C1QTNF4

Protein 4 srodan C1q i tumorskom faktoru nekroze je protein koji je kod ljudi kodiran genom C1QTNF4.

C1QTNF4
Identifikatori
Aliasi	C1QTNF4
Vanjski ID-jevi	OMIM: 614911 MGI: 1914695 HomoloGene: 12134 GeneCards: C1QTNF4
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek) Bend 11p11.2 Početak 47,589,667 bp Kraj 47,594,411 bp
Lokacija gena (miš) Hrom. Hromosom 2 (miš) Bend 2|2 E1 Početak 90,716,204 bp Kraj 90,720,869 bp
Ontologija gena Molekularna funkcija • cytokine activity • molekularna funkcija Ćelijska komponenta • extracellular region • Vanćelijsko Biološki proces • regulation of signaling receptor activity • positive regulation of interleukin-6 production • positive regulation of interleukin-6-mediated signaling pathway • positive regulation of NIK/NF-kappaB signaling • GO:0072468 Transdukcija signala Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	114900	67445
Ensembl	ENSG00000172247 ENSG00000284838	ENSMUSG00000040794
UniProt	Q9BXJ3	Q8R066
RefSeq (mRNK)	NM_031909	NM_026161
RefSeq (bjelančevina)	NP_114115	NP_080437
Lokacija (UCSC)	Chr 11: 47.59 – 47.59 Mb	Chr 2: 90.72 – 90.72 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 329 aminokiselina, a molekulska težina 35.256 Da..

10		20		30		40		50
MLPLLLGLLG		PAACWALGPT		PGPGSSELRS		AFSAARTTPL		EGTSEMAVTF
DKVYVNIGGD		FDVATGQFRC		RVPGAYFFSF		TAGKAPHKSL		SVMLVRNRDE
VQALAFDEQR		RPGARRAASQ		SAMLQLDYGD		TVWLRLHGAP		QYALGAPGAT
FSGYLVYADA		DADAPARGPP		APPEPRSAFS		AARTRSLVGS		DAGPGPRHQP
LAFDTEFVNI		GGDFDAAAGV		FRCRLPGAYF		FSFTLGKLPR		KTLSVKLMKN
RDEVQAMIYD		DGASRRREMQ		SQSVMLALRR		GDAVWLLSHD		HDGYGAYSNH
GKYITFSGFL		VYPDLAPAAP		PGLGASELL

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

Dopunska literatura

• Li Q, Wang L, Tan W, Peng Z, Luo Y, Zhang Y, Zhang G, Na D, Jin P, Shi T, Ma D, Wang L (2011). "Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-κB pathways and promotes cell survival in human cancer cells". Cancer Lett. 308 (2): 203–14. doi:10.1016/j.canlet.2011.05.005. PMID 21658842.