International Immunology. 24 (1): 5–15. doi:10.1093/intimm/dxr088. PMID 22058328.
• Eleveld-Trancikova D, Triantis V, Moulin V, Looman MW, Wijers M, Fransen JA, Lemckert AA, Havenga MJ, Figdor CG, Janssen RA, Adema GJ (mart 2005). "The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum". Journal of Leukocyte Biology. 77 (3): 337–43. doi:10.1189/jlb.0804441. PMID 15601667. S2CID 34646103.
• Beauregard M, Gagnon E, Guay-Bélanger S, Morissette J, Brown JP, Michou L (juni 2014). "Identification of rare genetic variants in novel loci associated with Paget's disease of bone". Human Genetics. 133 (6): 755–68. doi:10.1007/s00439-013-1409-x. PMID 24370779. S2CID 15972393.
• Kim HY, Cho S, Yu J, Sung S, Kim H (august 2010). "Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT". BMB Reports. 43 (8): 547–53. doi:10.5483/bmbrep.2010.43.8.547. PMID 20797317.
• Eleveld-Trancikova D, Sanecka A, van Hout-Kuijer MA, Looman MW, Hendriks IA, Jansen BJ, Adema GJ (juli 2010). "DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation". Molecular Immunology. 47 (11–12): 1963–73. doi:10.1016/j.molimm.2010.04.019. PMID 20546900.
• Zeng Z, Zhang C, Chen J (juli 2013). "Lentivirus-mediated RNA interference of DC-STAMP expression inhibits the fusion and resorptive activity of human osteoclasts". Journal of Bone and Mineral Metabolism. 31 (4): 409–16. doi:10.1007/s00774-013-0434-0. PMID 23525827. S2CID 22750579.
• Hartgers FC, Looman MW, van der Woning B, Merkx GF, Figdor CG, Adema GJ (mart 2001). "Genomic organization, chromosomal localization, and 5' upstream region of the human DC-STAMP gene". Immunogenetics. 53 (2): 145–9. doi:10.1007/s002510100302. PMID 11345591. S2CID 2780913.
• Chiu YH, Mensah KA, Schwarz EM, Ju Y, Takahata M, Feng C, McMahon LA, Hicks DG, Panepento B, Keng PC, Ritchlin CT (januar 2012). "Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP)". Journal of Bone and Mineral Research. 27 (1): 79–92. doi:10.1002/jbmr.531. PMC 3304467. PMID 21987375.