CHMP5

CHMP5
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2LXM, 3ULY, 3UM0, 3UM1, 3UM2, 4TXR
Identifikatori
Aliasi	CHMP5
Vanjski ID-jevi	OMIM: 610900 MGI: 1924209 HomoloGene: 5757 GeneCards: CHMP5
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	40,965,303 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • cadherin binding;
Ćelijska komponenta	• citoplazma; • citosol; • endozom; • membrana; • endosome membrane; • Egzosom; • jedro;
Biološki proces	• regulation of centrosome duplication; • GO:0019067 viral life cycle; • nucleus organization; • multivesicular body sorting pathway; • endosome to lysosome transport; • multivesicular body assembly; • regulation of mitotic spindle assembly; • endosomal transport; • protein transport; • septum digestion after cytokinesis; • mitotic metaphase plate congression; • regulation of receptor recycling; • lysosome organization; • vacuolar transport; • ESCRT III complex disassembly; • GO:0015915 transport; • midbody abscission; • cellular response to lipopolysaccharide; • cellular response to muramyl dipeptide;
	Izvori:Amigo / QuickGO
Ortolozi
	51510
	76959
	n/a
	ENSMUSG00000028419
	Q9NZZ3
	Q9D7S9
	NM_016410; NM_001195536
	NM_029814
	NP_001182465; NP_057494
	NP_084090
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Naelektrizirani multivezikulski tjelesni protein 5 je protein koji je kod ljudi kodiran genom CHMP5.^[4]^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 219 aminokiselina, а molekulska težina 24.571 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MNRLFGKAKP	KAPPPSLTDC	IGTVDSRAES	IDKKISRLDA	ELVKYKDQIK
KMREGPAKNM	VKQKALRVLK	QKRMYEQQRD	NLAQQSFNME	QANYTIQSLK
DTKTTVDAMK	LGVKEMKKAY	KQVKIDQIED	LQDQLEDMME	DANEIQEALS
RSYGTPELDE	DDLEAELDAL	GDELLADEDS	SYLDEAASAP	AIPEGVPTDT
KNKDGVLVDE	FGLPQIPAS

Funkcija

CHMP5 pripada porodici hromatin-modificirajućih proteina/porodica nabijenih multivazikulskih tjelesnih proteina (CHMP). Ovi proteini su komponente ESCRT-III (kompleks endosomnog sortiranja potreban za transport III), kompleksa uključenog u razgradnju površinskih receptorskih proteina i formiranje endocitnih multivezikulnih tijela (MVB). Neki CHMP-i imaju i jedarnu i citoplazmatsku/vezikulnu raspodjelu, a jedan takav CHMP, CHMP1A, potreban je i za stvaranje MVB-a i za regulaciju progresije ćelijskog ciklusa.^[6]^[8]

Reference

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028419 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ward DM, Vaughn MB, Shiflett SL, White PL, Pollock AL, Hill J, Schnegelberger R, Sundquist WI, Kaplan J (Mar 2005). "The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells". J Biol Chem. 280 (11): 10548–55. doi:10.1074/jbc.M413734200. PMID 15644320.
^ Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (Sep 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J Cell Sci. 114 (Pt 13): 2395–404. doi:10.1242/jcs.114.13.2395. PMID 11559748.
^ ^a ^b "Entrez Gene: CHMP5 chromatin modifying protein 5".
^ "UniProt, Q9NZZ3". Pristupljeno 7. 9. 2021.
^ Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM (septembar 2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.

Dopunska literatura

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Vanjski linkovi

Lokacija ljudskog genoma CHMP5 i stranica sa detaljima o genu CHMP5 u UCSC Genome Browseru.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000028419 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15644320-4] Ward DM, Vaughn MB, Shiflett SL, White PL, Pollock AL, Hill J, Schnegelberger R, Sundquist WI, Kaplan J (Mar 2005). "The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells". J Biol Chem. 280 (11): 10548–55. doi:10.1074/jbc.M413734200. PMID 15644320.

[pmid11559748-5] Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (Sep 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J Cell Sci. 114 (Pt 13): 2395–404. doi:10.1242/jcs.114.13.2395. PMID 11559748.

[entrez-6] "Entrez Gene: CHMP5 chromatin modifying protein 5".

[UniProt-7] "UniProt, Q9NZZ3". Pristupljeno 7. 9. 2021.

[pmid16730941-8] Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM (septembar 2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.

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