Katepsin K

(Preusmjereno sa Katepsin O)

Katepsin K (EC 3.4.22.38 ili katepsin O2 je katepsinski enzim iz porodice cistein peptidaza.[5][6][7][8][9][10][11][12]

Katepsin K
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1MEM, 3KWB, 3KX1, 4X6J, 1AYW, 3KW9, 1YT7, 1AU2, 4X6H, 1Q6K, 1YK7, 1ATK, 3C9E, 1AYV, 1BGO, 4N8W, 7PCK, 4DMX, 4X6I, 1NL6, 1TU6, 3O0U, 1AU4, 3OVZ, 3KWZ, 2ATO, 3O1G, 1AU0, 1BY8, 1SNK, 2AUZ, 4DMY, 4N79, 1AYU, 1U9X, 1YK8, 1AU3, 1U9V, 2BDL, 1VSN, 1U9W, 2AUX, 2R6N, 3H7D, 1NLJ, 5J94, 4YVA, 4YV8

Identifikatori
AliasiCTSK
Vanjski ID-jeviOMIM: 601105 MGI: 107823 HomoloGene: 68053 GeneCards: CTSK
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za Katepsin K
Genomska lokacija za Katepsin K
Bend1q21.3Početak150,794,880 bp[1]
Kraj150,809,577 bp[1]
Lokacija gena (miš)
Hromosom 3 (miš)
Hrom.Hromosom 3 (miš)[2]
Hromosom 3 (miš)
Genomska lokacija za Katepsin K
Genomska lokacija za Katepsin K
Bend3 F2.1|3 40.74 cMPočetak95,406,567 bp[2]
Kraj95,416,673 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija fibronectin binding
cysteine-type peptidase activity
collagen binding
GO:0070122 peptidase activity
GO:0001948, GO:0016582 vezivanje za proteine
cysteine-type endopeptidase activity
hydrolase activity
proteoglycan binding
serine-type endopeptidase activity
Ćelijska komponenta citoplazma
extracellular region
endolysosome lumen
Lizozom
Vanćelijsko
nukleoplazma
intracellular membrane-bounded organelle
lysosomal lumen
Biološki proces intramembranous ossification
positive regulation of protein targeting to mitochondrion
extracellular matrix disassembly
bone resorption
Proteoliza
toll-like receptor signaling pathway
regulation of autophagy of mitochondrion
collagen catabolic process
proteolysis involved in cellular protein catabolic process
regulation of keratinocyte differentiation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_000396

NM_007802

RefSeq (bjelančevina)

NP_000387

NP_031828

Lokacija (UCSC)Chr 1: 150.79 – 150.81 MbChr 3: 95.41 – 95.42 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Katepsin K katalizira hemijsku reakciju u kojoj se odvija:

široka proteolitska aktivnost na malim molekulama supstrata. Glavna odrednica specifičnosti je P2, koja je prvenstveno na pozicijama leucina metionina > fenilalanina, uz odsustvo arginina

Ovaj oblik katepsina, kod sisara se prominentno ispoljava u osteoklastima.

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143387 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028111 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Inaoka, T., Bilbe, G., Ishibashi, O., Tezuka, K., Kumegawa, M. and Kokubo, T. (1995). "Molecular cloning of human cDNA for cathepsin K: Novel cysteine proteinase predominantly expressed in bone". Biochem. Biophys. Res. Commun. 206: 89–96. PMID 7818555.CS1 održavanje: više imena: authors list (link)
  6. ^ Međedović S., Maslić E., Hadžiselimović R. (2000): Biologija 2. Svjetlost, Sarajevo, ISBN 9958-10-222-6.
  7. ^ Hunter G. K. (2000): Vital Forces. The discovery of the molecular basis of life. Academic Press, London 2000, ISBN 0-12-361811-8.
  8. ^ Nelson D. L., Cox M. M. (2013): Lehninger principles of biochemistry. W. H. Freeman and Co., ISBN 978-1-4641-0962-1.
  9. ^ Alberts B. (2002)ː Molecular biology of the cell. Garland Science, New York, ISBN 0-8153-3218-1.
  10. ^ Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.
  11. ^ Voet D., Voet J. (1995): Biochemistry, 2nd Ed. Wiley, http://www.wiley.com/college/math/chem/cg/sales/voet.html.
  12. ^ Bossard, M.J., Tomaszek, T.A., Thompson, S.K., Amegadzie, B.Y., Hanning, C.R., Jones, C., Kurdyla, J.T., McNulty, D.E., Drake, F.H., Gowen, M. and Levy, M.A. (1996). "Proteolytic activity of human osteoclast cathepsin K - Expression, purification, activation, and substrate identification". J. Biol. Chem. 271: 12517–12524. PMID 8647860.CS1 održavanje: više imena: authors list (link)

Vanjski linkovi

uredi