Superkompleks

U modernim biološkim istraživanjima, superkompleksi otkrivemni su nakon snažnih dokaza da se mitohondrijski enzimi respiratornog lanca okupljaju u veće supramolekulske strukture koje se nazivaju respirasomi, umjesto u tradicijski fluidnog modela diskretnih enzima dispergiranih u unutrašnjoj mitohondrijskoj membrani. Ovi superkompleksi su funkcionalno aktivni i neophodni za formiranje stabilnih respiratornih kompleksa.^[1]

SupercompleksI/III/IV : kompleks I (žuta) kompleks III (zelena) i Kompleks IV (ljubičasta). A, B i E su bočni pogledi na komplekse jer su orijentirani uspravno u membrani. Horizontalne linije na E označavaju položaj membrane. D je pogled iz međumembranskog prostora. C i F je izgled iznutra matrice.

Jedan os superkomplekss kompleks I, III i IV čini jedinicu poznatu kao respirasom. Respirasomi pronađeni suu različitim vrstama i tkivima, uključujući pacovski mozak,^[2]jetru,^[2] bubrege,^[2] skeletne mišiće,^[2]^[3] srce,^[2] goveđe srce,^[4] ljudske kožne fibroblaste,^[5] gljive,^[6] biljke,^[7]^[8] i C. elegans.^[9]

Reference

^ Vartak, Rasika; Porras, Christina Ann-Marie; Bai, Yidong (2013). "Respiratory supercomplexes: structure, function and assembly". Protein & Cell. 4 (8): 582–590. doi:10.1007/s13238-013-3032-y. ISSN 1674-800X. PMC 4708086. PMID 23828195.
^ ^a ^b ^c ^d ^e Reifschneider, Nicole H.; Goto, Sataro; Nakamoto, Hideko; Takahashi, Ryoya; Sugawa, Michiru; Dencher, Norbert A.; Krause, Frank (2006). "Defining the Mitochondrial Proteomes from Five Rat Organs in a Physiologically Significant Context Using 2D Blue-Native/SDS-PAGE". Journal of Proteome Research. 5 (5): 1117–1132. doi:10.1021/pr0504440. ISSN 1535-3893. PMID 16674101.
^ Lombardi, A.; Silvestri, E.; Cioffi, F.; Senese, R.; Lanni, A.; Goglia, F.; de Lange, P.; Moreno, M. (2009). "Defining the transcriptomic and proteomic profiles of rat ageing skeletal muscle by the use of a cDNA array, 2D- and Blue native-PAGE approach". Journal of Proteomics. 72 (4): 708–721. doi:10.1016/j.jprot.2009.02.007. ISSN 1874-3919. PMID 19268720.
^ Schäfer, Eva; Dencher, Norbert A.; Vonck, Janet; Parcej, David N. (2007). "Three-Dimensional Structure of the Respiratory Chain Supercomplex I1III2IV1from Bovine Heart Mitochondria†,‡". Biochemistry. 46 (44): 12579–12585. doi:10.1021/bi700983h. ISSN 0006-2960. PMID 17927210.
^ Rodríguez-Hernández, Ángeles; Cordero, Mario D.; Salviati, Leonardo; Artuch, Rafael; Pineda, Mercé; Briones, Paz; Gómez Izquierdo, Lourdes; Cotán, David; Navas, Plácido; Sánchez-Alcázar, José A. (2009). "Coenzyme Q deficiency triggers mitochondria degradation by mitophagy". Autophagy. 5 (1): 19–33. doi:10.4161/auto.5.1.7174. hdl:10261/40287. ISSN 1554-8627. PMID 19115482.
^ Krause, F. (2006). "OXPHOS Supercomplexes: Respiration and Life-Span Control in the Aging Model Podospora anserina". Annals of the New York Academy of Sciences. 1067 (1): 106–115. doi:10.1196/annals.1354.013. ISSN 0077-8923. PMID 16803975.
^ Eubel, Holger; Heinemeyer, Jesco; Sunderhaus, Stephanie; Braun, Hans-Peter (2004). "Respiratory chain supercomplexes in plant mitochondria". Plant Physiology and Biochemistry. 42 (12): 937–942. doi:10.1016/j.plaphy.2004.09.010. ISSN 0981-9428. PMID 15707832.
^ Sunderhaus, Stephanie; Klodmann, Jennifer; Lenz, Christof; Braun, Hans-Peter (2010). "Supramolecular structure of the OXPHOS system in highly thermogenic tissue of Arum maculatum". Plant Physiology and Biochemistry. 48 (4): 265–272. doi:10.1016/j.plaphy.2010.01.010. ISSN 0981-9428. PMID 20144873.
^ Suthammarak, Wichit; Somerlot, Benjamin H.; Opheim, Elyce; Sedensky, Margaret; Morgan, Philip G. (2013). "Novel interactions between mitochondrial superoxide dismutases and the electron transport chain". Aging Cell. 12 (6): 1132–1140. doi:10.1111/acel.12144. ISSN 1474-9718. PMC 3838459. PMID 23895727.

