PELO
Homolog proteina pelota jest protein koji je kod ljudi kodiran genom PELO sa hromosoma 5.[5][6]
Funkcija
urediOvaj gen kodira protein koji sadrži konzervirani signal jedarne lokalizacije. Kodirani protein može imati ulogu u spermatogenezi, kontroli ćelijskog ciklusa i u mejotskoj ćelijskoj diobi.[6] U kvascima, kompleks Dom34-Hbs1 (s ABCE1) odgovoran je za reaktivaciju ribosoma i za oporavak onih zaglavljenih na iRNK.[7] To je paralog faktora oslobađanja eRF1.
Homolog u rodu Drosophila prvi put je otkriven 1993. Mutanti pokazuju zaustavljanje ćeliskog ciklusa u G2/M fazi mejoze i veliki nebenkern oblik u kasnim spermatocitima.[8] Homolozi ljudi, kvasaca (Dom34), glista i biljaka prijavljeni su 1995.,[9] a slijedio je jedan pronađen u Archaea.[10]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000152684 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042275 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Shamsadin R, Adham IM, von Beust G, Engel W (Nov 2000). "Molecular cloning, expression and chromosome location of the human pelota gene PELO". Cytogenetics and Cell Genetics. 90 (1–2): 75–8. doi:10.1159/000015667. PMID 11060452. S2CID 35316587.
- ^ a b "Entrez Gene: PELO pelota homolog (Drosophila)".
- ^ van den Elzen AM, Schuller A, Green R, Séraphin B (februar 2014). "Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress". The EMBO Journal. 33 (3): 265–76. doi:10.1002/embj.201386123. PMC 3989619. PMID 24424461.
- ^ Castrillon DH, Gönczy P, Alexander S, Rawson R, Eberhart CG, Viswanathan S, et al. (oktobar 1993). "Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis". Genetics. 135 (2): 489–505. PMC 1205651. PMID 8244010.
- ^ Eberhart CG, Wasserman SA (oktobar 1995). "The pelota locus encodes a protein required for meiotic cell division: an analysis of G2/M arrest in Drosophila spermatogenesis". Development. 121 (10): 3477–86. PMID 7588080.
- ^ Ragan MA, Logsdon JM, Sensen CW, Charlebois RL, Doolittle WF (novembar 1996). "An archaebacterial homolog of pelota, a meiotic cell division protein in eukaryotes". FEMS Microbiology Letters. 144 (2–3): 151–5. doi:10.1111/j.1574-6968.1996.tb08522.x. PMID 8900058.
Dopunska literatura
uredi- Cheli Y, Kanaji S, Jacquelin B, Chang M, Nugent DJ, Kunicki TJ (2007). "Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1769 (9–10): 546–58. doi:10.1016/j.bbaexp.2007.06.004. PMC 2682338. PMID 17669516.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (novembar 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (januar 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
- Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (maj 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.