TMEPAI

TMEPAI
Identifikatori
Aliasi	PMEPA1
Vanjski ID-jevi	OMIM: 606564 MGI: 1929600 HomoloGene: 10608 GeneCards: PMEPA1
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	57,711,536 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	173,118,326 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• WW domain binding; • R-SMAD binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• integral component of membrane; • Golđijeva membrana; • endozom; • ćelijska membrana; • Golđijev aparat; • early endosome membrane; • endosome membrane; • intracellular membrane-bounded organelle; • membrana;
Biološki proces	• androgen receptor signaling pathway; • negative regulation of signal transduction; • negative regulation of transforming growth factor beta receptor signaling pathway; • negative regulation of pathway-restricted SMAD protein phosphorylation; • negative regulation of SMAD protein complex assembly;
	Izvori:Amigo / QuickGO
Ortolozi
	56937
	65112
	ENSG00000124225
	ENSMUSG00000038400
	Q969W9
	Q9D7R2
	NM_199171; NM_001255976; NM_020182; NM_199169; NM_199170
	NM_022995
	NP_001242905; NP_064567; NP_954638; NP_954639; NP_954640
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Transmembranski prostatni androgen-induciran protein je protein koji je kod ljudi kodiran genom PMEPA1.^[5]^[6]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MHRLMGVNST	AAAAAGQPNV	SCTCNCKRSL	FQSMEITELE	FVQIIIIVVV
MMVMVVVITC	LLSHYKLSAR	SFISRHSQGR	RREDALSSEG	CLWPSESTVS
GNGIPEPQVY	APPRPTDRLA	VPPFAQRERF	HRFQPTYPYL	QHEIDLPPTI
SLSDGEEPPP	YQGPCTLQLR	DPEQQLELNR	ESVRAPPNRT	IFDSDLMDSA
RLGGPCPPSS	NSGISATCYG	SGGRMEGPPP	TYSEVIGHYP	GSSFQHQQSS
GPPSLLEGTR	LHHTHIAPLE	SAAIWSKEKD	KQKGHPL

Interakcije

Pokazano je da TMEPAI ima interakciju sa NEDD4.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124225 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038400 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Xu LL, Shanmugam N, Segawa T, Sesterhenn IA, McLeod DG, Moul JW, Srivastava S (Jun 2000). "A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate". Genomics. 66 (3): 257–63. doi:10.1006/geno.2000.6214. PMID 10873380.
^ "Entrez Gene: TMEPAI transmembrane, prostate androgen induced RNA".
^ Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S (Aug 2003). "PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression". Cancer Research. 63 (15): 4299–304. PMID 12907594.

Dopunska literatura

Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S (Nov 2000). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". The Biochemical Journal. 351 Pt 3 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394. PMID 11042109.
Rae FK, Hooper JD, Nicol DL, Clements JA (Sep 2001). "Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors". Molecular Carcinogenesis. 32 (1): 44–53. doi:10.1002/mc.1063. PMID 11568975. S2CID 46602128.
Brunschwig EB, Wilson K, Mack D, Dawson D, Lawrence E, Willson JK, Lu S, Nosrati A, Rerko RM, Swinler S, Beard L, Lutterbaugh JD, Willis J, Platzer P, Markowitz S (Apr 2003). "PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer". Cancer Research. 63 (7): 1568–75. PMID 12670906.
Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S (Aug 2003). "PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression". Cancer Research. 63 (15): 4299–304. PMID 12907594.
Giannini G, Ambrosini MI, Di Marcotullio L, Cerignoli F, Zani M, MacKay AR, Screpanti I, Frati L, Gulino A (Dec 2003). "EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer". Molecular Carcinogenesis. 38 (4): 188–200. doi:10.1002/mc.10162. PMID 14639658. S2CID 22894125.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (maj 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124225 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038400 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10873380-5] Xu LL, Shanmugam N, Segawa T, Sesterhenn IA, McLeod DG, Moul JW, Srivastava S (Jun 2000). "A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate". Genomics. 66 (3): 257–63. doi:10.1006/geno.2000.6214. PMID 10873380.

[entrez-6] "Entrez Gene: TMEPAI transmembrane, prostate androgen induced RNA".

[pmid12907594-7] Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S (Aug 2003). "PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression". Cancer Research. 63 (15): 4299–304. PMID 12907594.

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