ZGPAT

CCCH-tip cinkovog prsta sa G-parčetom domen-sadržavajućeg proteina je protein koji je kod ljudi kodiran genom ZGPAT.

ZGPAT
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4II1
Identifikatori
Aliasi	ZGPAT
Vanjski ID-jevi	MGI: 2449939 HomoloGene: 41874 GeneCards: ZGPAT
Lokacija gena (čovjek) Hrom. Hromosom 20 (čovjek) Bend 20q13.33 Početak 63,707,465 bp Kraj 63,736,142 bp
Lokacija gena (miš) Hrom. Hromosom 2 (miš) Bend 2|2 H4 Početak 181,006,721 bp Kraj 181,025,421 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • sequence-specific DNA binding • vezivanje sa DNK • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • jedro • ćelijska membrana Biološki proces • negative regulation of epidermal growth factor-activated receptor activity • GO:0045996 negative regulation of transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	84619	229007
Ensembl	ENSG00000197114	ENSMUSG00000027582
UniProt	Q8N5A5	Q8VDM1
RefSeq (mRNK)	NM_181485 NM_001083113 NM_001195653 NM_001195654 NM_032527 NM_181484	NM_001048148 NM_144894
RefSeq (bjelančevina)	NP_001076582 NP_001182582 NP_001182583 NP_115916 NP_852150	NP_001041613 NP_659143
Lokacija (UCSC)	Chr 20: 63.71 – 63.74 Mb	Chr 2: 181.01 – 181.03 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ontologija

Molekulska funkcija

• GO: 0001131, GO: 0001151, GO: 0001130, GO: 0001204
• Aktivnost DNK-vezujućeg transkripcijskog faktora
• GO: 0000980 RNA polimeraza II za specifično za sekvencu cis-regulatorno područje vezivanja DNK
• vezanje DNK specifično za sekvence
• Vezanje DNK
• GO: 0001078, GO: 0001214, GO: 0001206 Represorska aktivnost transkripcije koja veže DNK, specifična za RNK polimerazu II
• GO: 0001948 vezanje za proteine
• vezanje metalnih iona
• vezanje nukleinske kiseline
• GO: 0001200, GO: 0001133, GO: 0001201 aktivnost transkripcionog faktora koji veže DNK, specifična za RNA polimerazu II

Ćelijska komponenta

• jedro
• plazmamembrana

Biološki proces

• negativna regulacija aktivnosti receptora aktiviranog epidermnim faktorom rasta
• negativna regulacija transkripcije, sa predloškom DNK
• regulacija transkripcije, sa predloškom DNK
• negativna regulacija transkripcije RNK-polimerazom II
• transkripcija, DNK predložak

Izvori: Amigo / QuickGO

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MDEESLESAL		QTYRAQLQQV		ELALGAGLDS		SEQADLRQLQ		GDLKELIELT
EASLVSVRKS		SLLAALDEER		PGRQEDAEYQ		AFREAITEAV		EAPAAARGSG
SETVPKAEAG		PESAAGGQEE		EEGEDEEELS		GTKVSAPYYS		SWGTLEYHNA
MVVGTEEAED		GSAGVRVLYL		YPTHKSLKPC		PFFLEGKCRF		KENCRFSHGQ
VVSLDELRPF		QDPDLSSLQA		GSACLAKHQD		GLWHAARITD		VDNGYYTVKF
DSLLLREAVV		EGDGILPPLR		TEATESDSDS		DGTGDSSYAR		VVGSDAVDSA
QSSALCPSLA		VVGSDAVDSG		TCSSAFAGWE		VHTRGIGSRL		LTKMGYEFGK
GLGRHAEGRV		EPIHAVVLPR		GKSLDQCVET		LQKQTRVGKA		GTNKPPRCRG
RGARPGGRPA		PRNVFDFLNE		KLQGQAPGAL		EAGAAPAGRR		SKDMYHASKS
AKRALSLRLF		QTEEKIERTQ		RDIRSIQEAL		ARNAGRHSVA		SAQLQEKLAG
AQRQLGQLRA		QEAGLQQEQR		KADTHKKMTE		F

Dopunska literatura

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Rual JF, Hirozane-Kishikawa T, Hao T, et al. (2004). "Human ORFeome Version 1.1: A Platform for Reverse Proteomics". Genome Res. 14 (10B): 2128–35. doi:10.1101/gr.2973604. PMC 528929. PMID 15489335.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.