Transmembranski prostatni androgen-induciran protein je protein koji je kod ljudi kodiran genom PMEPA1.[5][6]

TMEPAI
Identifikatori
AliasiPMEPA1
Vanjski ID-jeviOMIM: 606564 MGI: 1929600 HomoloGene: 10608 GeneCards: PMEPA1
Lokacija gena (čovjek)
Hromosom 20 (čovjek)
Hrom.Hromosom 20 (čovjek)[1]
Hromosom 20 (čovjek)
Genomska lokacija za TMEPAI
Genomska lokacija za TMEPAI
Bend20q13.31Početak57,648,392 bp[1]
Kraj57,711,536 bp[1]
Lokacija gena (miš)
Hromosom 2 (miš)
Hrom.Hromosom 2 (miš)[2]
Hromosom 2 (miš)
Genomska lokacija za TMEPAI
Genomska lokacija za TMEPAI
Bend2|2 H3Početak173,066,251 bp[2]
Kraj173,118,326 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija WW domain binding
R-SMAD binding
GO:0001948, GO:0016582 protein binding
Ćelijska komponenta integral component of membrane
Golđijeva membrana
endozom
Ćelijska membrana
Golđijev aparat
early endosome membrane
endosome membrane
intracellular membrane-bounded organelle
membrana
Biološki proces androgen receptor signaling pathway
negative regulation of signal transduction
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of SMAD protein complex assembly
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_199171
NM_001255976
NM_020182
NM_199169
NM_199170

NM_022995

RefSeq (bjelančevina)

NP_001242905
NP_064567
NP_954638
NP_954639
NP_954640

n/a

Lokacija (UCSC)Chr 20: 57.65 – 57.71 MbChr 2: 173.07 – 173.12 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca uredi

Simboli
1020304050
MHRLMGVNSTAAAAAGQPNVSCTCNCKRSLFQSMEITELEFVQIIIIVVV
MMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVS
GNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQPTYPYLQHEIDLPPTI
SLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSA
RLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSS
GPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL

Interakcije uredi

Pokazano je da TMEPAI ima interakciju sa NEDD4.[7]

Reference uredi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124225 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038400 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Xu LL, Shanmugam N, Segawa T, Sesterhenn IA, McLeod DG, Moul JW, Srivastava S (Jun 2000). "A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate". Genomics. 66 (3): 257–63. doi:10.1006/geno.2000.6214. PMID 10873380.
  6. ^ "Entrez Gene: TMEPAI transmembrane, prostate androgen induced RNA".
  7. ^ Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S (Aug 2003). "PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression". Cancer Research. 63 (15): 4299–304. PMID 12907594.

Dopunska literatura uredi

  • Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S (Nov 2000). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". The Biochemical Journal. 351 Pt 3 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394. PMID 11042109.
  • Rae FK, Hooper JD, Nicol DL, Clements JA (Sep 2001). "Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors". Molecular Carcinogenesis. 32 (1): 44–53. doi:10.1002/mc.1063. PMID 11568975. S2CID 46602128.
  • Brunschwig EB, Wilson K, Mack D, Dawson D, Lawrence E, Willson JK, Lu S, Nosrati A, Rerko RM, Swinler S, Beard L, Lutterbaugh JD, Willis J, Platzer P, Markowitz S (Apr 2003). "PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer". Cancer Research. 63 (7): 1568–75. PMID 12670906.
  • Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S (Aug 2003). "PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression". Cancer Research. 63 (15): 4299–304. PMID 12907594.
  • Giannini G, Ambrosini MI, Di Marcotullio L, Cerignoli F, Zani M, MacKay AR, Screpanti I, Frati L, Gulino A (Dec 2003). "EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer". Molecular Carcinogenesis. 38 (4): 188–200. doi:10.1002/mc.10162. PMID 14639658. S2CID 22894125.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (maj 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.