TIE1

Pretraga za
Strukture	Swiss-model
Domene	InterPro

Tirozin-kinaza sa imunoglobulinolikim i EGF-likim domenima 1
Tirozin-kinaza sa imunoglobulinolikim i EGF-likim domenima 1
Identifikatori
Simbol	TIE1
Alt. simboli	TIE, JTK14
NCBI gen	7075
HGNC	11809
OMIM	600222
RefSeq	NM_005424
UniProt	P35590
Ostali podaci
EC broj	2.7.1.112
Lokus	Hrom. 1 p34-p33
Strukture
Pretraga za
Strukture	Swiss-model
Domene	InterPro

TIE1
Identifikatori
Aliasi	TIE1
Vanjski ID-jevi	OMIM: 600222 MGI: 99906 HomoloGene: 3957 GeneCards: TIE1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	43,323,108 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	118,347,258 bp
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • nucleotide binding; • protein kinase activity; • kinase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • transmembrane receptor protein tyrosine kinase activity; • protein tyrosine kinase activity; • ATP binding; • Receptorska tirozin-kinaza; • transmembrane signaling receptor activity;
Ćelijska komponenta	• integral component of membrane; • membrana; • ćelijska membrana; • integral component of plasma membrane; • citoplazma; • receptor complex;
Biološki proces	• plasma membrane fusion; • response to retinoic acid; • Fosforilacija; • in utero embryonic development; • Vaskulogeneza; • protein phosphorylation; • negative regulation of cell migration; • blood vessel development; • Angiogeneza; • negative regulation of angiogenesis; • mesoderm development; • GO:0072468 Transdukcija signala; • peptidyl-tyrosine phosphorylation; • negative regulation of signal transduction; • Ćelijska diferencijacija; • negative regulation of apoptotic process; • positive regulation of ERK1 and ERK2 cascade; • transmembrane receptor protein tyrosine kinase signaling pathway; • positive regulation of angiogenesis;
	Izvori:Amigo / QuickGO
Ortolozi
	7075
	21846
	ENSG00000066056
	ENSMUSG00000033191
	P35590
	Q06806
	NM_001253357; NM_005424
	NM_011587
	NP_001240286; NP_005415
	NP_035717
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Tirozin-kinaza sa imunoglobulinolikim i EGF-likim domenima 1, znana i kao TIE1 je angiopoietinsi receptor koji je kod ljudi kodiran genom TIE1 sa hromosoma 1.^[5]

Funkcija

TIE1 je protein na ćelijskoj površini koji se eksprimira isključivo u endotelnim ćelijama; međutim pokazalo se da je eksprimiran i u nezrelim hematopoetskim ćelijama^[6] i trombocitima.^[7] TIE1 pojačava regulaciju molekula ćelijske adhezije (CAM) VCAM-1, E-selektina i ICAM-1, putem p38 -ovisnih mehanizama. Vezivanje imunskih ćelija dobijenih iz monocita za endotelne ćelije je takođe poboljšano ekspresijom TIE1. TIE1 ima proupalni efekt i može imati ulogu u endotelnim upalnim bolestima kao što je ateroskleroza.^[8]

Također pogledajte

Angiopoetin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000066056 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033191 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Molecular and Cellular Biology. 12 (4): 1698–707. doi:10.1128/mcb.12.4.1698. PMC 369613. PMID 1312667.
^ Rodewald HR, Sato TN (January 1996). "Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells". Oncogene. 12 (2): 397–404. PMID 8570217.
^ Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP (2000). "Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets". Journal of Vascular Research. 37 (6): 437–42. doi:10.1159/000054075. PMID 11146396. S2CID 43509019.
^ Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP (July 2008). "Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules". Biochemical and Biophysical Research Communications. 371 (3): 475–9. doi:10.1016/j.bbrc.2008.04.091. PMID 18448073.

Vanjski linkovi

Receptor, TIE-1 na US National Library of Medicine Medical Subject Headings (MeSH)

Portal Biologija

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000066056 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033191 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1312667-5] Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Molecular and Cellular Biology. 12 (4): 1698–707. doi:10.1128/mcb.12.4.1698. PMC 369613. PMID 1312667.

[6] Rodewald HR, Sato TN (January 1996). "Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells". Oncogene. 12 (2): 397–404. PMID 8570217.

[pmid11146396-7] Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP (2000). "Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets". Journal of Vascular Research. 37 (6): 437–42. doi:10.1159/000054075. PMID 11146396. S2CID 43509019.

[pmid18448073-8] Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP (July 2008). "Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules". Biochemical and Biophysical Research Communications. 371 (3): 475–9. doi:10.1016/j.bbrc.2008.04.091. PMID 18448073.

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