APLNR

APLNR
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2LOT, 2LOU, 2LOV, 2LOW
Identifikatori
Aliasi	APLNR
Vanjski ID-jevi	OMIM: 600052 MGI: 1346086 HomoloGene: 3784 GeneCards: APLNR
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	57,237,250 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	84,970,267 bp
Ontologija gena
Molekularna funkcija	• G protein-coupled receptor activity; • signal transducer activity; • signaling receptor activity; • apelin receptor activity;
Ćelijska komponenta	• integral component of membrane; • integral component of plasma membrane; • membrana; • ćelijska membrana;
Biološki proces	• multicellular organism development; • heart development; • regulation of body fluid levels; • Gastrulacija; • GO:0072468 Transdukcija signala; • G protein-coupled receptor signaling pathway; • negative regulation of cAMP-mediated signaling; • positive regulation of angiogenesis; • positive regulation of release of sequestered calcium ion into cytosol; • positive regulation of inhibitory G protein-coupled receptor phosphorylation; • Vaskulogeneza; • adult heart development; • coronary vasculature development; • positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; • Angiogeneza; • blood vessel development; • apelin receptor signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	187
	23796
	ENSG00000134817
	ENSMUSG00000044338
	P35414
	Q9WV08
	NM_005161
	NM_011784
	NP_005152
	NP_035914
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Apelinski receptor (APLNR, znan i kao APJ) je G-protein spregnuti receptor.^[5] APLNR ima dva endogena liganda koji su APELIN^[6]^[7]^[8] i ELABELA.^[9]^[10] Struktura APLNR riješena je 2017.^[11]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 380 aminokiselina, a molekulska težina 4.660 Da.^[12].

10	20	30	40	50
MEEGGDFDNY	YGADNQSECE	YTDWKSSGAL	IPAIYMLVFL	LGTTGNGLVL
WTVFRSSREK	RRSADIFIAS	LAVADLTFVV	TLPLWATYTY	RDYDWPFGTF
FCKLSSYLIF	VNMYASVFCL	TGLSFDRYLA	IVRPVANARL	RLRVSGAVAT
AVLWVLAALL	AMPVMVLRTT	GDLENTTKVQ	CYMDYSMVAT	VSSEWAWEVG
LGVSSTTVGF	VVPFTIMLTC	YFFIAQTIAG	HFRKERIEGL	RKRRRLLSII
VVLVVTFALC	WMPYHLVKTL	YMLGSLLHWP	CDFDLFLMNI	FPYCTCISYV
NSCLNPFLYA	FFDPRFRQAC	TSMLCCGQSR	CAGTSHSSSG	EKSASYSSGH
SQGPGPNMGK	GGEQMHEKSI	PYSQETLVVD

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134817 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044338 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ O'Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL, et al. (decembar 1993). "A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11". Gene. 136 (1–2): 355–60. doi:10.1016/0378-1119(93)90495-O. PMID 8294032.
^ Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, et al. (oktobar 1998). "Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor". Biochemical and Biophysical Research Communications. 251 (2): 471–6. doi:10.1006/bbrc.1998.9489. PMID 9792798.
^ Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, et al. (januar 2000). "Characterization of apelin, the ligand for the APJ receptor". Journal of Neurochemistry. 74 (1): 34–41. doi:10.1046/j.1471-4159.2000.0740034.x. PMID 10617103. S2CID 6548112.
^ Szokodi I, Tavi P, Földes G, Voutilainen-Myllylä S, Ilves M, Tokola H, et al. (septembar 2002). "Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility". Circulation Research. 91 (5): 434–40. doi:10.1161/01.RES.0000033522.37861.69. PMID 12215493.
^ Chng SC, Ho L, Tian J, Reversade B (decembar 2013). "ELABELA: a hormone essential for heart development signals via the apelin receptor". Developmental Cell. 27 (6): 672–80. doi:10.1016/j.devcel.2013.11.002. PMID 24316148.
^ Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, et al. (februar 2014). "Toddler: an embryonic signal that promotes cell movement via Apelin receptors". Science. 343 (6172): 1248636. doi:10.1126/science.1248636. PMC 4107353. PMID 24407481.
^ Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, et al. (juni 2017). "Structural Basis for Apelin Control of the Human Apelin Receptor". Structure. 25 (6): 858–866.e4. doi:10.1016/j.str.2017.04.008. PMID 28528775.
^ "UniProt, P35414". Pristupljeno 16. 8. 2021.

