OMG (gen)

Oligodendrocitno-mijelinski glikoprotein je protein koji je kod ljudi kodiran genom OMG.

OMG (gen)
Identifikatori
Aliasi	OMG
Vanjski ID-jevi	OMIM: 164345 MGI: 106586 HomoloGene: 36099 GeneCards: OMG
Lokacija gena (miš) Hrom. Hromosom 11 (miš) Bend 11 B5|11 46.79 cM Početak 79,391,808 bp Kraj 79,394,910 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ortolozi
Vrste	Čovjek	Miš
Entrez	4974	18377
Ensembl	n/a	ENSMUSG00000049612
UniProt	P23515	Q63912
RefSeq (mRNK)	NM_002544	NM_019409
RefSeq (bjelančevina)	NP_002535	NP_062282
Lokacija (UCSC)	n/a	Chr 11: 79.39 – 79.39 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Dužina polipeptidnog lanca je 440 aminokiselina, sa molekulskom težinom od 49.608.

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MEYQILKMSL		CLFILLFLTP		GILCICPLQC		ICTERHRHVD		CSGRNLSTLP
SGLQENIIHL		NLSYNHFTDL		HNQLTQYTNL		RTLDISNNRL		ESLPAHLPRS
LWNMSAANNN		IKLLDKSDTA		YQWNLKYLDV		SKNMLEKVVL		IKNTLRSLEV
LNLSSNKLWT		VPTNMPSKLH		IVDLSNNSLT		QILPGTLINL		TNLTHLYLHN
NKFTFIPDQS		FDQLFQLQEI		TLYNNRWSCD		HKQNITYLLK		WMMETKAHVI
GTPCSTQISS		LKEHNMYPTP		SGFTSSLFTV		SGMQTVDTIN		SLSVVTQPKV
TKIPKQYRTK		ETTFGATLSK		DTTFTSTDKA		FVPYPEDTST		ETINSHEAAA
ATLTIHLQDG		MVTNTSLTSS		TKSSPTPMTL		SITSGMPNNF		SEMPQQSTTL
NLWREETTTN		VKTPLPSVAN		AWKVNASFLL		LLNVVVMLAV

Dopunska literatura

• Mikol DD, Gulcher JR, Stefansson K (1990). "The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate". J. Cell Biol. 110 (2): 471–9. doi:10.1083/jcb.110.2.471. PMC 2116011. PMID 1688857.
• Mikol DD, Stefansson K (1988). "A phosphatidylinositol-linked peanut agglutinin-binding glycoprotein in central nervous system myelin and on oligodendrocytes". J. Cell Biol. 106 (4): 1273–9. doi:10.1083/jcb.106.4.1273. PMC 2115011. PMID 3283151.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Mikol DD, Rongnoparut P, Allwardt BA, et al. (1993). "The oligodendrocyte-myelin glycoprotein of mouse: primary structure and gene structure". Genomics. 17 (3): 604–10. doi:10.1006/geno.1993.1379. PMID 8244377.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wang KC, Koprivica V, Kim JA, et al. (2002). "Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth". Nature. 417 (6892): 941–4. doi:10.1038/nature00867. PMID 12068310. S2CID 5734715.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Vourc'h P, Moreau T, Arbion F, et al. (2003). "Oligodendrocyte myelin glycoprotein growth inhibition function requires its conserved leucine-rich repeat domain, not its glycosylphosphatidyl-inositol anchor". J. Neurochem. 85 (4): 889–97. doi:10.1046/j.1471-4159.2003.01764.x. PMID 12716421. S2CID 30250786.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Venturin M, Moncini S, Villa V, et al. (2007). "Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation" (PDF). Neurogenetics. 7 (1): 59–66. doi:10.1007/s10048-005-0026-9. hdl:2434/10108. PMID 16425041. S2CID 24738309.
• Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–5. doi:10.1038/ng2083. PMID 17632510. S2CID 35797973.