AEBP1

AEBP1
Identifikatori
Aliasi	AEBP1
Vanjski ID-jevi	OMIM: 602981 MGI: 1197012 HomoloGene: 878 GeneCards: AEBP1
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	44,114,562 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	5,822,088 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001106 transcription corepressor activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • vezivanje iona cinka; • calmodulin binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • metallocarboxypeptidase activity; • carboxypeptidase activity; • serine-type carboxypeptidase activity; • extracellular matrix structural constituent; • collagen binding;
Ćelijska komponenta	• citoplazma; • GO:0005578 Vanćelijski matriks; • Egzosom; • jedro; • Vanćelijsko; • extracellular region; • collagen-containing extracellular matrix;
Biološki proces	• skeletal system development; • GO:0009373 regulation of transcription, DNA-templated; • peptide metabolic process; • protein processing; • muscle organ development; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • Proteoliza; • regulation of collagen fibril organization;
	Izvori:Amigo / QuickGO
Ortolozi
	165
	11568
	ENSG00000106624
	ENSMUSG00000020473
	Q8IUX7
	Q640N1
	NM_001129
	NM_001291857; NM_009636
	NP_001120
	NP_001278786; NP_033766
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

AE-vezujući protein 1 je protein koji je kod ljudi kodiran genom AEBP1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.158 aminokiselina, а molekulska težina 130.929 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAAVRGAPLL	SCLLALLALC	PGGRPQTVLT	DDEIEEFLEG	FLSELEPEPR
EDDVEAPPPP	EPTPRVRKAQ	AGGKPGKRPG	TAAEVPPEKT	KDKGKKGKKD
KGPKVPKESL	EGSPRPPKKG	KEKPPKATKK	PKEKPPKATK	KPKEKPPKAT
KKPKEKPPKA	TKKPPSGKRP	PILAPSETLE	WPLPPPPSPG	PEELPQEGGA
PLSNNWQNPG	EETHVEAREH	QPEPEEETEQ	PTLDYNDQIE	REDYEDFEYI
RRQKQPRPPP	SRRRRPERVW	PEPPEEKAPA	PAPEERIEPP	VKPLLPPLPP
DYGDGYVIPN	YDDMDYYFGP	PPPQKPDAER	QTDEEKEELK	KPKKEDSSPK
EETDKWAVEK	GKDHKEPRKG	EELEEEWTPT	EKVKCPPIGM	ESHRIEDNQI
RASSMLRHGL	GAQRGRLNMQ	TGATEDDYYD	GAWCAEDDAR	TQWIEVDTRR
TTRFTGVITQ	GRDSSIHDDF	VTTFFVGFSN	DSQTWVMYTN	GYEEMTFHGN
VDKDTPVLSE	LPEPVVARFI	RIYPLTWNGS	LCMRLEVLGC	SVAPVYSYYA
QNEVVATDDL	DFRHHSYKDM	RQLMKVVNEE	CPTITRTYSL	GKSSRGLKIY
AMEISDNPGE	HELGEPEFRY	TAGIHGNEVL	GRELLLLLMQ	YLCREYRDGN
PRVRSLVQDT	RIHLVPSLNP	DGYEVAAQMG	SEFGNWALGL	WTEEGFDIFE
DFPDLNSVLW	GAEERKWVPY	RVPNNNLPIP	ERYLSPDATV	STEVRAIIAW
MEKNPFVLGA	NLNGGERLVS	YPYDMARTPT	QEQLLAAAMA	AARGEDEDEV
SEAQETPDHA	IFRWLAISFA	SAHLTLTEPY	RGGCQAQDYT	GGMGIVNGAK
WNPRTGTIND	FSYLHTNCLE	LSFYLGCDKF	PHESELPREW	ENNKEALLTF
MEQVHRGIKG	VVTDEQGIPI	ANATISVSGI	NHGVKTASGG	DYWRILNPGE
YRVTAHAEGY	TPSAKTCNVD	YDIGATQCNF	ILARSNWKRI	REIMAMNGNR
PIPHIDPSRP	MTPQQRRLQQ	RRLQHRLRLR	AQMRLRRLNA	TTTLGPHTVP
PTLPPAPATT	LSTTIEPWGL	IPPTTAGWEE	SETETYTEVV	TEFGTEVEPE
FGTKVEPEFE	TQLEPEFETQ	LEPEFEEEEE	EEKEEEIATG	QAFPFTTVET
YTVNFGDF