Dopunska literatura

Hinohara K, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban JM, et al. (septembar 2009). "Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations". Journal of Human Genetics. 54 (9): 554–6. doi:10.1038/jhg.2009.78. PMID 19680269.
Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushita T, Ohnishi Y, et al. (mart 2007). "Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction". Human Molecular Genetics. 16 (6): 630–9. doi:10.1093/hmg/ddm005. PMID 17309882.
Kälin RE, Kretz MP, Meyer AM, Kispert A, Heppner FL, Brändli AW (maj 2007). "Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis". Developmental Biology. 305 (2): 599–614. doi:10.1016/j.ydbio.2007.03.004. PMID 17412318.
Zhou N, Zhang X, Fan X, Argyris E, Fang J, Acheampong E, et al. (decembar 2003). "The N-terminal domain of APJ, a CNS-based coreceptor for HIV-1, is essential for its receptor function and coreceptor activity". Virology. 317 (1): 84–94. doi:10.1016/j.virol.2003.08.026. PMID 14675627.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2005). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
O'Carroll AM, Don AL, Lolait SJ (novembar 2003). "APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids". Journal of Neuroendocrinology. 15 (11): 1095–101. doi:10.1046/j.1365-2826.2003.01102.x. PMID 14622440. S2CID 23108475.
Sarzani R, Forleo C, Pietrucci F, Capestro A, Soura E, Guida P, et al. (septembar 2007). "The 212A variant of the APJ receptor gene for the endogenous inotrope apelin is associated with slower heart failure progression in idiopathic dilated cardiomyopathy". Journal of Cardiac Failure. 13 (7): 521–9. doi:10.1016/j.cardfail.2007.04.002. PMID 17826642.
Langelaan DN, Bebbington EM, Reddy T, Rainey JK (januar 2009). "Structural insight into G-protein coupled receptor binding by apelin". Biochemistry. 48 (3): 537–48. doi:10.1021/bi801864b. PMID 19123778.
Zhou N, Fan X, Mukhtar M, Fang J, Patel CA, DuBois GC, Pomerantz RJ (mart 2003). "Cell-cell fusion and internalization of the CNS-based, HIV-1 co-receptor, APJ". Virology. 307 (1): 22–36. doi:10.1016/S0042-6822(02)00021-1. PMID 12667811.
Li WW, Niu WQ, Zhang Y, Wu S, Gao PJ, Zhu DL (juni 2009). "Family-based analysis of apelin and AGTRL1 gene polymorphisms with hypertension in Han Chinese". Journal of Hypertension. 27 (6): 1194–201. doi:10.1097/HJH.0b013e32832a3eb1. PMID 19307984. S2CID 12333756.
Lee DK, Lança AJ, Cheng R, Nguyen T, Ji XD, Gobeil F, et al. (februar 2004). "Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors". The Journal of Biological Chemistry. 279 (9): 7901–8. doi:10.1074/jbc.M306377200. PMID 14645236.
Choe H, Martin KA, Farzan M, Sodroski J, Gerard NP, Gerard C (juni 1998). "Structural interactions between chemokine receptors, gp120 Env and CD4". Seminars in Immunology. 10 (3): 249–57. doi:10.1006/smim.1998.0127. PMID 9653051.
Kleinz MJ, Skepper JN, Davenport AP (mart 2005). "Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells". Regulatory Peptides. 126 (3): 233–40. doi:10.1016/j.regpep.2004.10.019. PMID 15664671. S2CID 24947092.
Luttrell LM (juli 2008). "Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors". Molecular Biotechnology. 39 (3): 239–64. doi:10.1007/s12033-008-9031-1. PMID 18240029. S2CID 45173229.
Cobellis L, De Falco M, Mastrogiacomo A, Giraldi D, Dattilo D, Scaffa C, et al. (januar 2007). "Modulation of apelin and APJ receptor in normal and preeclampsia-complicated placentas". Histology and Histopathology. 22 (1): 1–8. doi:10.14670/HH-22.1. PMID 17128405.
Kubo M (novembar 2008). "[Genetic risk factors of ischemic stroke identified by a genome-wide association study]". Brain and Nerve = Shinkei Kenkyu No Shinpo. 60 (11): 1339–46. PMID 19069168.
Bai B, Tang J, Liu H, Chen J, Li Y, Song W (april 2008). "Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway". Acta Biochimica et Biophysica Sinica. 40 (4): 311–8. doi:10.1111/j.1745-7270.2008.00403.x. PMID 18401529.
Ishida J, Hashimoto T, Hashimoto Y, Nishiwaki S, Iguchi T, Harada S, et al. (juni 2004). "Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo". The Journal of Biological Chemistry. 279 (25): 26274–9. doi:10.1074/jbc.M404149200. PMID 15087458.

Vanjski linkovi

"Apelin Receptor: APJ". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano s originala, 16. 8. 2021. Pristupljeno 16. 8. 2021.
Apelin receptor, human na US National Library of Medicine Medical Subject Headings (MeSH)
Lokacija ljudskog genoma APLNR i stranica sa detaljima o genu APLNR u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134817 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044338 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8294032-5] O'Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL, et al. (decembar 1993). "A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11". Gene. 136 (1–2): 355–60. doi:10.1016/0378-1119(93)90495-O. PMID 8294032.

[pmid9792798-6] Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, et al. (oktobar 1998). "Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor". Biochemical and Biophysical Research Communications. 251 (2): 471–6. doi:10.1006/bbrc.1998.9489. PMID 9792798.

[pmid10617103-7] Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, et al. (januar 2000). "Characterization of apelin, the ligand for the APJ receptor". Journal of Neurochemistry. 74 (1): 34–41. doi:10.1046/j.1471-4159.2000.0740034.x. PMID 10617103. S2CID 6548112.

[pmid12215493-8] Szokodi I, Tavi P, Földes G, Voutilainen-Myllylä S, Ilves M, Tokola H, et al. (septembar 2002). "Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility". Circulation Research. 91 (5): 434–40. doi:10.1161/01.RES.0000033522.37861.69. PMID 12215493.

[pmid24316148-9] Chng SC, Ho L, Tian J, Reversade B (decembar 2013). "ELABELA: a hormone essential for heart development signals via the apelin receptor". Developmental Cell. 27 (6): 672–80. doi:10.1016/j.devcel.2013.11.002. PMID 24316148.

[pmid24407481-10] Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, et al. (februar 2014). "Toddler: an embryonic signal that promotes cell movement via Apelin receptors". Science. 343 (6172): 1248636. doi:10.1126/science.1248636. PMC 4107353. PMID 24407481.

[11] Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, et al. (juni 2017). "Structural Basis for Apelin Control of the Human Apelin Receptor". Structure. 25 (6): 858–866.e4. doi:10.1016/j.str.2017.04.008. PMID 28528775.

[UniProt-12] "UniProt, P35414". Pristupljeno 16. 8. 2021.

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