CKMT1B
Mitohondrijska kreatin-kinaza 1B, znana i kao CKMT1B je jedan od dva gena koji kodiraju sveprisutnu mitohondrijsku kreatin kinazu (sveprisutni mtCK ili CKMT1).[5]
Funkcija uredi
Mitohondrijskog kreatin-kinaza (MtCK) odgovorna je za prijenos visokoenergetskog fosfata iz mitohondrija u citosolni nosač kreatin. Pripada porodici kreatin-kinaznih izoenzima. Postoji kao dva izoenzima, sarkomerni MtCK (CKMT2) i sveprisutni MtCK, kodirana odvojenim genima. Mitohondrijska kreatin-kinaza javlja se u dva različita oligomerna oblika: dimerima i oktamerima, za razliku od isključivo dimernih izoenzima citosolne kreatin-kinaze. Sveprisutna mitohondrijska kreatin-kinaza ima 80% homologije sa kodirajućim egzonima sarkomerne mitohondrijske kreatin-kinaze. Identificirana su dva gena koja se nalaze međusobno blizu, na hromosomu 15 (CKMT1A i CKMT1B (ovaj gen)) koji kodiraju identične proteine mitohondrijske kreatin-kinaze.[5]
Klinički značaj uredi
Mnogi maligni karcinomi sa lošom prognozom pokazali su prekomjernu ekspresiju sveprisutne mitohondrijske kreatin-kinaze; ovo može biti povezano s velikim prometom energije i neuspjehom apoptoznog uklanjanja ćelija karcinoma.[5]
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000237289 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000308 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c "Entrez Gene: CKMT1B creatine kinase, mitochondrial 1B".
Vanjski linkovi uredi
- Lokacija ljudskog genoma CKMT1B i stranica sa detaljima o genu CKMT1B u UCSC Genome Browseru.
Dopunska literatura uredi
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- Eder M, Fritz-Wolf K, Kabsch W, Wallimann T, Schlattner U (2000). "Crystal structure of human ubiquitous mitochondrial creatine kinase". Proteins. 39 (3): 216–25. doi:10.1002/(SICI)1097-0134(20000515)39:3<216::AID-PROT40>3.0.CO;2-#. PMID 10737943.
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- Schlattner U, Dolder M, Wallimann T, Tokarska-Schlattner M (2002). "Mitochondrial creatine kinase and mitochondrial outer membrane porin show a direct interaction that is modulated by calcium". J. Biol. Chem. 276 (51): 48027–30. doi:10.1074/jbc.M106524200. PMID 11602586.
- Schlattner U, Wallimann T (2002). "A quantitative approach to membrane binding of human ubiquitous mitochondrial creatine kinase using surface plasmon resonance". J. Bioenerg. Biomembr. 32 (1): 123–31. doi:10.1023/A:1005576831968. PMID 11768757.
- Schlattner U, Möckli N, Speer O, Werner S, Wallimann T (2002). "Creatine kinase and creatine transporter in normal, wounded, and diseased skin". J. Invest. Dermatol. 118 (3): 416–23. doi:10.1046/j.0022-202x.2001.01697.x. PMID 11874479.