CDC42BPA

Serin/treonin-protein kinaza MRCK alfa je enzim tkojeg kod ljudi kodira gen CDC42BPA. Protein kojeg kodira ovaj gen član je porodice serin /[[treonin protein kinaza. Ova kinaza sadrži više funkcionalnih domena. Njegov kinazni domen vrlo je sličan domenu protein kinazi miotonusne distrofije (DMPK). Ova kinaza također sadrži domen interaktivnog vezanja Rac (CRIB) a pokazano je da veže CDC42. Može funkcionirati kao CDC42 nizvodni efektor, koji posreduje CDC42, induciranim perifernom aktinskom formacijom i promovirajući citoskeletnu reorganizaciju. Opisano je više alternativno spojenih varijanti transkripta, a zabilježena je i priroda cijele dužine dvije od njih.

CDC42BPA
Identifikatori
Aliasi	CDC42BPA
Vanjski ID-jevi	OMIM: 603412 MGI: 2441841 HomoloGene: 55765 GeneCards: CDC42BPA
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek) Bend 1q42.13 Početak 226,989,865 bp Kraj 227,318,492 bp
Lokacija gena (miš) Hrom. Hromosom 1 (miš) Bend 1|1 H4 Početak 179,788,037 bp Kraj 179,993,168 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • aktivnost sa transferazom • nucleotide binding • protein serine/threonine kinase activity • protein kinase activity • GO:0001948, GO:0016582 vezivanje za proteine • ATP binding • magnesium ion binding • vezivanje iona metala • vezivanje identičnih proteina • kinase activity Ćelijska komponenta • citoplazma • actomyosin • Egzosom • cell leading edge • cell-cell junction • lamellipodium • projekcija ćelije • citoskelet Biološki proces • protein phosphorylation • actomyosin structure organization • GO:0007243 intracellular signal transduction • Ćelijska migracija • Fosforilacija • actin cytoskeleton reorganization • actin cytoskeleton organization • peptidyl-threonine phosphorylation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	8476	226751
Ensembl	ENSG00000143776	ENSMUSG00000026490
UniProt	Q5VT25	Q3UU96
RefSeq (mRNK)	NM_003607 NM_014826 NM_001366010 NM_001366011 NM_001366019 NM_001387550 NM_001394014	NM_001033285 NM_001346804 NM_001346805 NM_001359541 NM_001359542 NM_001359543 NM_001359544 NM_001359545 NM_001359546 NM_001359547 NM_001359548 NM_001359549
RefSeq (bjelančevina)	NP_003598 NP_055641 NP_001352939 NP_001352940 NP_001352948	NP_001028457 NP_001333733 NP_001333734 NP_001346470 NP_001346471 NP_001346472 NP_001346473 NP_001346474 NP_001346475 NP_001346476 NP_001346477 NP_001346478
Lokacija (UCSC)	Chr 1: 226.99 – 227.32 Mb	Chr 1: 179.79 – 179.99 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Vanjski linkovi

• Lokacija ljudskog genoma CDC42BPA i stranica sa detaljima o genu CDC42BPA u UCSC Genome Browseru.

Dopunska literatura

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