PFDN6

PFDN6
Identifikatori
Aliasi	PFDN6
Vanjski ID-jevi	OMIM: 605660 MGI: 95908 HomoloGene: 40720 GeneCards: PFDN6
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	33,298,401 bp
Lokacija gena (miš)
Hrom.	Hromosom 17 (miš)
Kraj	34,159,317 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• unfolded protein binding; • chaperone binding;
Ćelijska komponenta	• citoplazma; • prefoldin complex;
Biološki proces	• chaperone-mediated protein complex assembly; • Savijanje proteina;
	Izvori:Amigo / QuickGO
Ortolozi
	10471
	14976
ENSG00000237335; ENSG00000204220; ENSG00000235692; ENSG00000206283; ENSG00000224782;
	n/a
	ENSMUSG00000024309
	O15212; Q5STK2
	Q03958
	NM_014260; NM_001185181; NM_001265595; NM_001265596
	NM_001185182; NM_010385
NP_001172110; NP_001252524; NP_001252525; NP_055075; NP_001172110.1;
	NP_001252524.1; NP_001252525.1; NP_055075.1
	NP_001172111; NP_034515
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Prefoldinska podjedinica 6 je protein koji je kod ljudi kodiran genom PFDN6 .^[5]^[6]^[7]

Biogeneza aktinskih i tubulinskih citoskeletnih proteina uključuje interakciju novonastalih lanaca svakog od dva proteina s oligomernim proteinom prefoldinom (PFD) i njihov naknadni prijenos u citosolni šaperonin CCT (šaperonin koji sadrži TCP-1). Elektronskom mikroskopijom pokazano je da eukariotski perfoldin, koji ima sličnu strukturu kao i njegov arhejski pandan, stupa u interakciju s rasklopljenim aktinom duž vrhova isturenih krakova. Čini se da aktin u svom stanju vezanom za PFD dobija konformaciju sličnu onoj usvojenoj kada je vezan za CCT. Trodimenzijska rekonstrukcija CCT: PFD kompleksa zasnovana na krioelektronskoj mikroskopiji otkriva da se PFD veže za svaki od CCT prstenova u jedinstvenoj konformaciji preko dvije specifične CCT podjedinice koje su smještene u 1,4 raspored. Ovo definira faziranje CCT prstenova i predlaže mehanizam primopredaje za PFD.^[8]

Reference

^ ^a ^b ^c ENSG00000204220, ENSG00000235692, ENSG00000206283, ENSG00000224782 GRCh38: Ensembl release 89: ENSG00000237335, ENSG00000204220, ENSG00000235692, ENSG00000206283, ENSG00000224782 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024309 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Herberg JA, Beck S, Trowsdale J (May 1998). "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC". J Mol Biol. 277 (4): 839–57. doi:10.1006/jmbi.1998.1637. PMID 9545376.
^ Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229. S2CID 16011829.
^ "Entrez Gene: PFDN6 prefoldin subunit 6".
^ Jaime Martín-Benito, Jasminka Boskovic, Paulino Gómez-Puertas, José L. Carrascosa, C.Torrey Simons,1 Sally A. Lewis,1 Francesca Bartolini,1 Nicholas J. Cowan,1 and José M. Valpuesta2 (2002): Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT. EMBO J. 21(23): 6377–6386. pmcid: pmc136944; pmid: 12456645 ;doi: 10.1093/emboj/cdf640

Dopunska literatura

Herberg JA, Sgouros J, Jones T, et al. (1998). "Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC". Eur. J. Immunol. 28 (2): 459–67. doi:10.1002/(SICI)1521-4141(199802)28:02<459::AID-IMMU459>3.0.CO;2-Z. PMID 9521053.</ref>*Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simons CT, Staes A, Rommelaere H, et al. (2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". J. Biol. Chem. 279 (6): 4196–203. doi:10.1074/jbc.M306053200. PMID 14634002.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ostrov DA, Barnes CL, Smith LE, et al. (2007). "Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex". Tissue Antigens. 69 (2): 181–8. doi:10.1111/j.1399-0039.2006.00730.x. PMID 17257322.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] ENSG00000204220, ENSG00000235692, ENSG00000206283, ENSG00000224782 GRCh38: Ensembl release 89: ENSG00000237335, ENSG00000204220, ENSG00000235692, ENSG00000206283, ENSG00000224782 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024309 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9545376-5] Herberg JA, Beck S, Trowsdale J (May 1998). "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC". J Mol Biol. 277 (4): 839–57. doi:10.1006/jmbi.1998.1637. PMID 9545376.

[pmid9630229-6] Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229. S2CID 16011829.

[entrez-7] "Entrez Gene: PFDN6 prefoldin subunit 6".

[8] Jaime Martín-Benito, Jasminka Boskovic, Paulino Gómez-Puertas, José L. Carrascosa, C.Torrey Simons,1 Sally A. Lewis,1 Francesca Bartolini,1 Nicholas J. Cowan,1 and José M. Valpuesta2 (2002): Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT. EMBO J. 21(23): 6377–6386. pmcid: pmc136944; pmid: 12456645 ;doi: 10.1093/emboj/cdf640

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