Katepsin K

Katepsin K
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1MEM, 3KWB, 3KX1, 4X6J, 1AYW, 3KW9, 1YT7, 1AU2, 4X6H, 1Q6K, 1YK7, 1ATK, 3C9E, 1AYV, 1BGO, 4N8W, 7PCK, 4DMX, 4X6I, 1NL6, 1TU6, 3O0U, 1AU4, 3OVZ, 3KWZ, 2ATO, 3O1G, 1AU0, 1BY8, 1SNK, 2AUZ, 4DMY, 4N79, 1AYU, 1U9X, 1YK8, 1AU3, 1U9V, 2BDL, 1VSN, 1U9W, 2AUX, 2R6N, 3H7D, 1NLJ, 5J94, 4YVA, 4YV8
Identifikatori
Aliasi	CTSK
Vanjski ID-jevi	OMIM: 601105 MGI: 107823 HomoloGene: 68053 GeneCards: CTSK
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	150,809,577 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	95,416,673 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• fibronectin binding; • cysteine-type peptidase activity; • collagen binding; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • cysteine-type endopeptidase activity; • hydrolase activity; • proteoglycan binding; • serine-type endopeptidase activity;
Ćelijska komponenta	• citoplazma; • extracellular region; • endolysosome lumen; • Lizozom; • Vanćelijsko; • nukleoplazma; • intracellular membrane-bounded organelle; • lysosomal lumen;
Biološki proces	• intramembranous ossification; • positive regulation of protein targeting to mitochondrion; • extracellular matrix disassembly; • bone resorption; • Proteoliza; • toll-like receptor signaling pathway; • regulation of autophagy of mitochondrion; • collagen catabolic process; • proteolysis involved in cellular protein catabolic process; • regulation of keratinocyte differentiation;
	Izvori:Amigo / QuickGO
Ortolozi
	1513
	13038
	ENSG00000143387
	ENSMUSG00000028111
	P43235
	P55097
	NM_000396
	NM_007802
	NP_000387
	NP_031828
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Katepsin K (EC 3.4.22.38 ili katepsin O2 je katepsinski enzim iz porodice cistein peptidaza.^[5]^[6]^[7]^[8]^[9]^[10]^[11]^[12]

Katepsin K katalizira hemijsku reakciju u kojoj se odvija:

široka proteolitska aktivnost na malim molekulama supstrata. Glavna odrednica specifičnosti je P2, koja je prvenstveno na pozicijama leucina metionina > fenilalanina, uz odsustvo arginina

Ovaj oblik katepsina, kod sisara se prominentno ispoljava u osteoklastima.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143387 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028111 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Inaoka, T., Bilbe, G., Ishibashi, O., Tezuka, K., Kumegawa, M. and Kokubo, T. (1995). "Molecular cloning of human cDNA for cathepsin K: Novel cysteine proteinase predominantly expressed in bone". Biochem. Biophys. Res. Commun. 206: 89–96. PMID 7818555.CS1 održavanje: više imena: authors list (link)
^ Međedović S., Maslić E., Hadžiselimović R. (2000): Biologija 2. Svjetlost, Sarajevo, ISBN 9958-10-222-6.
^ Hunter G. K. (2000): Vital Forces. The discovery of the molecular basis of life. Academic Press, London 2000, ISBN 0-12-361811-8.
^ Nelson D. L., Cox M. M. (2013): Lehninger principles of biochemistry. W. H. Freeman and Co., ISBN 978-1-4641-0962-1.
^ Alberts B. (2002)ː Molecular biology of the cell. Garland Science, New York, ISBN 0-8153-3218-1.
^ Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.
^ Voet D., Voet J. (1995): Biochemistry, 2nd Ed. Wiley, http://www.wiley.com/college/math/chem/cg/sales/voet.html.
^ Bossard, M.J., Tomaszek, T.A., Thompson, S.K., Amegadzie, B.Y., Hanning, C.R., Jones, C., Kurdyla, J.T., McNulty, D.E., Drake, F.H., Gowen, M. and Levy, M.A. (1996). "Proteolytic activity of human osteoclast cathepsin K - Expression, purification, activation, and substrate identification". J. Biol. Chem. 271: 12517–12524. PMID 8647860.CS1 održavanje: više imena: authors list (link)

Vanjski linkovi

Cathepsin K na US National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143387 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028111 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Inaoka, T., Bilbe, G., Ishibashi, O., Tezuka, K., Kumegawa, M. and Kokubo, T. (1995). "Molecular cloning of human cDNA for cathepsin K: Novel cysteine proteinase predominantly expressed in bone". Biochem. Biophys. Res. Commun. 206: 89–96. PMID 7818555.CS1 održavanje: više imena: authors list (link)

[6] Međedović S., Maslić E., Hadžiselimović R. (2000): Biologija 2. Svjetlost, Sarajevo, ISBN 9958-10-222-6.

[7] Hunter G. K. (2000): Vital Forces. The discovery of the molecular basis of life. Academic Press, London 2000, ISBN 0-12-361811-8.

[8] Nelson D. L., Cox M. M. (2013): Lehninger principles of biochemistry. W. H. Freeman and Co., ISBN 978-1-4641-0962-1.

[9] Alberts B. (2002)ː Molecular biology of the cell. Garland Science, New York, ISBN 0-8153-3218-1.

[10] Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.

[11] Voet D., Voet J. (1995): Biochemistry, 2nd Ed. Wiley, http://www.wiley.com/college/math/chem/cg/sales/voet.html.

[12] Bossard, M.J., Tomaszek, T.A., Thompson, S.K., Amegadzie, B.Y., Hanning, C.R., Jones, C., Kurdyla, J.T., McNulty, D.E., Drake, F.H., Gowen, M. and Levy, M.A. (1996). "Proteolytic activity of human osteoclast cathepsin K - Expression, purification, activation, and substrate identification". J. Biol. Chem. 271: 12517–12524. PMID 8647860.CS1 održavanje: više imena: authors list (link)

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