CABYR

CABYR
Identifikatori
Aliasi	CABYR
Vanjski ID-jevi	OMIM: 612135 MGI: 1918382 HomoloGene: 49299 GeneCards: CABYR
Lokacija gena (čovjek)
Hrom.	Hromosom 18 (čovjek)
Kraj	24,161,600 bp
Lokacija gena (miš)
Hrom.	Hromosom 18 (miš)
Kraj	12,888,317 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• SH3 domain binding; • vezivanje enzima; • calcium ion binding; • GO:0001948, GO:0016582 vezivanje za proteine; • protein domain specific binding; • vezivanje iona metala; • protein heterodimerization activity;
Ćelijska komponenta	• citoplazma; • sperm principal piece; • projekcija ćelije; • motile cilium; • Treplja; • sperm fibrous sheath; • citoskelet; • jedro; • sperm end piece; • citosol; • extracellular region;
Biološki proces	• sperm capacitation; • epithelial cilium movement involved in extracellular fluid movement;
	Izvori:Amigo / QuickGO
Ortolozi
	26256
	71132
	ENSG00000154040
	ENSMUSG00000024430
	O75952
	Q9D424
NM_001308231; NM_012189; NM_138643; NM_138644; NM_153768;
	NM_153769; NM_153770
	NM_001042418; NM_001042419; NM_001042420; NM_027687; NM_181731
NP_001295160; NP_036321; NP_619584; NP_619585; NP_722452;
	NP_722453; NP_722454; NP_001295160.1
	NP_001035883; NP_001035884; NP_001035885; NP_081963; NP_859420
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Kalcij-vezujući tirozinski protein za regulaciji fosforilacije je protein koji je kod ljudi kodiran genom CABYR.^[5]^[6]^[7]^[8]

Dužina polipeptidnog lanca je 493 aminokiseline, a molekulska masa— 52 774.

Da bi postigli sposobnost oplodnje, spermatozoidi prolaze kroz niz morfoloških i molekulskih procesa sazrijevanja, zvanih kapacitacija, koji uključuju fosforilaciju tirozinskih proteina i povećani unutarćelijski kalcij. Protein koji kodira ovaj gen lokaliziran je na glavnom komadu biča spermatozoida, zajedno sa vlaknastom ovojnicom, sa vezanjem kalcija kada se fosforilizita tokom kapacitacije. Za ovaj gen je identifikovan pseudogen na hromosomu 3. Varijante transkripta ovog gena kodiraju višestruke proteinske izoforme. Dodatni transkript i izoforme nisu u potpunosti okarakterizirani.^[8]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MISSKPRLVV	PYGLKTLLEG	ISRAVLKTNP	SNINQFAAAY	FQELTMYRGN
TTMDIKDLVK	QFHQIKVEKW	SEGTTPQKKL	ECLKEPGKTS	VESKVPTQME
KSTDTDEDNV	TRTEYSDKTT	QFPSVYAVPG	TEQTEAVGGL	SSKPATPKTT
TPPSSPPPTA	VSPEFAYVPA	DPAQLAAQML	GKVSSIHSDQ	SDVLMVDVAT
SMPVVIKEVP	SSEAAEDVMV	AAPLVCSGKV	LEVQVVNQTS	VHVDLGSQPK
ENEAEPSTAS	SVPLQDEQEP	PAYDQAPEVT	LQADIEVMST	VHISSVYNDV
PVTEGVVYIE	QLPEQIVIPF	TDQVACLKEN	EQSKENEQSP	RVSPKSVVEK
TTSGMSKKSV	ESVKLAQLEE	NAKYSSVYME	AEATALLSDT	SLKGQPEVPA
QLLDAEGAIK	IGSEKSLHLE	VEITSIVSDN	TGQEESGENS	VPQEMEGKPV
LSGEAAEAVH	SGTSVKSSSG	PFPPAPEGLT	APEIEPEGES	TAE

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154040 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024430 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Naaby-Hansen S, Mandal A, Wolkowicz MJ, Sen B, Westbrook VA, Shetty J, Coonrod SA, Klotz KL, Kim YH, Bush LA, Flickinger CJ, Herr JC (Jan 2002). "CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation". Dev Biol. 242 (2): 236–54. doi:10.1006/dbio.2001.0527. PMID 11820818.
^ Luo C, Xiao X, Liu D, Chen S, Li M, Xu A, Liu J, Gao S, Wu S, He D (Feb 2007). "CABYR is a novel cancer-testis antigen in lung cancer". Clin Cancer Res. 13 (4): 1288–97. doi:10.1158/1078-0432.CCR-06-1742. PMID 17317841.
^ Kim YH, Jha KN, Mandal A, Vanage G, Farris E, Snow PL, Klotz K, Naaby-Hansen S, Flickinger CJ, Herr JC (Oct 2005). "Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A". Dev Biol. 286 (1): 46–56. doi:10.1016/j.ydbio.2005.07.005. PMID 16139264.
^ ^a ^b "Entrez Gene: CABYR calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)".

Vanjski linkovi

Lokacija ljudskog genoma CABYR i stranica sa detaljima o genu CABYR u UCSC Genome Browseru.

Dopunska literatura

Fouquet JP; Kann ML (1995). "The cytoskeleton of mammalian spermatozoa". Biol. Cell. 81 (2): 89–93. doi:10.1016/S0248-4900(94)80001-4. PMID 7849610. S2CID 39352537.
Visconti PE, Westbrook VA, Chertihin O, et al. (2002). "Novel signaling pathways involved in sperm acquisition of fertilizing capacity". J. Reprod. Immunol. 53 (1–2): 133–50. doi:10.1016/S0165-0378(01)00103-6. PMID 11730911.
Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ficarro S, Chertihin O, Westbrook VA, et al. (2003). "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation". J. Biol. Chem. 278 (13): 11579–89. doi:10.1074/jbc.M202325200. PMID 12509440.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hsu HC, Lee YL, Cheng TS, et al. (2005). "Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain". Biochem. Biophys. Res. Commun. 329 (3): 1108–17. doi:10.1016/j.bbrc.2005.02.089. PMID 15752768.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154040 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024430 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11820818-5] Naaby-Hansen S, Mandal A, Wolkowicz MJ, Sen B, Westbrook VA, Shetty J, Coonrod SA, Klotz KL, Kim YH, Bush LA, Flickinger CJ, Herr JC (Jan 2002). "CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation". Dev Biol. 242 (2): 236–54. doi:10.1006/dbio.2001.0527. PMID 11820818.

[pmid17317841-6] Luo C, Xiao X, Liu D, Chen S, Li M, Xu A, Liu J, Gao S, Wu S, He D (Feb 2007). "CABYR is a novel cancer-testis antigen in lung cancer". Clin Cancer Res. 13 (4): 1288–97. doi:10.1158/1078-0432.CCR-06-1742. PMID 17317841.

[pmid16139264-7] Kim YH, Jha KN, Mandal A, Vanage G, Farris E, Snow PL, Klotz K, Naaby-Hansen S, Flickinger CJ, Herr JC (Oct 2005). "Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A". Dev Biol. 286 (1): 46–56. doi:10.1016/j.ydbio.2005.07.005. PMID 16139264.

[entrez-8] "Entrez Gene: CABYR calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)".

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