Flotilin-2 je protein koji je kod ljudi kodiran genom FLOT2.[5][6]

FLOT2
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1WIN

Identifikatori
AliasiFLOT2
Vanjski ID-jeviOMIM: 131560 MGI: 103309 HomoloGene: 3293 GeneCards: FLOT2
Lokacija gena (čovjek)
Hromosom 17 (čovjek)
Hrom.Hromosom 17 (čovjek)[1]
Hromosom 17 (čovjek)
Genomska lokacija za FLOT2
Genomska lokacija za FLOT2
Bend17q11.2Početak28,879,335 bp[1]
Kraj28,897,733 bp[1]
Lokacija gena (miš)
Hromosom 11 (miš)
Hrom.Hromosom 11 (miš)[2]
Hromosom 11 (miš)
Genomska lokacija za FLOT2
Genomska lokacija za FLOT2
Bend11 B5|11 46.74 cMPočetak77,928,757 bp[2]
Kraj77,951,260 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija protease binding
GO:0001948, GO:0016582 protein binding
protein heterodimerization activity
ionotropic glutamate receptor binding
Ćelijska komponenta Vezikula
endozom
membrana
cell-cell contact zone
focal adhesion
endocytic vesicle
acrosomal membrane
flotillin complex
uropod
basolateral plasma membrane
apical plasma membrane
cortical actin cytoskeleton
perinuklearno područje citoplazme
Kaveole
Lipidni splav
Egzosom
GO:0016023 citoplazmatska vezikula
lamellipodium
Ćelijska membrana
dendrite cytoplasm
sinapsa
glutamatergic synapse
anchored component of presynaptic active zone membrane
Biološki proces positive regulation of establishment of T cell polarity
regulation of toll-like receptor 3 signaling pathway
regulation of heterotypic cell-cell adhesion
protein stabilization
negative regulation of amyloid precursor protein catabolic process
negative regulation of gene expression
protein localization to plasma membrane raft
Ćelijska adhezija
membrane raft assembly
regulation of myoblast differentiation
epidermis development
protein localization to plasma membrane
anterograde dendritic transport
regulation of postsynaptic membrane neurotransmitter receptor levels
positive regulation of NF-kappaB transcription factor activity
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_004475
NM_001330170

NM_001040403
NM_001284227
NM_001284228
NM_008028
NM_001362625

NM_001362626
NM_001362627

RefSeq (bjelančevina)

NP_001317099
NP_004466

NP_001035493
NP_001271156
NP_001271157
NP_032054
NP_001349554

NP_001349555
NP_001349556

Lokacija (UCSC)Chr 17: 28.88 – 28.9 MbChr 11: 77.93 – 77.95 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Flotilin 2 (flot-2) je visoko konzervirani protein izoliran iz domena kaveol/ lipidnog splava koji vežu receptore faktora rasta na puteve signalne transdukcije. Flot-2 se veže za PAR-1, poznati uzvodni posrednik glavnih puteva transdukcije signala uključenih u rast ćelija i metastaze, a može uticati na progresiju tumora.[7]

Kaveole su mali domeni na unutrašnjosti ćelijske membrane, uključene u promet vezikula i transdukciju signala. Ovaj gen kodira integrirani membranski protein povezan s kaveolama, za koji se smatra da djeluje u neuronskoj signalizaciji.[6]

Dužina polipeptidnog lanca je 428 aminokiselina, a molekulska težina 47.064 Da.[8].

Aminokiselinska sekvenca

Simboli
1020304050
MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIM
TLQPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIK
NVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEIL
SFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKE
MLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQ
KIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQI
AEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK
YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA
ELPASVHALTGVDLSKIPLIKKATGVQV

Reference uredi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132589 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061981 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schroeder WT, Siciliano MJ, Stewart-Galetka SL, Duvic M (Feb 1992). "The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12". Genomics. 11 (2): 481–2. doi:10.1016/0888-7543(91)90166-C. PMID 1769667.
  6. ^ a b "Entrez Gene: FLOT2 flotillin 2".
  7. ^ Hazarika P, McCarty MF, Prieto VG, George S, Babu D, Koul D, Bar-Eli M, Duvic M (Oct 2004). "Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1". Cancer Res. 64 (20): 7361–9. doi:10.1158/0008-5472.CAN-04-0823. PMID 15492257.
  8. ^ "UniProt, Q14254". Pristupljeno 21. 6. 2021.

Dopunska literatura uredi