C8orf4

C8orf4
Identifikatori
Aliasi	TCIM
Vanjski ID-jevi	OMIM: 607702 MGI: 1916318 HomoloGene: 10590 GeneCards: TCIM
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	40,155,310 bp
Lokacija gena (miš)
Hrom.	Hromosom 8 (miš)
Kraj	24,929,000 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • Notch binding;
Ćelijska komponenta	• citoplazma; • nuclear speck; • Jedarce; • jedro; • nukleoplazma; • citosol; • ćelijska membrana; • intracellular anatomical structure;
Biološki proces	• regulation of cell cycle G1/S phase transition; • endothelial cell activation involved in immune response; • cellular response to heat; • regulation of DNA-templated transcription in response to stress; • regulation of hemopoiesis; • negative regulation of Notch signaling pathway; • GO:0097285 apoptoza; • positive regulation of protein kinase A signaling; • negative regulation of apoptotic process; • positive regulation of protein kinase C activity; • positive regulation of NIK/NF-kappaB signaling;
	Izvori:Amigo / QuickGO
Ortolozi
	56892
	69068
	ENSG00000176907
	ENSMUSG00000056313
	Q9NR00
	Q9D915
	NM_020130
	NM_026931
	NP_064515
	NP_081207
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

TCIM je protein koji je kod ljudi kodiran genom TCIM.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 106 aminokiselina, а molekulska težina 12.337 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKAKRSHQAV	IMSTSLRVSP	SIHGYHFDTA	SRKKAVGNIF	ENTDQESLER
LFRNSGDKKA	EERAKIIFAI	DQDVEEKTRA	LMALKKRTKD	KLFQFLKLRK
YSIKVH

Funkcija

Ovaj gen kodira mali, monomerni, pretežno nestrukturirani protein (106 aminokiselina, 12,3 kDa, izoelektrična tačka 9,39).^[8] To je pozitivni regulator signalnog puta Wnt / beta-katenina. Ovaj protein stupa u interakciju s represorom beta-katenin posredovane transkripcije na jedarnim pjegama. Smatra se da konkurentno blokira interakcije represora s beta-kateninom, što rezultira povećanom regulacijom beta-kateninskih ciljnih gena.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176907 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056313 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chua EL, Young L, Wu WM, Turtle JR, Dong Q (novembar 2000). "Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer". Genomics. 69 (3): 342–7. doi:10.1006/geno.2000.6348. PMID 11056052.
^ ^a ^b "Entrez Gene: C8orf4 chromosome 8 open reading frame 4".
^ "UniProt, Q9NR00". Pristupljeno 14. 9. 2021.
^ Kozlowski LP (oktobar 2016). "IPC - Isoelectric Point Calculator". Biology Direct. 11 (1): 55. doi:10.1186/s13062-016-0159-9. PMC 5075173. PMID 27769290. Arhivirano s originala, 29. 4. 2013. Pristupljeno 22. 9. 2021.

Dopunska literatura

Bonaldo MF, Lennon G, Soares MB (septembar 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Sunde M, McGrath KC, Young L, Matthews JM, Chua EL, Mackay JP, Death AK (april 2004). "TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer". Cancer Research. 64 (8): 2766–73. doi:10.1158/0008-5472.CAN-03-2093. PMID 15087392.
Friedman JB, Brunschwig EB, Platzer P, Wilson K, Markowitz SD (august 2004). "C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer". International Journal of Cancer. 111 (1): 72–5. doi:10.1002/ijc.20235. PMID 15185345. S2CID 19983783.
Jung Y, Bang S, Choi K, Kim E, Kim Y, Kim J, Park J, Koo H, Moon RT, Song K, Lee I (januar 2006). "TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby". Cancer Research. 66 (2): 723–8. doi:10.1158/0008-5472.CAN-05-3124. PMID 16424001.
Kim B, Koo H, Yang S, Bang S, Jung Y, Kim Y, Kim J, Park J, Moon RT, Song K, Lee I (juni 2006). "TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer". Clinical Cancer Research. 12 (11 Pt 1): 3541–8. doi:10.1158/1078-0432.CCR-05-2440. PMID 16740781.
Yang ZQ, Streicher KL, Ray ME, Abrams J, Ethier SP (decembar 2006). "Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer". Cancer Research. 66 (24): 11632–43. doi:10.1158/0008-5472.CAN-06-2946. PMID 17178857.
Yang ZQ, Moffa AB, Haddad R, Streicher KL, Ethier SP (septembar 2007). "Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways". International Journal of Cancer. 121 (6): 1265–73. doi:10.1002/ijc.22831. PMID 17520678. S2CID 25292320.
Park J, Jung Y, Kim J, Kim KY, Ahn SG, Song K, Lee I (august 2007). "TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response". Biochemical and Biophysical Research Communications. 360 (2): 447–52. doi:10.1016/j.bbrc.2007.06.077. PMID 17603013.

Vanjski linkovi

Lokacija ljudskog genoma C8orf4 i stranica sa detaljima o genu C8orf4 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176907 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056313 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11056052-5] Chua EL, Young L, Wu WM, Turtle JR, Dong Q (novembar 2000). "Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer". Genomics. 69 (3): 342–7. doi:10.1006/geno.2000.6348. PMID 11056052.

[entrez-6] "Entrez Gene: C8orf4 chromosome 8 open reading frame 4".

[UniProt-7] "UniProt, Q9NR00". Pristupljeno 14. 9. 2021.

[Kozlowski-8] Kozlowski LP (oktobar 2016). "IPC - Isoelectric Point Calculator". Biology Direct. 11 (1): 55. doi:10.1186/s13062-016-0159-9. PMC 5075173. PMID 27769290. Arhivirano s originala, 29. 4. 2013. Pristupljeno 22. 9. 2021.

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