Funkcija

AE-vezujući protein 1 je član proteinske porodice karboksipeptidaza A. Protein može funkcionirati kao transkripcijski represor i imati ulogu u adipogenezi i diferencijaciji ćelija u glatkim mišićima. Studije na miševima sugeriraju da gen AEBP1 koji kodira proteinske funkcije u zacjeljivanju rana i razvoju trbušnog zida. Prekomjerna ekspresija ovog gena povezana je s glioblastomomom.^[5]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106624 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020473 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: AE binding protein 1".
^ "UniProt, Q8IUX7" (jezik: engleski). Pristupljeno 22. 9. 2021.

Dopunska literatura

Tumelty KE, Smith BD, Nugent MA, Layne MD (2014). "Aortic carboxypeptidase-like protein (ACLP) enhances lung myofibroblast differentiation through transforming growth factor β receptor-dependent and -independent pathways". Journal of Biological Chemistry. 289 (5): 2526–36. doi:10.1074/jbc.M113.502617. PMC 3908388. PMID 24344132.
Lyons PJ, Muise AM, Ro HS (2005). "MAPK modulates the DNA binding of adipocyte enhancer-binding protein 1". Biochemistry. 44 (3): 926–31. doi:10.1021/bi0480178. PMID 15654748.
Majdalawieh A, Ro HS (2010). "PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1". Nuclear Receptor Signaling. 8: e004. doi:10.1621/nrs.08004. PMC 2858268. PMID 20419060.
Muise AM, Ro HS (1999). "Enzymic characterization of a novel member of the regulatory B-like carboxypeptidase with transcriptional repression function: Stimulation of enzymic activity by its target DNA". The Biochemical Journal. 343 (2): 341–5. doi:10.1042/0264-6021:3430341. PMC 1220559. PMID 10510298.
Feldkamp ML, Bowles NE, Botto LD (2012). "AEBP1 gene variants in infants with gastroschisis". Birth Defects Research Part A: Clinical and Molecular Teratology. 94 (9): 738–42. doi:10.1002/bdra.23041. PMID 22821744.
Layne MD, Yet SF, Maemura K, Hsieh CM, Bernfield M, Perrella MA, Lee ME (2001). "Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein". Molecular and Cellular Biology. 21 (15): 5256–61. doi:10.1128/MCB.21.15.5256-5261.2001. PMC 87249. PMID 11438679.
Ohno I, Hashimoto J, Shimizu K, Takaoka K, Ochi T, Matsubara K, Okubo K (1996). "A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line". Biochemical and Biophysical Research Communications. 228 (2): 411–4. doi:10.1006/bbrc.1996.1675. PMID 8920928.
Majdalawieh A, Ro HS (2010). "Regulation of Ikappa Balpha function and NF-kappaB signaling: AEBP1 is a novel proinflammatory mediator in macrophages". Mediators of Inflammation. 2010: 823821. doi:10.1155/2010/823821. PMC 2855089. PMID 20396415.
Song L, Fricker LD (1997). "Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase". The Journal of Biological Chemistry. 272 (16): 10543–50. doi:10.1074/jbc.272.16.10543. PMID 9099699.

Vanjski linkovi

Lokacija ljudskog genoma AEBP1 i stranica sa detaljima o genu AEBP1 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106624 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020473 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: AE binding protein 1".

[UniProt-6] "UniProt, Q8IUX7" (jezik: engleski). Pristupljeno 22. 9. 2021.

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