Regulator rasta estrogenom u raku dojke je protein koji je kod ljudi kodiran genom GREB1L.[5]

GREB1L
Identifikatori
AliasiGREB1L
Vanjski ID-jeviOMIM: 617782 MGI: 3576497 HomoloGene: 73393 GeneCards: GREB1L
Lokacija gena (čovjek)
Hromosom 18 (čovjek)
Hrom.Hromosom 18 (čovjek)[1]
Hromosom 18 (čovjek)
Genomska lokacija za GREB1L
Genomska lokacija za GREB1L
Bend18q11.1-q11.2Početak21,242,232 bp[1]
Kraj21,526,112 bp[1]
Lokacija gena (miš)
Hromosom 18 (miš)
Hrom.Hromosom 18 (miš)[2]
Hromosom 18 (miš)
Genomska lokacija za GREB1L
Genomska lokacija za GREB1L
Bend18|18 A1Početak10,325,177 bp[2]
Kraj10,562,940 bp[2]
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001142966
NM_024935

NM_001083628

RefSeq (bjelančevina)

NP_001136438

NP_001077097

Lokacija (UCSC)Chr 18: 21.24 – 21.53 MbChr 18: 10.33 – 10.56 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Dužina polipeptidnog lanca u proteinu je 1.923 aminokiseline, а molekulska masa — 214.354[6].

Aminokiselinska sekvenca

Simboli
1020304050
MGNSYAGQLKSARFEEALHNSIEASLRCSSVVPRPIFSQLYLDPDQHPFS
SADVKPKVEDLDKDLVNRYTQNGSLDFSNNLTVNEMEDDEDDEEMSDSNS
PPIPYSQKPAPEGSCTTDGFCQAGKDLRLVSLCMEQIDIPAGFLLVGAKS
PNLPEHILVCAVDKRFLPDDHGKNALLGFSGNCIGCGERGFRYFTEFSNH
INLKLTTQPKKQKHLKYYLVRSSQGVLSKGPLICWKECRSRQSSASCHSI
KPSSSVSSTVTPENGTTNGYKSGFTQTDAANGNSSHGGKGSASSSTPAHT
GNYSLSPRPSYASGDQATMFISGPPKKRHRGWYPGSPLPQPGLVVPVPTV
RPLSRTEPLLSAPVPQTPLTGILQPRPIPAGETVIVPENLLSNSGVRPVI
LIGYGTLPYFYGNVGDIVVSPLLVNCYKIPQLENKDLEKLGLTGSQFLSV
ENMILLTIQYLVRLGPDQVPLREEFEQIMLKAMQEFTLRERALQIGAQCV
PVSPGQLPWLARLIASVSQDLVHVVVTQNSLAEGISETLRTLSEMRHYQR
LPDYVVVICASKIRGNEFCVVVLGQHQSRALAESMLTTSEFLKEISYELI
TGKVSFLASHFKTTSLGDDLDKLLEKMQQRRGDSVVTPFDGDLNECVSPQ
EAAAMIPTQNLDLDNETFHIYQPQLTVARKLLSQVCAIADSGSQSLDLGH
FSKVDFIIIVPRSEVLVQQTLQRIRQSGVLVDLGLEENGTAHQRAEKYVV
RLDNEIQTKFEVFMRRVKQNPYTLFVLVHDNSHVELTSVISGSLSHSEPS
HGLADRVINCREVLEAFNLLVLQVSSFPYTLQTQQSRISSSNEVHWIQLD
TGEDVGCEEKLYFGLSEYSKSLQWGITSPLLRCDETFEKMVNTLLERYPR
LHSMVVRCYLLIQQYSEALMALTTMASLRDHSTPETLSIMDDLISSPGKN
KSGRGHMLIIRVPSVQLAMLAKERLQEVRDKLGLQYRFEIILGNPATELS
VATHFVARLKSWRGNEPEEWIPRTYQDLDGLPCIVILTGKDPLGETFPRS
LKYCDLRLIDSSYLTRTALEQEVGLACCYVSKEVIRGPTVALDLSGKEQE
RAAVSENDSDELLIDLERPQSNSSAVTGTSGSIMENGVSSSSTADKSQKQ
SLTPSFQSPATSLGLDEGVSASSAGAGAGETLKQECDSLGPQMASSTTSK
PSSSSSGPRTLPWPGQPIRGCRGPQAALPPVVILSKAAYSLLGSQKSGKL
PSSSSLLPHADVAWVSSLRPLLNKDMSSEEQSLYYRQWTLARQHHADYSN
QLDPASGTRNFHPRRLLLTGPPQVGKTGSYLQFLRILFRMLIRLLEVDVY
DEEEINTDHNESSEVSQSEGEPWPDIESFSKMPFDVSVHDPKYSLMSLVY
TEKLAGVKQEVIKESKVEEPRKRETVSIMLTKYAAYNTFHHCEQCRQYMD
FTSASQMSDSTLHAFTFSSSMLGEEVQLYFIIPKSKESHFVFSKQGKHLE
SMRLPLVSDKNLNAVKSPIFTPSSGRHEHGLLNLFHAMEGISHLHLLVVK
EYEMPLYRKYWPNHIMLVLPGMFNNAGVGAARFLIKELSYHNLELERNRL
EELGIKRQCVWPFIVMMDDSCVLWNIHSVQEPSSQPMEVGVSSKNVSLKT
VLQHIEATPKIVHYAILGIQKWSSKLTSQSLKAPFSRCHVHDFILLNTDL
TQNVQYDFNRYFCEDADFNLRTNSSGLLICRFNNFSLMKKHVQVGGQRDF
IIKPKIMVSESLAPILPLQYICAPDSEHTLLAAPAQFLLEKFLQHASYKL
FPKAIHNFRSPVLAIDCYLNIGPEVAICYISSRPHSSNVNCEGVFFSGLL
LYLCDSFVGADLKKFKFLKGATLCVICQDRSSLRQTIVRLELEDEWQFRL
RDEFQTANSSDDKPLYFLTGRHV

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141449 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042942 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Growth regulation by estrogen in breast cancer-like". Pristupljeno 9. 10. 2015.
  6. ^ "UniProt, Q9C091". Pristupljeno 12. 9. 2017.

Dopunska literatura

uredi
  • "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14: 2121 — 2127. 2004. PubMed doi:10.1101/gr.2596504