Protein 48 sa ponavljanjem i bogat leucinom je protein koji je kod ljudi kodiran genom LRRC48.[5][6][7]
Dužina polipeptidnog lanca je 523 aminokiseline, sa molekulskom težinom od 61.054.[8]
Aminokiselinska sekvenca
- Simboli
| 10 | | 20 | | 30 | | 40 | | 50 |
|---|
| MNQPCNSMEP | | RVMDDDMLKL | | AVGDQGPQEE | | AGQLAKQEGI | | LFKDVLSLQL |
| DFRNILRIDN | | LWQFENLRKL | | QLDNNIIEKI | | EGLENLAHLV | | WLDLSFNNIE |
| TIEGLDTLVN | | LEDLSLFNNR | | ISKIDSLDAL | | VKLQVLSLGN | | NRIDNMMNII |
| YLRRFKCLRT | | LSLSRNPISE | | AEDYKMFICA | | YLPDLMYLDY | | RRIDDHTKKL |
| AEAKHQYSID | | ELKHQENLMQ | | AQLEDEQAQR | | EELEKHKTAF | | VEHLNGSFLF |
| DSMYAEDSEG | | NNLSYLPGVG | | ELLETYKDKF | | VIICVNIFEY | | GLKQQEKRKT |
| ELDTFSECVR | | EAIQENQEQG | | KRKIAKFEEK | | HLSSLSAIRE | | ELELPNIEKM |
| ILECSADISE | | LFDALMTLEM | | QLVEQLEETI | | NMFERNIVDM | | VGLFIENVQS |
| LMAQCRDLEN | | HHHEKLLEIS | | ISTLEKIVEG | | DLDEDLPNDL | | RALFVDKDTI |
| VNAVGASHDI | | HLLKIDNRED | | ELVTRINSWC | | TRLIDRIHKD | | EIMRNRKRVK |
| EINQYIDHMQ | | SELDNLECGD | | ILD |
- ^ a b c GRCh38: Ensembl release 89: ENSG00000171962 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056598 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- ^ Bi W, Yan J, Stankiewicz P, Park SS, Walz K, Boerkoel CF, Potocki L, Shaffer LG, Devriendt K, Nowaczyk MJ, Inoue K, Lupski JR (maj 2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC 186594. PMID 11997338.
- ^ "Entrez Gene: LRRC48 leucine rich repeat containing 48".
- ^ "UniProt, Q9H069". Pristupljeno 12. 9. 2017.
Dopunska literatura
uredi
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Lucas RE, Vlangos CN, Das P, et al. (2002). "Genomic organisation of the approximately 1.5 Mb Smith-Magenis syndrome critical interval: transcription map, genomic contig, and candidate gene analysis". Eur. J. Hum. Genet. 9 (12): 892–902. doi:10.1038/sj.ejhg.5200734. PMID 11840190.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
