MRCL3

Miozinski regulatorni lahki lanac 12A je protein koji je kod ljudi kodiran genom MYL12A.

MRCL3
Identifikatori
Aliasi	MYL12A
Vanjski ID-jevi	MGI: 107494 HomoloGene: 23407 GeneCards: MYL12A
Lokacija gena (čovjek) Hrom. Hromosom 18 (čovjek) Bend 18p11.31 Početak 3,247,481 bp Kraj 3,256,236 bp
Lokacija gena (miš) Hrom. Hromosom 17 (miš) Bend 17|17 E1.3 Početak 71,280,128 bp Kraj 71,297,885 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • calcium ion binding • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala • myosin heavy chain binding Ćelijska komponenta • citosol • Egzosom • myosin complex • myosin II complex • apical part of cell • Z discdkac • brush border • stress fiber • cell cortex region Biološki proces • ephrin receptor signaling pathway • Mišićna kontrakcija • platelet aggregation • regulation of cell shape Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	10627	67938
Ensembl	ENSG00000101608	ENSMUSG00000034868
UniProt	P19105 O14950	Q3THE2
RefSeq (mRNK)	NM_001303047 NM_001303048 NM_001303049 NM_006471	NM_023402
RefSeq (bjelančevina)	NP_001289976 NP_001289977 NP_001289978 NP_006462 NP_001138416 NP_001138417 NP_291024 NP_001289976 NP_001289977 NP_001289978 NP_006462	NP_075891
Lokacija (UCSC)	Chr 18: 3.25 – 3.26 Mb	Chr 17: 71.28 – 71.3 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Dužina polipeptidnog lanca je 171 aminokiselina, a molekulska masa mu je 19.794.

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MSSKRTKTKT		KKRPQRATSN		VFAMFDQSQI		QEFKEAFNMI		DQNRDGFIDK
EDLHDMLASL		GKNPTDEYLD		AMMNEAPGPI		NFTMFLTMFG		EKLNGTDPED
VIRNAFACFD		EEATGTIQED		YLRELLTTMG		DRFTDEEVDE		LYREAPIDKK
GNFNYIEFTR		ILKHGAKDKD		D

Dopunska literatura

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• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Iwasaki T, Murata-Hori M, Ishitobi S, Hosoya H (2002). "Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells". Cell Struct. Funct. 26 (6): 677–83. doi:10.1247/csf.26.677. PMID 11942626.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.