ACIN1

Apoptotski induktor hromatinskr kondenzavije u jedru je protein koji je kod ljudi kodiran genom that ACIN1.

ACIN1
Identifikatori
Aliasi	ACIN1
Vanjski ID-jevi	OMIM: 604562 MGI: 1891824 HomoloGene: 22853 GeneCards: ACIN1
Lokacija gena (čovjek) Hrom. Hromosom 14 (čovjek) Bend 14q11.2 Početak 23,058,564 bp Kraj 23,095,614 bp
Lokacija gena (miš) Hrom. Hromosom 14 (miš) Bend 14|14 C2 Početak 54,642,161 bp Kraj 54,686,931 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • ATPase activity • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje enzima • nucleic acid binding • vezivanje sa RNK Ćelijska komponenta • nuclear speck • ćelijska membrana • exon-exon junction complex • nukleoplazma • Jedarce • ASAP complex • jedro • citosol Biološki proces • apoptotic chromosome condensation • mRNA processing • negative regulation of mRNA splicing, via spliceosome • Prerada RNK • positive regulation of apoptotic process • positive regulation of monocyte differentiation • erythrocyte differentiation • GO:0097285 apoptoza • execution phase of apoptosis Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	22985	56215
Ensembl	ENSG00000100813	ENSMUSG00000022185
UniProt	Q9UKV3	Q9JIX8
RefSeq (mRNK)	NM_001164814 NM_001164815 NM_001164816 NM_001164817 NM_014977 NM_001386863	NM_001085472 NM_001085473 NM_001242605 NM_001242606 NM_019567 NM_023190
RefSeq (bjelančevina)	NP_001158286 NP_001158287 NP_001158288 NP_001158289 NP_055792	NP_001078941 NP_001078942 NP_001229534 NP_001229535 NP_062513 NP_075679 NP_001361699
Lokacija (UCSC)	Chr 14: 23.06 – 23.1 Mb	Chr 14: 54.64 – 54.69 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.341 aminokiselina, a molekulska težina 151.862 Da..

10		20		30		40		50
MWRRKHPRTS		GGTRGVLSGN		RGVEYGSGRG		HLGTFEGRWR		KLPKMPEAVG
TDPSTSRKMA		ELEEVTLDGK		PLQALRVTDL		KAALEQRGLA		KSGQKSALVK
RLKGALMLEN		LQKHSTPHAA		FQPNSQIGEE		MSQNSFIKQY		LEKQQELLRQ
RLEREAREAA		ELEEASAESE		DEMIHPEGVA		SLLPPDFQSS		LERPELELSR
HSPRKSSSIS		EEKGDSDDEK		PRKGERRSSR		VRQARAAKLS		EGSQPAEEEE
DQETPSRNLR		VRADRNLKTE		EEEEEEEEEE		EDDEEEEGDD		EGQKSREAPI
LKEFKEEGEE		IPRVKPEEMM		DERPKTRSQE		QEVLERGGRF		TRSQEEARKS
HLARQQQEKE		MKTTSPLEEE		EREIKSSQGL		KEKSKSPSPP		RLTEDRKKAS
LVALPEQTAS		EEETPPPLLT		KEASSPPPHP		QLHSEEEIEP		MEGPAPAVLI
QLSPPNTDAD		TRELLVSQHT		VQLVGGLSPL		SSPSDTKAES		PAEKVPEESV
LPLVQKSTLA		DYSAQKDLEP		ESDRSAQPLP		LKIEELALAK		GITEECLKQP
SLEQKEGRRA		SHTLLPSHRL		KQSADSSSSR		SSSSSSSSSR		SRSRSPDSSG
SRSHSPLRSK		QRDVAQARTH		ANPRGRPKMG		SRSTSESRSR		SRSRSRSASS
NSRKSLSPGV		SRDSSTSYTE		TKDPSSGQEV		ATPPVPQLQV		CEPKERTSTS
SSSVQARRLS		QPESAEKHVT		QRLQPERGSP		KKCEAEEAEP		PAATQPQTSE
TQTSHLPESE		RIHHTVEEKE		EVTMDTSENR		PENDVPEPPM		PIADQVSNDD
RPEGSVEDEE		KKESSLPKSF		KRKISVVSAT		KGVPAGNSDT		EGGQPGRKRR
WGASTATTQK		KPSISITTES		LKSLIPDIKP		LAGQEAVVDL		HADDSRISED
ETERNGDDGT		HDKGLKICRT		VTQVVPAEGQ		ENGQREEEEE		EKEPEAEPPV
PPQVSVEVAL		PPPAEHEVKK		VTLGDTLTRR		SISQQKSGVS		ITIDDPVRTA
QVPSPPRGKI		SNIVHISNLV		RPFTLGQLKE		LLGRTGTLVE		EAFWIDKIKS
HCFVTYSTVE		EAVATRTALH		GVKWPQSNPK		FLCADYAEQD		ELDYHRGLLV
DRPSETKTEE		QGIPRPLHPP		PPPPVQPPQH		PRAEQREQER		AVREQWAERE
REMERRERTR		SEREWDRDKV		REGPRSRSRS		RDRRRKERAK		SKEKKSEKKE
KAQEEPPAKL		LDDLFRKTKA		APCIYWLPLT		DSQIVQKEAE		RAERAKEREK
RRKEQEEEEQ		KEREKEAERE		RNRQLEREKR		REHSRERDRE		RERERERDRG
DRDRDRERDR		ERGRERDRRD		TKRHSRSRSR		STPVRDRGGR		R

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Vanjski linkovi

• Lokacija ljudskog genoma ACIN1 i stranica sa detaljima o genu ACIN1 u UCSC Genome Browseru.

Dopunska literatura

• Zermati Y, Garrido C, Amsellem S, et al. (2001). "Caspase activation is required for terminal erythroid differentiation". J. Exp. Med. 193 (2): 247–54. doi:10.1084/jem.193.2.247. PMC 2193347. PMID 11208865.
• Sordet O, Rébé C, Plenchette S, et al. (2003). "Specific involvement of caspases in the differentiation of monocytes into macrophages". Blood. 100 (13): 4446–53. doi:10.1182/blood-2002-06-1778. PMID 12393560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Mol. Cell. Proteomics. 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Hu Y, Yao J, Liu Z, et al. (2005). "Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation". EMBO J. 24 (20): 3543–54. doi:10.1038/sj.emboj.7600823. PMC 1276706. PMID 16177823.
• Joselin AP, Schulze-Osthoff K, Schwerk C (2006). "Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis". J. Biol. Chem. 281 (18): 12475–84. doi:10.1074/jbc.M509859200. PMID 16537548.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Shu Y, Iijima T, Sun W, et al. (2007). "The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma". Journal of Thoracic Oncology. 1 (2): 160–7. doi:10.1097/01243894-200602000-00010. PMID 17409846.