CCL15

Hemokinski (C-C motivni) ligand 15
Hemokinski (C-C motivni) ligand 15
Identifikatori
Simbol	CCL15
Alt. simboli	SCYA15, HCC-2, NCC-3, SCYL3, MIP-5, Lkn-1, MIP-1d, HMRP-2B
NCBI gen	6359
HGNC	10613
OMIM	601393
PDB	2HCC
RefSeq	NM_032965
UniProt	Q16663
Ostali podaci
Lokus	Hrom. 17 q11.2
Strukture
Pretraga za
Strukture	Swiss-model
Domene	InterPro

CCL15
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	2HCC
Identifikatori
Aliasi	CCL15
Vanjski ID-jevi	OMIM: 601393 HomoloGene: 130802 GeneCards: CCL15
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	36,001,553 bp
Ontologija gena
Molekularna funkcija	• cytokine activity; • heparin binding; • CCR chemokine receptor binding; • chemoattractant activity; • signaling receptor binding; • chemokine activity;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• G protein-coupled receptor signaling pathway; • monocyte chemotaxis; • chemokine-mediated signaling pathway; • cell-cell signaling; • cellular response to tumor necrosis factor; • cellular calcium ion homeostasis; • neutrophil chemotaxis; • Hemotaksija; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • cellular response to interleukin-1; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • positive regulation of ERK1 and ERK2 cascade; • cellular response to interferon-gamma; • cell chemotaxis; • lymphocyte chemotaxis; • inflammatory response; • GO:0072468 Transdukcija signala; • positive chemotaxis; • regulation of signaling receptor activity; • eosinophil chemotaxis;
	Izvori:Amigo / QuickGO
Ortolozi
	6359
	n/a
	ENSG00000275718; ENSG00000275528
	n/a
	Q16663
	n/a
	NM_032965; NM_004167; NM_032964
	n/a
	NP_116741
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Hemokinski (C-C motivni) ligand 15 (CCL15) jest mali citokin koji pripada porodici CC hemokina, koji je poznat i kao leukotaktin-1, MIP5 i HCC-2. CCL15 se eksprimira u jetri, tankom i debelom crijevu, te u određenim leukocitima i makrofagima pluća.^[3] Hemotaksijski
je za neutrofile, monocite i limfocite i izaziva učinke vezanjem na površinu ćelija hemokinskih receptora poput CCR1 i CCR3.^[4]^[5] Ljudski CCL15 gen obuhvata četiri egzona i nalazi se u orijentaciji od glave do repa na hromosomu 17 sa genom drugog CC hemokina poznatog kao CCL14.^[6]

Reference uredi

^ ^a ^b ^c ENSG00000275528 GRCh38: Ensembl release 89: ENSG00000275718, ENSG00000275528 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pardigol et al. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Proc. Natl. Acad. Sci. 95: 6308-6313, 1998.
^ Youn et al. Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J. Immun. 159: 5201-5205, 1997.
^ Coulin et al. Characterization of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines. Europ. J. Biochem. 248: 507-515, 1997.
^ Naruse et al. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics 34: 236-240, 1996.