Dodatni češljoliki protein 3 (Drosophila) jest protein koji je kod ljudi kodiran genom ASXL3.[5] Dužina polipeptidnog lanca iznosi 2.248 aminokiselina, a molekulska masa – 241.919.

ASXL3
Identifikatori
AliasiASXL3
Vanjski ID-jeviOMIM: 615115 MGI: 2685175 HomoloGene: 19371 GeneCards: ASXL3
Lokacija gena (čovjek)
Hromosom 18 (čovjek)
Hrom.Hromosom 18 (čovjek)[1]
Hromosom 18 (čovjek)
Genomska lokacija za ASXL3
Genomska lokacija za ASXL3
Bend18q12.1Početak33,578,219 bp[1]
Kraj33,751,195 bp[1]
Lokacija gena (miš)
Hromosom 18 (miš)
Hrom.Hromosom 18 (miš)[2]
Hromosom 18 (miš)
Genomska lokacija za ASXL3
Genomska lokacija za ASXL3
Bend18|18 A2Početak22,477,303 bp[2]
Kraj22,663,284 bp[2]
Ontologija gena
Molekularna funkcija vezivanje iona metala
vezivanje sa DNK
chromatin binding
peroxisome proliferator activated receptor binding
Ćelijska komponenta jedro
PR-DUB complex
Biološki proces GO:0009373 regulation of transcription, DNA-templated
transcription, DNA-templated
animal organ morphogenesis
GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_030632

NM_001167777

RefSeq (bjelančevina)

NP_085135

NP_001161249

Lokacija (UCSC)Chr 18: 33.58 – 33.75 MbChr 18: 22.48 – 22.66 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

Simboli
1020304050
MKDKRKKKDRTWAEAARLALEKHPNSPMTAKQILEVIQKEGLKETSGTSP
LACLNAMLHTNTRIGDGTFFKIPGKSGLYALKKEESSCPADGTLDLVCES
ELDGTDMAEANAHGEENGVCSKQVTDEASSTRDSSLTNTAVQSKLVSSFQ
QHTKKALKQALRQQQKRRNGVSMMVNKTVPRVVLTPLKVSDEQSDSPSGS
ESKNGEADSSDKEMKHGQKSPTGKQTSQHLKRLKKSGLGHLKWTKAEDID
IETPGSILVNTNLRALINKHTFASLPQHFQQYLLLLLPEVDRQMGSDGIL
RLSTSALNNEFFAYAAQGWKQRLAEGEFTPEMQLRIRQEIEKEKKTEPWK
EKFFERFYGEKLGMSREESVKLTTGPNNAGAQSSSSCGTSGLPVSAQTAL
AEQQPKSMKSPASPEPGFCATLCPMVEIPPKDIMAELESEDILIPEESVI
QEEIAEEVETSICECQDENHKTIPEFSEEAESLTNSHEEPQIAPPEDNLE
SCVMMNDVLETLPHIEVKIEGKSESPQEEMTVVIDQLEVCDSLIPSTSSM
THVSDTEHKESETAVETSTPKIKTGSSSLEGQFPNEGIAIDMELQSDPEE
QLSENACISETSFSSESPEGACTSLPSPGGETQSTSEESCTPASLETTFC
SEVSSTENTDKYNQRNSTDENFHASLMSEISPISTSPEISEASLMSNLPL
TSEASPVSNLPLTSETSPMSDLPLTSETSSVSSMLLTSETTFVSSLPLPS
ETSPISNSSINERMAHQQRKSPSVSEEPLSPQKDESSATAKPLGENLTSQ
QKNLSNTPEPIIMSSSSIAPEAFPSEDLHNKTLSQQTCKSHVDTEKPYPA
SIPELASTEMIKVKNHSVLQRTEKKVLPSPLELSVFSEGTDNKGNELPSA
KLQDKQYISSVDKAPFSEGSRNKTHKQGSTQSRLETSHTSKSSEPSKSPD
GIRNESRDSEISKRKTAEQHSFGICKEKRARIEDDQSTRNISSSSPPEKE
QPPREEPRVPPLKIQLSKIGPPFIIKSQPVSKPESRASTSTSVSGGRNTG
ARTLADIKARAQQARAQREAAAAAAVAAAASIVSGAMGSPGEGGKTRTLA
HIKEQTKAKLFAKHQARAHLFQTSKETRLPPPLSSKEGPPNLEVSSTPET
KMEGSTGVIIVNPNCRSPSNKSAHLRETTTVLQQSLNPSKLPETATDLSV
HSSDENIPVSHLSEKIVSSTSSENSSVPMLFNKNSVPVSVCSTAISGAIK
EHPFVSSVDKSSVLMSVDSANTTISACNISMLKTIQGTDTPCIAIIPKCI
ESTPISATTEGSSISSSMDDKQLLISSSSASNLVSTQYTSVPTPSIGNNL
PNLSTSSVLIPPMGINNRFPSEKIAIPGSEEQATVSMGTTVRAALSCSDS
VAVTDSLVAHPTVAMFTGNMLTINSYDSPPKLSAESLDKNSGPRNRADNS
GKPQQPPGGFAPAAINRSIPCKVIVDHSTTLTSSLSLTVSVESSEASLDL
QGRPVRTEASVQPVACPQVSVISRPEPVANEGIDHSSTFIAASAAKQDSK
TLPATCTSLRELPLVPDKLNEPTAPSHNFAEQARGPAPFKSEADTTCSNQ
YNPSNRICWNDDGMRSTGQPLVTHSGSSKQKEYLEQSCPKAIKTEHANYL
NVSELHPRNLVTNVALPVKSELHEADKGFRMDTEDFPGPELPPPAAEGAS
SVQQTQNMKASTSSPMEEAISLATDALKRVPGAGSSGCRLSSVEANNPLV
TQLLQGNLPLEKVLPQPRLGAKLEINRLPLPLQTTSVGKTAPERNVEIPP
SSPNPDGKGYLAGTLAPLQMRKRENHPKKRVARTVGEHTQVKCEPGKLLV
EPDVKGVPCVISSGISQLGHSQPFKQEWLNKHSMQNRIVHSPEVKQQKRL
LPSCSFQQNLFHVDKNGGFHTDAGTSHRQQFYQMPVAARGPIPTAALLQA
SSKTPVGCNAFAFNRHLEQKGLGEVSLSSAPHQLRLANMLSPNMPMKEGD
EVGGTAHTMPNKALVHPPPPPPPPPPPPLALPPPPPPPPPLPPPLPNAEV
PSDQKQPPVTMETTKRLSWPQSTGICSNIKSEPLSFEEGLSSSCELGMKQ
VSYDQNEMKEQLKAFALKSADFSSYLLSEPQKPFTQLAAQKMQVQQQQQL
CGNYPTIHFGSTSFKRAASAIEKSIGILGSGSNPATGLSGQNAQMPVQNF
ADSSNADELELKCSCRLKAMIVCKGCGAFCHDDCIGPSKLCVACLVVR

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141431 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045215 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Additional sex combs like 3 (Drosophila)".

Dopunska literatura

uredi
  • Fisher CL, Randazzo F, Humphries RK, Brock HW (mart 2006). "Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family". Gene. 369: 109–18. doi:10.1016/j.gene.2005.10.033. PMID 16412590.
  • Katoh M, Katoh M (juni 2004). "Identification and characterization of ASXL3 gene in silico". International Journal of Oncology. 24 (6): 1617–22. PMID 15138607.