ARPP-19

ARPP-19
Identifikatori
Aliasi	ARPP19
Vanjski ID-jevi	OMIM: 605487 MGI: 1891691 HomoloGene: 21318 GeneCards: ARPP19
Lokacija gena (čovjek)
Hrom.	Hromosom 15 (čovjek)
Kraj	52,569,883 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	75,060,313 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• protein phosphatase 2A binding; • potassium channel regulator activity; • signaling receptor binding; • phosphatase inhibitor activity; • protein phosphatase inhibitor activity; • protein phosphatase regulator activity;
Ćelijska komponenta	• nukleoplazma; • citoplazma;
Biološki proces	• Ćelijska dioba; • positive regulation of glucose import; • ćelijski ciklus; • positive regulation of gluconeogenesis; • G2/M transition of mitotic cell cycle; • GO:0048553 negative regulation of catalytic activity; • negative regulation of protein dephosphorylation; • GO:0007067 Mitoza; • negative regulation of phosphoprotein phosphatase activity; • regulation of phosphoprotein phosphatase activity;
	Izvori:Amigo / QuickGO
Ortolozi
	10776
	59046
	ENSG00000128989
	ENSMUSG00000007656
	P56211
	P56212
	NM_001306191; NM_001306195; NM_001306196; NM_006628; NM_001330309
	NM_001142655; NM_021548
	NP_001293120; NP_001293124; NP_001293125; NP_001317238; NP_006619
NP_001136127; NP_067523; NP_001344807; NP_001344808; NP_001344809;
	NP_001344810
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

cAMP-regulirani fosfoprotein 19 je protein koji je kod ljudi kodiran genom ARPP19.^[5]^[6]^[7]

Aminokiselinska sekvenca

Simboli

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128989 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007656 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dulubova I, Horiuchi A, Snyder GL, Girault JA, Czernik AJ, Shao L, Ramabhadran R, Greengard P, Nairn AC (2001). "ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins". J. Neurochem. 77 (1): 229–38. doi:10.1046/j.1471-4159.2001.t01-1-00191.x. PMID 11279279.
^ Peyrollier K, Héron L, Virsolvy-Vergine A, Le Cam A, Bataille D (1996). "Alpha endosulfine is a novel molecule, structurally related to a family of phosphoproteins". Biochem. Biophys. Res. Commun. 223 (3): 583–6. doi:10.1006/bbrc.1996.0938. PMID 8687439.
^ "Entrez Gene: ARPP-19 cyclic AMP phosphoprotein, 19 kD".
^ "UniProt, P56211". Pristupljeno 12. 7. 2021.

Kim SH, Nairn AC, Cairns N, Lubec G (2001). "Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease". J. Neural Transm. Suppl. (61): 263–72. doi:10.1007/978-3-7091-6262-0_21. PMID 11771749.
Chin LS, Singh SK, Wang Q, Murray SF (2000). "Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells". J. Biomed. Sci. 7 (2): 152–9. doi:10.1007/BF02256622. PMID 10754390.
Heron L, Virsolvy A, Peyrollier K, Gribble FM, Le Cam A, Ashcroft FM, Bataille D (1998). "Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8387–91. doi:10.1073/pnas.95.14.8387. PMC 20985. PMID 9653196.
Brené S, Lindefors N, Ehrlich M, Taubes T, Horiuchi A, Kopp J, Hall H, Sedvall G, Greengard P, Persson H (1994). "Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue". J. Neurosci. 14 (3 Pt 1): 985–98. doi:10.1523/JNEUROSCI.14-03-00985.1994. PMC 6577526. PMID 8120638.
Horiuchi A, Williams KR, Kurihara T, Nairn AC, Greengard P (1990). "Purification and cDNA cloning of ARPP-16, a cAMP-regulated phosphoprotein enriched in basal ganglia, and of a related phosphoprotein, ARPP-19". J. Biol. Chem. 265 (16): 9476–84. PMID 2160982.

Lokacija ljudskog genoma ARPP19 i stranica sa detaljima o genu ARPP19 u UCSC Genome Browseru.