SSR4

SSR4
Identifikatori
Aliasi	SSR4
Vanjski ID-jevi	OMIM: 300090 MGI: 1099464 HomoloGene: 4573 GeneCards: SSR4
Lokacija gena (čovjek)
Hrom.	Hromosom X
Kraj	153,798,499 bp
Lokacija gena (miš)
Hrom.	Hromosom X (miš)
Kraj	72,834,436 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ortolozi
	6748
	20832
	ENSG00000180879
	ENSMUSG00000002014
	P51571
	Q62186
	NM_001204526; NM_001204527; NM_006280
	NM_001166480; NM_009279; NM_001358212; NM_001358213
	NP_001191455; NP_001191456; NP_006271
	NP_001159952; NP_033305; NP_001345141; NP_001345142
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Translokon-pridružena podjedinica delta je protein koji je kod ljudi kodiran genom SSR4.^[5]^[6]

Pretpostavlja se da je SSR4, znan i kao TRAPD, uključen je u lučenje proteina. Nalazi se u Xq28 regiji hromosoma X, kompaktno raspoređen, glava-uz-glavu sa genom IDH3G. Ova dva gena pokreće dvosmjerni promotor, smješten između njih i kodiraju proteine koji su uključeni u nepovezane biohemijske puteve u različitim odjeljcima ćelije. Netranskripirano intergeno područje predstavlja samo 133 bp i ugrađeno je u CpG otok. Ovaj otok funkcionira kao dvosmerni promotor za pokretanje transkripcije oba funkcijski nepovezana gena sa različitim ekspresijskim obrascima. SSR4 se sastoji od šest egzona i približno je dug 70 kb, telomerno prema genu ALD. Iako alternativna prerada egzona 5 nije otkrivena u ljudskom SSR4, varijante transkripata kojima nedostaje regija homologna ljudskom egzonu 5 otkrivene su i u Xenopus laevis i Mus musculus.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180879 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002014 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brenner V, Nyakatura G, Rosenthal A, Platzer M (Nov 1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
^ ^a ^b "Entrez Gene: SSR4 signal sequence receptor, delta (translocon-associated protein delta)".

Dopunska literatura

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Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000180879 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002014 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9286695-5] Brenner V, Nyakatura G, Rosenthal A, Platzer M (Nov 1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.

[entrez-6] "Entrez Gene: SSR4 signal sequence receptor, delta (translocon-associated protein delta)".

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