Šablon:UEFA Evropska liga 2018/19 - 1/16
Prve utakmice odigrale su se 12. i 14. februara, a uzvratne 20. i 21. februara 2019.
| Tim 1 | Rez. | Tim 2 | Prva utakmica | Druga utakmica |
|---|---|---|---|---|
Viktoria Plzeň 
|
2–4 |  Dinamo Zagreb
|
2–1 | 0–3 |
Club Brugge 
|
2–5 |  Red Bull Salzburg
|
2–1 | 0–4 |
| Rapid Beč
|
0–5 |  Inter Milano
|
0–1 | 0–4 |
| Slavia Prag
|
1–1 | Genk
|
0–0 | 4–1 |
Krasnodar 
|
1–1 (a) |  Bayer Leverkusen
|
0–0 | 1–1 |
Zürich 
|
1–5 | Napoli
|
1–3 | 0–2 |
Malmö 
|
1–5 |  Chelsea
|
1–2 | 0–3 |
Šahtar Donjeck 
|
3–6 | Eintracht Frankfurt
|
2–2 | 1–4 |
Celtic 
|
0–3 |  Valencia
|
0–2 | 0–1 |
Rennes 
|
6–4 | Real Betis
|
3–3 | 3–1 |
Olympiakos 
|
2–3 | Dinamo Kijev
|
2–2 | 0–1 |
| Lazio
|
0–3 | Sevilla
|
0–1 | 0–2 |
Fenerbahçe 
|
2–3 | Zenit Sankt Peterburg
|
1–0 | 1–3 |
Sporting Lisabon 
|
1–2 | Villarreal
|
0–1 | 1–1 |
BATE Borisov 
|
1–3 | Arsenal
|
1–0 | 0–3 |
| Galatasaray
|
1–2 | Benfica
|
1–2 | 0–0 |