CRACR2A

Kanalski regulator 2A otpuštanja aktiviranog kalcija je protein koji je kod ljudi kodiran genom CRACR2A.

CRACR2A
Identifikatori
Aliasi	CRACR2A
Vanjski ID-jevi	OMIM: 614178 MGI: 2685919 HomoloGene: 41883 GeneCards: CRACR2A
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek) Bend 12p13.32 Početak 3,606,633 bp Kraj 3,764,819 bp
Lokacija gena (miš) Hrom. Hromosom 6 (miš) Bend 6|6 F3 Početak 127,538,301 bp Kraj 127,651,211 bp
Ontologija gena Molekularna funkcija • vezivanje iona metala • calcium ion binding • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • citoplazma • membrana • extracellular region • specific granule lumen Biološki proces • ion transport • adaptive immune response • activation of store-operated calcium channel activity • calcium ion transport • store-operated calcium entry • positive regulation of calcium ion transport • immune system process • neutrophil degranulation • GO:0015915 transport Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	84766	381812
Ensembl	ENSG00000130038	ENSMUSG00000061414
UniProt	Q9BSW2	Q3UP38
RefSeq (mRNK)	NM_001144958 NM_001144959 NM_032680	NM_001033464 NM_001368877
RefSeq (bjelančevina)	NP_001138430 NP_116069	NP_001028636 NP_001355806
Lokacija (UCSC)	Chr 12: 3.61 – 3.76 Mb	Chr 6: 127.54 – 127.65 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 395 aminokiselina, a molekulska težina 45.592 Da..

10		20		30		40		50
MAAPDGRVVS		RPQRLGQGSG		QGPKGSGACL		HPLDSLEQKE		TQEQTSGQLV
MLRKAQEFFQ		TCDAEGKGFI		ARKDMQRLHK		ELPLSLEELE		DVFDALDADG
NGYLTPQEFT		TGFSHFFFSQ		NNPSQEDAGE		QVAQRHEEKV		YLSRGDEDLG
DMGEDEEAQF		RMLMDRLGAQ		KVLEDESDVK		QLWLQLKKEE		PHLLSNFEDF
LTRIISQLQE		AHEEKNELEC		ALKRKIAAYD		EEIQHLYEEM		EQQIKSEKEQ
FLLKDTERFQ		ARSQELEQKL		LCKEQELEQL		TQKQKRLEGQ		CTALHHDKHE
TKAENTKLKL		TNQELARELE		RTSWELQDAQ		QQLESLQQEA		CKLHQEKEME
VYRVTESLQR		EKAGLLKQLD		FLRCVGGHWP		VLRAPPRSLG		SEGPV

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Dopunska literatura

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y (2010). "A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells". Nat. Cell Biol. 12 (5): 436–46. doi:10.1038/ncb2045. PMC 2875865. PMID 20418871.
• Chalasani N, Guo X, Loomba R, Goodarzi MO, Haritunians T, Kwon S, Cui J, Taylor KD, Wilson L, Cummings OW, Chen YD, Rotter JI (2010). "Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease". Gastroenterology. 139 (5): 1567–76, 1576.e1–6. doi:10.1053/j.gastro.2010.07.057. PMC 2967576. PMID 20708005.