ZNF236
Cinkoprstni protein 236 je protein koji je kod ljudi kodiran genom ZNF236.[5]
Dužina polipeptidnog lanca je 1.845 aminokiselina, sa molekulskom težinom od 203.704.[6].
Aminokiselinska sekvenca
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MGLCGLLERC | WLHHDPDGVL | TLNAENTNYA | YQVPNFHKCE | ICLLSFPKES | ||||
QFQRHMRDHE | RNDKPHRCDQ | CPQTFNVEFN | LTLHKCTHSG | EDPTCPVCNK | ||||
KFSRVASLKA | HIMLHEKEEN | LICSECGDEF | TLQSQLAVHM | EEHRQELAGT | ||||
RQHACKACKK | EFETSSELKE | HMKTHYKIRV | SSTRSYNRNI | DRSGFTYSCP | ||||
HCGKTFQKPS | QLTRHIRIHT | GERPFKCSEC | GKAFNQKGAL | QTHMIKHTGE | ||||
KPHACAFCPA | AFSQKGNLQS | HVQRVHSEVK | NGPTYNCTEC | SCVFKSLGSL | ||||
NTHISKMHMG | GPQNSTSSTE | TAHVLTATLF | QTLPLQQTEA | QATSASSQPS | ||||
SQAVSDVIQQ | LLELSEPAPV | ESGQSPQPGQ | QLSITVGINQ | DILQQALENS | ||||
GLSSIPAAAH | PNDSCHAKTS | APHAQNPDVS | SVSNEQTDPT | DAEQEKEQES | ||||
PEKLDKKEKK | MIKKKSPFLP | GSIREENGVR | WHVCPYCAKE | FRKPSDLVRH | ||||
IRIHTHEKPF | KCPQCFRAFA | VKSTLTAHIK | THTGIKAFKC | QYCMKSFSTS | ||||
GSLKVHIRLH | TGVRPFACPH | CDKKFRTSGH | RKTHIASHFK | HTELRKMRHQ | ||||
RKPAKVRVGK | TNIPVPDIPL | QEPILITDLG | LIQPIPKNQF | FQSYFNNNFV | ||||
NEADRPYKCF | YCHRAYKKSC | HLKQHIRSHT | GEKPFKCSQC | GRGFVSAGVL | ||||
KAHIRTHTGL | KSFKCLICNG | AFTTGGSLRR | HMGIHNDLRP | YMCPYCQKTF | ||||
KTSLNCKKHM | KTHRYELAQQ | LQQHQQAASI | DDSTVDQQSM | QASTQMQVEI | ||||
ESDELPQTAE | VVAANPEAML | DLEPQHVVGT | EEAGLGQQLA | DQPLEADEDG | ||||
FVAPQDPLRG | HVDQFEEQSP | AQQSFEPAGL | PQGFTVTDTY | HQQPQFPPVQ | ||||
QLQDSSTLES | QALSTSFHQQ | SLLQAPSSDG | MNVTTRLIQE | SSQEELDLQA | ||||
QGSQFLEDNE | DQSRRSYRCD | YCNKGFKKSS | HLKQHVRSHT | GEKPYKCKLC | ||||
GRGFVSSGVL | KSHEKTHTGV | KAFSCSVCNA | SFTTNGSLTR | HMATHMSMKP | ||||
YKCPFCEEGF | RTTVHCKKHM | KRHQTVPSAV | SATGETEGGD | ICMEEEEEHS | ||||
DRNASRKSRP | EVITFTEEET | AQLAKIRPQE | SATVSEKVLV | QSAAEKDRIS | ||||
ELRDKQAELQ | DEPKHANCCT | YCPKSFKKPS | DLVRHVRIHT | GEKPYKCDEC | ||||
GKSFTVKSTL | DCHVKTHTGQ | KLFSCHVCSN | AFSTKGSLKV | HMRLHTGAKP | ||||
FKCPHCELRF | RTSGRRKTHM | QFHYKPDPKK | ARKPMTRSSS | EGLQPVNLLN | ||||
SSSTDPNVFI | MNNSVLTGQF | DQNLLQPGLV | GQAILPASVS | AGGDLTVSLT | ||||
DGSLATLEGI | QLQLAANLVG | PNVQISGIDA | ASINNITLQI | DPSILQQTLQ | ||||
QGNLLAQQLT | GEPGLAPQNS | SLQTSDSTVP | ASVVIQPISG | LSLQPTVTSA | ||||
NLTIGPLSEQ | DSVLTTNSSG | TQDLTQVMTS | QGLVSPSGGP | HEITLTINNS | ||||
SLSQVLAQAA | GPTATSSSGS | PQEITLTISE | LNTTSGSLPS | TTPMSPSAIS | ||||
TQNLVMSSSG | VGGDASVTLT | LADTQGMLSG | GLDTVTLNIT | SQGQQFPALL | ||||
TDPSLSGQGG | AGSPQVILVS | HTPQSASAAC | EEIAYQVAGV | SGNLAPGNQP | ||||
EKEGRAHQCL | ECDRAFSSAA | VLMHHSKEVH | GRERIHGCPV | CRKAFKRATH | ||||
LKEHMQTHQA | GPSLSSQKPR | VFKCDTCEKA | FAKPSQLERH | SRIHTGERPF | ||||
HCTLCEKAFN | QKSALQVHMK | KHTGERPYKC | AYCVMGFTQK | SNMKLHMKRA | ||||
HSYAGALQES | AGHPEQDGEE | LSRTLHLEEV | VQEAAGEWQA | LTHVF |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000130856 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041258 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Zinc finger protein 236".
- ^ "UniProt, Q9UL36". Pristupljeno 12. 9. 2017.
Dopunska literatura
uredi- Holmes DI, Abdel Wahab N, Mason RM (septembar 1997). "Identification of glucose-regulated genes in human mesangial cells by mRNA differential display". Biochemical and Biophysical Research Communications. 238 (1): 179–84. doi:10.1006/bbrc.1997.7265. PMID 9299475.
- Low SK, Chung S, Takahashi A, Zembutsu H, Mushiroda T, Kubo M, Nakamura Y (august 2013). "Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan". Cancer Science. 104 (8): 1074–82. doi:10.1111/cas.12186. PMC 7657179. PMID 23648065. S2CID 5954226.
- Holmes DI, Wahab NA, Mason RM (august 1999). "Cloning and characterization of ZNF236, a glucose-regulated Kruppel-like zinc-finger gene mapping to human chromosome 18q22-q23". Genomics. 60 (1): 105–9. doi:10.1006/geno.1999.5897. PMID 10458916.
- McDonough CW, Bostrom MA, Lu L, Hicks PJ, Langefeld CD, Divers J, Mychaleckyj JC, Freedman BI, Bowden DW (decembar 2009). "Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping". Human Genetics. 126 (6): 805–17. doi:10.1007/s00439-009-0732-8. PMC 2937163. PMID 19690890.
- Halama N, Yard-Breedijk A, Vardarli I, Akkoyun I, Yard B, Janssen B, van der Woude FJ (septembar 2003). "The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced and excluded as susceptibility gene for diabetic nephropathy". Genomics. 82 (3): 406–11. doi:10.1016/s0888-7543(03)00120-4. PMID 12906866.