AZIN1

AZIN1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4ZGZ
Identifikatori
Aliasi	AZIN1
Vanjski ID-jevi	OMIM: 607909 MGI: 1859169 HomoloGene: 22933 GeneCards: AZIN1
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	102,893,864 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	38,519,510 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• ornithine decarboxylase activator activity; • GO:0001948, GO:0016582 vezivanje za proteine; • catalytic activity; • ornithine decarboxylase activity;
Ćelijska komponenta	• citosol; • jedro; • citoplazma;
Biološki proces	• polyamine biosynthetic process; • positive regulation of polyamine transmembrane transport; • regulation of cellular amino acid metabolic process; • putrescine biosynthetic process from ornithine; • GO:0048554 positive regulation of catalytic activity; • GO:1903363 negative regulation of protein catabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	51582
	54375
	ENSG00000155096
	ENSMUSG00000037458
	O14977
	O35484
NM_001301668; NM_015878; NM_148174; NM_001363010; NM_001363011;
	NM_001363012; NM_001363013; NM_001363014; NM_001363024; NM_001363083
	NM_001102458; NM_001301688; NM_018745
NP_001288597; NP_056962; NP_680479; NP_001349939; NP_001349940;
	NP_001349941; NP_001349942; NP_001349943; NP_001349953; NP_001350012
	NP_001095928; NP_001288617; NP_061215
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Antizimski inhibitor 1 je protein koji je kod ljudi kodiran genom AZIN1.^[5]^[6]^[7]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 448 aminokiselina, а molekulska težina 49.535 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKGFIDDANY	SVGLLDEGTN	LGNVIDNYVY	EHTLTGKNAF	FVGDLGKIVK
KHSQWQNVVA	QIKPFYTVKC	NSAPAVLEIL	AALGTGFACS	SKNEMALVQE
LGVPPENIIY	ISPCKQVSQI	KYAAKVGVNI	LTCDNEIELK	KIARNHPNAK
VLLHIATEDN	IGGEEGNMKF	GTTLKNCRHL	LECAKELDVQ	IIGVKFHVSS
ACKESQVYVH	ALSDARCVFD	MAGEIGFTMN	MLDIGGGFTG	TEFQLEEVNH
VISPLLDIYF	PEGSGVKIIS	EPGSYYVSSA	FTLAVNIIAK	KVVENDKFPS
GVEKTGSDEP	AFMYYMNDGV	YGSFASKLSE	DLNTIPEVHK	KYKEDEPLFT
SSLWGPSCDE	LDQIVESCLL	PELNVGDWLI	FDNMGADSFH	EPSAFNDFQR
PAIYYMMSFS	DWYEMQDAGI	TSDSMMKNFF	FVPSCIQLSQ	EDSFSAEA

Funkcija uredi

Ornitin-dekarboksilaza (ODC) katalizira pretvaranje ornitina u putrescin u prvom i očiglednom koraku ograničavanja brzine u biosintezi poliamina. Antizim ornitin-dekarboksilaza ima ulogu u regulaciji sinteze poliamina, vezivanjem i inhibiranjem ornitin-dekarboksilaze. Protein kodiran ovim genom vrlo je sličan ODC-u. Veže se na ODC antizim i stabilizira ODC, čime se inhibira razgradnja ODC-a posredovana pomoću enzima. Za ovaj gen su pronađene dvije alternativno prerađene varijante transkripta.^[7]

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155096 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037458 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Koguchi K, Kobayashi S, Hayashi T, Matsufuji S, Murakami Y, Hayashi S (Nov 1997). "Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor". Biochim Biophys Acta. 1353 (3): 209–16. doi:10.1016/s0167-4781(97)00106-1. PMID 9349715.
^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
^ ^a ^b "Entrez Gene: AZIN1 antizyme inhibitor 1".
^ "UniProt, O14977". Pristupljeno 14. 9. 2021.

Dopunska literatura uredi

Murakami Y, Matsufuji S, Hayashi S, et al. (2000). "Degradation of ornithine decarboxylase by the 26S proteasome". Biochem. Biophys. Res. Commun. 267 (1): 1–6. doi:10.1006/bbrc.1999.1706. PMID 10623564.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Vanjski linkovi uredi

Lokacija ljudskog genoma AZIN1 i stranica sa detaljima o genu AZIN1 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155096 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037458 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9349715-5] Koguchi K, Kobayashi S, Hayashi T, Matsufuji S, Murakami Y, Hayashi S (Nov 1997). "Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor". Biochim Biophys Acta. 1353 (3): 209–16. doi:10.1016/s0167-4781(97)00106-1. PMID 9349715.

[pmid9110174-6] Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.

[entrez-7] "Entrez Gene: AZIN1 antizyme inhibitor 1".

[UniProt-8] "UniProt, O14977". Pristupljeno 14. 9. 2021.

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