Hormon rasta 1

Hormon rasta 1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1AXI, 1HUW, 1A22, 1HGU, 3HHR, 1KF9, 1HWG, 1BP3, 1HWH
Identifikatori
Aliasi	GH1
Vanjski ID-jevi	OMIM: 139250 MGI: 95707 HomoloGene: 128036 GeneCards: GH1
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	63,918,839 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	106,192,691 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• hormone activity; • vezivanje iona metala; • GO:0001948, GO:0016582 vezivanje za proteine; • growth factor activity; • growth hormone receptor binding; • prolactin receptor binding;
Ćelijska komponenta	• extracellular region; • Vanćelijsko; • endosome lumen; • growth hormone receptor complex; • collagen-containing extracellular matrix;
Biološki proces	• growth hormone receptor signaling pathway via JAK-STAT; • response to estradiol; • positive regulation of MAP kinase activity; • positive regulation of receptor internalization; • bone maturation; • growth hormone receptor signaling pathway; • positive regulation of insulin-like growth factor receptor signaling pathway; • positive regulation of multicellular organism growth; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of phosphatidylinositol 3-kinase signaling; • positive regulation of receptor signaling pathway via JAK-STAT; • positive regulation of activation of Janus kinase activity; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of signaling receptor activity; • positive regulation of glucose transmembrane transport; • response to nutrient levels; • positive regulation of growth; • animal organ development; • GO:0072468 Transdukcija signala;
	Izvori:Amigo / QuickGO
Ortolozi
	2688
	14599
	ENSG00000259384
	ENSMUSG00000020713
	P01241
	P06880
	NM_000515; NM_022559; NM_022560; NM_022561; NM_022562
	NM_008117
	NP_000506; NP_072053; NP_072054
	NP_032143
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Somatotropin 1 je protein koji kod čovjeka kodira gen GH1.^[5]^[6]^[7]^[8]

Ovaj protein je kodirani član porodice somatotropin / prolaktin hormona koji imaju važnu ulogu u kontroli rasta. Ovaj gen, zajedno s četiri druga srodna gena, nalazi se na lokusu za hormon rasta, na hromosomu 17, gdje se smjenjuju u istoj transkripcijskoj orijentaciji, aranžmani za koje se smatra da su evoluirali u niz gena duplikata.

Pet gena dijele izuzetno visok stepen identiteta sekvence. Alternative nastaju preradom iRNK, stvarajući dodatne izoforme svakog od pet hormona rasta. To dovodi do dalje različitosti i potencijala za specijalizaciju. Ovaj posebni član porodice se stvara u hipofizi, ali ne i u posteljičnom tkivu, kao što je slučaj za ostala četiri gena u lokusu hormona rasta. Mutacije u ili delecijskim genima dovode do nedostatka hormona rasta i niskog rasta.^[9]

Također pogledajte

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000259384 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020713 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Barsh G. S., Seeburg P. H., Gelinas R. E. (1983): The human growth hormone gene family: structure and evolution of the chromosomal locus. Nucleic Acids, 11 (12): 3939–3958.| pmid = 6306568 | pmc = 326017.
^ Hall J. E., Guyton A. C. (2006): Textbook of medical physiology, 11th edition. Elsevier Saunders, St. Louis, Mo, ISBN 0-7216-0240-1.
^ Voet D., Voet J. (1995): Biochemistry, 2nd Ed. Wiley, http://www.wiley.com/college/math/chem/cg/sales/voet.html.
^ Hunter G. K. (2000): Vital Forces. The discovery of the molecular basis of life. Academic Press, London 2000, ISBN 0-12-361811-8.
^ Entrez Gene: GH1 growth hormone 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2688.

Dopunska literatura

Binder G (2003). "Isolated growth hormone deficiency and the GH-1 gene: update 2002". Horm. Res. 58 Suppl 3: 2–6. doi:10.1159/000066476. PMID 12435888.
Waxman DJ, O'Connor C (2007). "Growth hormone regulation of sex-dependent liver gene expression". Mol. Endocrinol. 20 (11): 2613–29. doi:10.1210/me.2006-0007. PMID 16543404.
Cattini PA, Yang X, Jin Y, Detillieux KA (2006). "Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repression". Neuroendocrinology. 83 (3–4): 145–53. doi:10.1159/000095522. PMID 17047377.CS1 održavanje: više imena: authors list (link)
Wagner K, Hemminki K, Försti A (2007). "The GH1/IGF-1 axis polymorphisms and their impact on breast cancer development". Breast Cancer Res. Treat. 104 (3): 233–48. doi:10.1007/s10549-006-9411-9. PMID 17082888.CS1 održavanje: više imena: authors list (link)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000259384 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020713 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Barsh G. S., Seeburg P. H., Gelinas R. E. (1983): The human growth hormone gene family: structure and evolution of the chromosomal locus. Nucleic Acids, 11 (12): 3939–3958.| pmid = 6306568 | pmc = 326017.

[6] Hall J. E., Guyton A. C. (2006): Textbook of medical physiology, 11th edition. Elsevier Saunders, St. Louis, Mo, ISBN 0-7216-0240-1.

[7] Voet D., Voet J. (1995): Biochemistry, 2nd Ed. Wiley, http://www.wiley.com/college/math/chem/cg/sales/voet.html.

[8] Hunter G. K. (2000): Vital Forces. The discovery of the molecular basis of life. Academic Press, London 2000, ISBN 0-12-361811-8.

[9] Entrez Gene: GH1 growth hormone 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2688.

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