Hormon rasta 1

(Preusmjereno sa Somatotropin 1)

Somatotropin 1 je protein koji kod čovjeka kodira gen GH1.[3][4][5][6]

Hormon rasta 1
Dostupne strukture
PDBPretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova

1AXI, 1HUW, 1A22, 1HGU, 3HHR, 1KF9, 1HWG, 1BP3, 1HWH

Identifikatori
AliasiGH1
Vanjski ID-jeviOMIM: 139250 HomoloGene: 128036 GeneCards: GH1
Lokacija gena (čovjek)
Hromosom 17 (čovjek)
Hrom.Hromosom 17 (čovjek)[1]
Hromosom 17 (čovjek)
Genomska lokacija za Hormon rasta 1
Genomska lokacija za Hormon rasta 1
Bend17q23.3Početak63,917,200 bp[1]
Kraj63,918,839 bp[1]
Obrazac RNK ekspresije




Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija hormone activity
metal ion binding
GO:0001948, GO:0016582 protein binding
growth factor activity
growth hormone receptor binding
prolactin receptor binding
Ćelijska komponenta extracellular region
Vanćelijsko
endosome lumen
growth hormone receptor complex
collagen-containing extracellular matrix
Biološki proces growth hormone receptor signaling pathway via JAK-STAT
response to estradiol
positive regulation of MAP kinase activity
positive regulation of receptor internalization
bone maturation
growth hormone receptor signaling pathway
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of multicellular organism growth
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of activation of Janus kinase activity
positive regulation of tyrosine phosphorylation of STAT protein
regulation of signaling receptor activity
positive regulation of glucose transmembrane transport
response to nutrient levels
positive regulation of growth
animal organ development
GO:0072468 Transdukcija signala
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_000515
NM_022559
NM_022560
NM_022561
NM_022562

n/a

RefSeq (bjelančevina)

NP_000506
NP_072053
NP_072054

n/a

Lokacija (UCSC)Chr 17: 63.92 – 63.92 Mbn/a
PubMed pretraga[2]n/a
Wikipodaci
Pogledaj/uredi – čovjek

Ovaj protein je kodirani član porodice somatotropin / prolaktin hormona koji imaju važnu ulogu u kontroli rasta. Ovaj gen, zajedno s četiri druga srodna gena, nalazi se na lokusu za hormon rasta, na hromosomu 17, gdje se smjenjuju u istoj transkripcijskoj orijentaciji, aranžmani za koje se smatra da su evoluirali u niz gena duplikata.

Pet gena dijele izuzetno visok stepen identiteta sekvence. Alternative nastaju preradom iRNK, stvarajući dodatne izoforme svakog od pet hormona rasta. To dovodi do dalje različitosti i potencijala za specijalizaciju. Ovaj posebni član porodice se stvara u hipofizi, ali ne i u posteljičnom tkivu, kao što je slučaj za ostala četiri gena u lokusu hormona rasta. Mutacije u ili delecijskim genima dovode do nedostatka hormona rasta i niskog rasta.[7]

Također pogledajte uredi

Reference uredi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000259384 - Ensembl, maj 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Barsh G. S., Seeburg P. H., Gelinas R. E. (1983): The human growth hormone gene family: structure and evolution of the chromosomal locus. Nucleic Acids, 11 (12): 3939–3958.| pmid = 6306568 | pmc = 326017.
  4. ^ Hall J. E., Guyton A. C. (2006): Textbook of medical physiology, 11th edition. Elsevier Saunders, St. Louis, Mo, ISBN 0-7216-0240-1.
  5. ^ Voet D., Voet J. (1995): Biochemistry, 2nd Ed. Wiley, http://www.wiley.com/college/math/chem/cg/sales/voet.html.
  6. ^ Hunter G. K. (2000): Vital Forces. The discovery of the molecular basis of life. Academic Press, London 2000, ISBN 0-12-361811-8.
  7. ^ Entrez Gene: GH1 growth hormone 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2688.

Dopunska literatura uredi

  • Binder G (2003). "Isolated growth hormone deficiency and the GH-1 gene: update 2002". Horm. Res. 58 Suppl 3: 2–6. doi:10.1159/000066476. PMID 12435888.
  • Waxman DJ, O'Connor C (2007). "Growth hormone regulation of sex-dependent liver gene expression". Mol. Endocrinol. 20 (11): 2613–29. doi:10.1210/me.2006-0007. PMID 16543404.
  • Cattini PA, Yang X, Jin Y, Detillieux KA (2006). "Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repression". Neuroendocrinology. 83 (3–4): 145–53. doi:10.1159/000095522. PMID 17047377.CS1 održavanje: više imena: authors list (link)
  • Wagner K, Hemminki K, Försti A (2007). "The GH1/IGF-1 axis polymorphisms and their impact on breast cancer development". Breast Cancer Res. Treat. 104 (3): 233–48. doi:10.1007/s10549-006-9411-9. PMID 17082888.CS1 održavanje: više imena: authors list (link)