Vanjski linkovi

Šablon:Ćelijsko disanje Šablon:Elektronski transportni lanac

[VartakPorras2013-1] Vartak, Rasika; Porras, Christina Ann-Marie; Bai, Yidong (2013). "Respiratory supercomplexes: structure, function and assembly". Protein & Cell. 4 (8): 582–590. doi:10.1007/s13238-013-3032-y. ISSN 1674-800X. PMC 4708086. PMID 23828195.

[ReifschneiderGoto2006-2] Reifschneider, Nicole H.; Goto, Sataro; Nakamoto, Hideko; Takahashi, Ryoya; Sugawa, Michiru; Dencher, Norbert A.; Krause, Frank (2006). "Defining the Mitochondrial Proteomes from Five Rat Organs in a Physiologically Significant Context Using 2D Blue-Native/SDS-PAGE". Journal of Proteome Research. 5 (5): 1117–1132. doi:10.1021/pr0504440. ISSN 1535-3893. PMID 16674101.

[LombardiSilvestri2009-3] Lombardi, A.; Silvestri, E.; Cioffi, F.; Senese, R.; Lanni, A.; Goglia, F.; de Lange, P.; Moreno, M. (2009). "Defining the transcriptomic and proteomic profiles of rat ageing skeletal muscle by the use of a cDNA array, 2D- and Blue native-PAGE approach". Journal of Proteomics. 72 (4): 708–721. doi:10.1016/j.jprot.2009.02.007. ISSN 1874-3919. PMID 19268720.

[SchäferDencher2007-4] Schäfer, Eva; Dencher, Norbert A.; Vonck, Janet; Parcej, David N. (2007). "Three-Dimensional Structure of the Respiratory Chain Supercomplex I1III2IV1from Bovine Heart Mitochondria†,‡". Biochemistry. 46 (44): 12579–12585. doi:10.1021/bi700983h. ISSN 0006-2960. PMID 17927210.

[Rodríguez-HernándezCordero2009-5] Rodríguez-Hernández, Ángeles; Cordero, Mario D.; Salviati, Leonardo; Artuch, Rafael; Pineda, Mercé; Briones, Paz; Gómez Izquierdo, Lourdes; Cotán, David; Navas, Plácido; Sánchez-Alcázar, José A. (2009). "Coenzyme Q deficiency triggers mitochondria degradation by mitophagy". Autophagy. 5 (1): 19–33. doi:10.4161/auto.5.1.7174. hdl:10261/40287. ISSN 1554-8627. PMID 19115482.

[Krause2006-6] Krause, F. (2006). "OXPHOS Supercomplexes: Respiration and Life-Span Control in the Aging Model Podospora anserina". Annals of the New York Academy of Sciences. 1067 (1): 106–115. doi:10.1196/annals.1354.013. ISSN 0077-8923. PMID 16803975.

[EubelHeinemeyer2004-7] Eubel, Holger; Heinemeyer, Jesco; Sunderhaus, Stephanie; Braun, Hans-Peter (2004). "Respiratory chain supercomplexes in plant mitochondria". Plant Physiology and Biochemistry. 42 (12): 937–942. doi:10.1016/j.plaphy.2004.09.010. ISSN 0981-9428. PMID 15707832.

[SunderhausKlodmann2010-8] Sunderhaus, Stephanie; Klodmann, Jennifer; Lenz, Christof; Braun, Hans-Peter (2010). "Supramolecular structure of the OXPHOS system in highly thermogenic tissue of Arum maculatum". Plant Physiology and Biochemistry. 48 (4): 265–272. doi:10.1016/j.plaphy.2010.01.010. ISSN 0981-9428. PMID 20144873.

[SuthammarakSomerlot2013-9] Suthammarak, Wichit; Somerlot, Benjamin H.; Opheim, Elyce; Sedensky, Margaret; Morgan, Philip G. (2013). "Novel interactions between mitochondrial superoxide dismutases and the electron transport chain". Aging Cell. 12 (6): 1132–1140. doi:10.1111/acel.12144. ISSN 1474-9718. PMC 3838459. PMID 23895727.

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