ARHGAP44

ARHGAP44
Identifikatori
Aliasi	ARHGAP44
Vanjski ID-jevi	OMIM: 617716 MGI: 2144423 HomoloGene: 65284 GeneCards: ARHGAP44
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	12,991,643 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	65,053,787 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • phospholipid binding; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity;
Ćelijska komponenta	• citoplazma; • reciklirajući endosom; • citosol; • međućelijske veze; • endozom; • dendritična kičma; • projekcija ćelije; • sinapsa; • leading edge membrane; • glutamatergic synapse; • intracellular anatomical structure; • GO:0097483, GO:0097481 postsynaptic density; • presynaptic active zone;
Biološki proces	• GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • regulation of small GTPase mediated signal transduction; • GO:0072468 Transdukcija signala; • Egzocitoza; • regulation of actin cytoskeleton organization; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • regulation of dendritic spine morphogenesis; • modification of dendritic spine; • neurotransmitter receptor transport, endosome to postsynaptic membrane; • negative regulation of Rac protein signal transduction; • modification of postsynaptic structure; • regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane;
	Izvori:Amigo / QuickGO
Ortolozi
	9912
	216831
	ENSG00000006740
	ENSMUSG00000033389
	Q17R89
	Q5SSM3
	NM_014859; NM_001321164; NM_001321166; NM_001321167; NM_001321168
	NM_001099288; NM_175003
	NP_001308093; NP_001308095; NP_001308096; NP_001308097; NP_055674
NP_001092758; NP_778168; NP_001395152; NP_001395153; NP_001395155;
	NP_001395157
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Rho GTPazno aktivirajući protein 44 jest protein koji je kod ljudi kodiran genom ARHGAP44.^[5]

Dužina polipeptidnog lanca je 818 aminokiselina, sa molekulskom težinom od 89.247.^[6]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MKKQFNRMRQ	LANQTVGRAE	KTEVLSEDLL	QVEKRLELVK	QVSHSTHKKL
TACLQGQQGA	EADKRSKKLP	LTTLAQCLME	GSAILGDDTL	LGKMLKLCGE
TEDKLAQELI	HFELQVERDV	IEPLFLLAEV	EIPNIQKQRK	HLAKLVLDMD
SSRTRWQQTS	KSSGLSSSLQ	PAGAKADALR	EEMEEAANRV	EICRDQLSAD
MYSFVAKEID	YANYFQTLIE	VQAEYHRKSL	TLLQAVLPQI	KAQQEAWVEK
PSFGKPLEEH	LTISGREIAF	PIEACVTMLL	ECGMQEEGLF	RVAPSASKLK
KLKAALDCCV	VDVQEYSADP	HAIAGALKSY	LRELPEPLMT	FELYDEWIQA
SNVQEQDKKL	QALWNACEKL	PKANHNNIRY	LIKFLSKLSE	YQDVNKMTPS
NMAIVLGPNL	LWPQAEGNIT	EMMTTVSLQI	VGIIEPIIQH	ADWFFPGEIE
FNITGNYGSP	VHVNHNANYS	SMPSPDMDPA	DRRQPEQARR	PLSVATDNMM
LEFYKKDGLR	KIQSMGVRVM	DTNWVARRGS	SAGRKVSCAP	PSMQPPAPPA
ELAAPLPSPL	PEQPLDSPAA	PALSPSGLGL	QPGPERTSTT	KSKELSPGSA
QKGSPGSSQG	TACAGTQPGA	QPGAQPGASP	SPSQPPADQS	PHTLRKVSKK
LAPIPPKVPF	GQPGAMADQS	AGQPSPVSLS	PTPPSTPSPY	GLSYPQGYSL
ASGQLSPAAA	PPLASPSVFT	STLSKSRPTP	KPRQRPTLPP	PQPPTVNLSA
SSPQSTEAPM	LDGMSPGESM	STDLVHFDIP	SIHIELGSTL	RLSPLEHMRR
HSVTDKRDSE	EESESTAL

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006740 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033389 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Rho GTPase activating protein 44". Pristupljeno 13. 5. 2013.
^ "UniProt, Q17R89". Pristupljeno 12. 9. 2017.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006740 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033389 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Rho GTPase activating protein 44". Pristupljeno 13. 5. 2013.

[UniProt-6] "UniProt, Q17R89". Pristupljeno 12. 9. 2017.

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