Protein 1 biosinteze diftamida je protein koji je kod ljudi kodiran genom DPH1.[5][6][7] Kodira protein koji obavlja posttranslacijsku modifikaciju histidina-715[8] na eukariotskom faktoru 2 elongacije tokom tanslacije u diftamid. Čini se da je ova modifikacija važna u translaciji ciklina D u ćelijama jajnika. DPH1 mutira u 90% završne faze karcinoma jajnika, obično uz gubitak heterozigotnosti.

DPH1
Identifikatori
AliasiDPH1
Vanjski ID-jeviOMIM: 603527 MGI: 2151233 HomoloGene: 1059 GeneCards: DPH1
Lokacija gena (čovjek)
Hromosom 17 (čovjek)
Hrom.Hromosom 17 (čovjek)[1]
Hromosom 17 (čovjek)
Genomska lokacija za DPH1
Genomska lokacija za DPH1
Bend17p13.3Početak2,030,137 bp[1]
Kraj2,043,898 bp[1]
Lokacija gena (miš)
Hromosom 11 (miš)
Hrom.Hromosom 11 (miš)[2]
Hromosom 11 (miš)
Genomska lokacija za DPH1
Genomska lokacija za DPH1
Bend11 B5|11 45.76 cMPočetak75,068,469 bp[2]
Kraj75,082,067 bp[2]
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 vezivanje za proteine
aktivnost sa transferazom
Ćelijska komponenta citoplazma
citosol
jedro
nukleoplazma
međućelijske veze
Biološki proces Ćelijska proliferacija
peptidyl-diphthamide biosynthetic process from peptidyl-histidine
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001346574
NM_001346575
NM_001346576
NM_001383

NM_144491

RefSeq (bjelančevina)

NP_001333503
NP_001333504
NP_001333505
NP_001374

NP_652762

Lokacija (UCSC)Chr 17: 2.03 – 2.04 MbChr 11: 75.07 – 75.08 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Dužina polipeptidnog lanca je 443 aminokiseline, sa molekulskom težinom od 48.805.[9]

Aminokiselinska sekvenca

Simboli
1020304050
MRRQVMAALVVSGAAEQGGRDGPGRGRAPRGRVANQIPPEILKNPQLQAA
IRVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFT
EAEVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLIPMDTSAQDFRV
LYVFVDIRIDTTHLLDSLRLTFPPATALALVSTIQFVSTLQAAAQELKAE
YRVSVPQCKPLSPGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPN
VPAYRYDPYSKVLSREHYDHQRMQAARQEAIATARSAKSWGLILGTLGRQ
GSPKILEHLESRLRALGLSFVRLLLSEIFPSKLSLLPEVDVWVQVACPRL
SIDWGTAFPKPLLTPYEAAVALRDISWQQPYPMDFYAGSSLGPWTVNHGQ
DRRPHAPGRPARGKVQEGSARPPSAVACEDCSCRDEKVAPLAP

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108963 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078789 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Phillips NJ, Zeigler MR, Deaven LL (maj 1996). "A cDNA from the ovarian cancer critical region of deletion on chromosome 17p13.3". Cancer Lett. 102 (1–2): 85–90. doi:10.1016/0304-3835(96)04169-9. PMID 8603384.
  6. ^ Liu S, Milne GT, Kuremsky JG, Fink GR, Leppla SH (Oct 2004). "Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2". Mol Cell Biol. 24 (21): 9487–97. doi:10.1128/MCB.24.21.9487-9497.2004. PMC 522255. PMID 15485916.
  7. ^ "Entrez Gene: DPH1 DPH1 homolog (S. cerevisiae)".
  8. ^ Webb TR, Cross SH, McKie L, Edgar R, Vizor L, Harrison J, Peters J, Jackson IJ (2008). "Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development". J. Cell Sci. 121 (Pt 19): 3140–5. doi:10.1242/jcs.035550. PMC 2592597. PMID 18765564. Diphthamide modification is present in all eukaryotic organisms, in which it is restricted to a histidine residue of translation elongation factor 2 (eEF2, also known as EFT1; position 715 in mammals and 699 in yeast)
  9. ^ "UniProt, Q9BZG8". Pristupljeno 12. 9. 2017.

Dopunska literatura

uredi