SC65

Sinaptonemni kompleksni protein SC65, znan i kao leprelanoliki protein 4 (LEPREL4) ili jedarčani autoantigen No55, je protein koji je kod ljudi kodiran genom LEPREL4.

SC65
Identifikatori
Aliasi	P3H4
Vanjski ID-jevi	OMIM: 617419 MGI: 1913430 HomoloGene: 4713 GeneCards: P3H4
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek) Bend 17q21.2 Početak 41,801,947 bp Kraj 41,812,604 bp
Lokacija gena (miš) Hrom. Hromosom 11 (miš) Bend 11|11 D Početak 100,299,282 bp Kraj 100,305,662 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ortolozi
Vrste	Čovjek	Miš
Entrez	10609	66180
Ensembl	ENSG00000141696	ENSMUSG00000006931
UniProt	Q92791	Q8K2B0
RefSeq (mRNK)	NM_006455	NM_176830 NM_001378981
RefSeq (bjelančevina)	NP_006446	NP_789800 NP_001365910
Lokacija (UCSC)	Chr 17: 41.8 – 41.81 Mb	Chr 11: 100.3 – 100.31 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Dužina polipeptidnog lanca je 437 aminokiselina, a molekulska težina 50.381..

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin

N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MARVAWGLLW		LLLGSAGAQY		EKYSFRGFPP		EDLMPLAAAY		GHALEQYEGE
SWRESARYLE		AALRLHRLLR		DSEAFCHANC		SGPAPAAKPD		PDGGRADEWA
CELRLFGRVL		ERAACLRRCK		RTLPAFQVPY		PPRQLLRDFQ		SRLPYQYLHY
ALFKANRLEK		AVAAAYTFLQ		RNPKHELTAK		YLNYYQGMLD		VADESLTDLE
AQPYEAVFLR		AVKLYNSGDF		RSSTEDMERA		LSEYLAVFAR		CLAGCEGAHE
QVDFKDFYPA		IADLFAESLQ		CKVDCEANLT		PNVGGYFVDK		FVATMYHYLQ
FAYYKLNDVR		QAARSAASYM		LFDPKDSVMQ		QNLVYYRFHR		ARWGLEEEDF
QPREEAMLYH		NQTAELRELL		EFTHMYLQSD		DEMELEETEP		PLEPEDALSD
AEFEGEGDYE		EGMYADWWQE		PDAKGDEAEA		EPEPELA

Funkcija

Ovaj nukleolusni protein prvo je okarakteriziran jer je bio autoantigen u slučajevima na intersticijski cistitis. Izgleda da je protein, s predviđenom molekulskom težinom od 50 kDa, lokaliziran u odjeljku čestica u interfazi jedarceta, s distribucijom koja se razlikuje od distribucije nukleolusnog proteina B23. Tokom mitoze povezan je sa hromosomima.

Dopunska literatura

• Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fosså A, Siebert R, Aasheim HC, et al. (2000). "Identification of nucleolar protein No55 as a tumour-associated autoantigen in patients with prostate cancer". Br. J. Cancer. 83 (6): 743–9. doi:10.1054/bjoc.2000.1365. PMC 2363543. PMID 10952778.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Ochs RL, Stein TW, Chan EK, et al. (1996). "cDNA cloning and characterization of a novel nucleolar protein". Mol. Biol. Cell. 7 (7): 1015–24. doi:10.1091/mbc.7.7.1015. PMC 275955. PMID 8862517.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.