CKMT2

Mitohondrijska kreatin-kinaza S-tipa je enzim koji je kod ljudi kodiran genom CKMT2.

CKMT2
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4Z9M
Identifikatori
Aliasi	CKMT2
Vanjski ID-jevi	OMIM: 123295 MGI: 1923972 HomoloGene: 68206 GeneCards: CKMT2
Lokacija gena (čovjek) Hrom. Hromosom 5 (čovjek) Bend 5q14.1 Početak 81,233,320 bp Kraj 81,266,398 bp
Lokacija gena (miš) Hrom. Hromosom 13 (miš) Bend 13|13 C3 Početak 92,001,506 bp Kraj 92,025,004 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • aktivnost sa transferazom • creatine kinase activity • nucleotide binding • transferase activity, transferring phosphorus-containing groups • catalytic activity • ATP binding • kinase activity Ćelijska komponenta • mitochondrial inner membrane • membrana • mitohondrija Biološki proces • creatine metabolic process • Mišićna kontrakcija • Fosforilacija • phosphocreatine biosynthetic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	1160	76722
Ensembl	ENSG00000131730	ENSMUSG00000021622
UniProt	P17540	Q6P8J7
RefSeq (mRNK)	NM_001825 NM_001099735 NM_001099736	NM_198415
RefSeq (bjelančevina)	NP_001093205 NP_001093206 NP_001816 NP_001093205.1 NP_001093206.1 NP_001816.2	NP_940807
Lokacija (UCSC)	Chr 5: 81.23 – 81.27 Mb	Chr 13: 92 – 92.03 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Mitohondrijska kreatin-kinaza (MtCK) odgovorna je za prijenos visokoenergetskog fosfata iz mitohondrija u citosolni nosač, kreatin. "Energetski bogata" gama-fosfatna grupa ATP, koja nastaje oksidativnom fosforilacijom unutar mitohondrija, pretvarajući se tranfosforilacijom u kreatin (Cr) dajući fosfo-kreatin (PCr). Ovaj se zatim iz mitohondrija iznosi u citosol, gdje ga razlažu citosolne kreatin-kinaze (CK), za in situ regeneraciju ATP-a koji je upotrebljen za ćelijske aktivnosti. Cr se zatim vraća u mitohondrije, gdje stimulira mitohondrijsko disanje i ponovo se puni mitohondrijskim ATP-om, putem MtCK. Ovaj proces se naziva PCr/ Cr-šatl ili krug. MtCK pripada porodici izoenzimskih kreatin-kinaza (CK). Postoji kao dva izoenzima, sarkomerni MtCK i sveprisutni MtCK, kodirani odvojenim genima. Mitohondrijska kreatin-kinaza javlja se u dva različita oligomerna oblika: dimeri i oktameri, za razliku od isključivo dimernih izoenzima citosolne kreatin-kinaze. Sarkomerna mitohondrijska kreatin kinaza ima 80% homologija sa kodirajućim egzonima sveprisutne mitohondrijske kreatin-kinaze. Ovaj gen sadrži homologne sekvence nekoliko motiva, koje dijele neki jedarni geni za kodiranje mitohondrijskih proteina. Zato mogu biti presudni za koordiniranu aktivaciju tih gena tokom mitohondrijske biogeneze.

Vanjski linkovi

• Lokacija ljudskog genoma CKMT2 i stranica sa detaljima o genu CKMT2 u UCSC Genome Browseru.

dopunska literatura

• Payne RM, Strauss AW (1995). "Expression of the mitochondrial creatine kinase genes". Mol. Cell. Biochem. 133–134: 235–43. doi:10.1007/BF01267957. PMID 7808456.
• Qin W; Khuchua Z; Cheng J; et al. (1998). "Molecular characterization of the creatine kinases and some historical perspectives". Mol. Cell. Biochem. 184 (1–2): 153–67. doi:10.1023/A:1006807515892. PMID 9746319.
• Klein SC; Haas RC; Perryman MB; et al. (1991). "Regulatory element analysis and structural characterization of the human sarcomeric mitochondrial creatine kinase gene". J. Biol. Chem. 266 (27): 18058–65. PMID 1917943.
• Haas RC; Korenfeld C; Zhang ZF; et al. (1989). "Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase". J. Biol. Chem. 264 (5): 2890–7. PMID 2914937.
• Richard I; Devaud C; Cherif D; et al. (1994). "The gene for creatine kinase, mitochondrial 2 (sarcomeric; CKMT2), maps to chromosome 5q13.3". Genomics. 18 (1): 134–6. doi:10.1006/geno.1993.1437. PMID 8276398.
• Qin W, Khuchua Z, Klein SC, Strauss AW (1997). "Elements regulating cardiomyocyte expression of the human sarcomeric mitochondrial creatine kinase gene in transgenic mice". J. Biol. Chem. 272 (40): 25210–6. doi:10.1074/jbc.272.40.25210. PMID 9312135.
• Qin W; Khuchua Z; Boero J; et al. (1999). "Oxidative myocytes of heart and skeletal muscle express abundant sarcomeric mitochondrial creatine kinase". Histochem. J. 31 (6): 357–65. doi:10.1023/A:1003748108062. PMID 10462222.
• Kanemitsu F; Mizushima J; Kageoka T; et al. (2000). "Characterization of two types of mitochondrial creatine kinase isolated from normal human cardiac muscle and brain tissue". Electrophoresis. 21 (2): 266–70. doi:10.1002/(SICI)1522-2683(20000101)21:2<266::AID-ELPS266>3.0.CO;2-9. PMID 10674997.
• Schlattner U, Wallimann T (2000). "Octamers of mitochondrial creatine kinase isoenzymes differ in stability and membrane binding". J. Biol. Chem. 275 (23): 17314–20. doi:10.1074/jbc.M001919200. PMID 10748055.
• Schlattner U, Wallimann T (2002). "A quantitative approach to membrane binding of human ubiquitous mitochondrial creatine kinase using surface plasmon resonance". J. Bioenerg. Biomembr. 32 (1): 123–31. doi:10.1023/A:1005576831968. PMID 11768757.
• Schlattner U; Möckli N; Speer O; et al. (2002). "Creatine kinase and creatine transporter in normal, wounded, and diseased skin". J. Invest. Dermatol. 118 (3): 416–23. doi:10.1046/j.0022-202x.2001.01697.x. PMID 11874479.
• Wendt S, Schlattner U, Wallimann T (2003). "Differential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residues". J. Biol. Chem. 278 (2): 1125–30. doi:10.1074/jbc.M208572200. PMID 12401781.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Schlattner U; Gehring F; Vernoux N; et al. (2004). "C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase". J. Biol. Chem. 279 (23): 24334–42. doi:10.1074/jbc.M314158200. PMID 15044463.
• Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Guerrero K; Wuyam B; Mezin P; et al. (2005). "Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscle". Am. J. Physiol. Regul. Integr. Comp. Physiol. 289 (4): R1144–54. doi:10.1152/ajpregu.00229.2005. PMID 16020522.